"MAP Kinase Signaling System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
| Descriptor ID |
D020935
|
| MeSH Number(s) |
G02.111.820.560 G03.493.560 G04.835.560
|
| Concept/Terms |
ERK1-2 Pathway- ERK1-2 Pathway
- ERK1 2 Pathway
- ERK1-2 Pathways
- Pathway, ERK1-2
- Pathways, ERK1-2
- ERK1 and ERK2 Pathway
p38 Kinase Pathway- p38 Kinase Pathway
- Kinase Pathway, p38
- Kinase Pathways, p38
- Pathway, p38 Kinase
- Pathways, p38 Kinase
- p38 Kinase Pathways
- p38 Kinase Signaling Pathway
MAP Kinase Cascade- MAP Kinase Cascade
- Cascade, MAP Kinase
- Kinase Cascade, MAP
- MAP Kinase Cascades
- MAP Kinase Modules
- MAP Kinase Module
- Module, MAP Kinase
- MAP Kinase Signaling Cascades
MEK-ERK Pathway- MEK-ERK Pathway
- MEK ERK Pathway
- MEK-ERK Pathways
- Pathway, MEK-ERK
- Pathways, MEK-ERK
JNK Pathway- JNK Pathway
- JNK Pathways
- Pathway, JNK
- Pathways, JNK
- JNK Signaling Pathway
- JNK Signaling Pathways
- Pathway, JNK Signaling
- Pathways, JNK Signaling
- Signaling Pathway, JNK
- Signaling Pathways, JNK
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Signaling System".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Signaling System".
This graph shows the total number of publications written about "MAP Kinase Signaling System" by people in this website by year, and whether "MAP Kinase Signaling System" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "MAP Kinase Signaling System" by people in Profiles.
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Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy. Nat Commun. 2022 02 04; 13(1):701.
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High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma. Br J Dermatol. 2021 12; 185(6):1186-1199.
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Increased Release of Proinflammatory Proteins in Primary Human Adipocytes and Activation of the Inflammatory NF?B, p38, and ERK Pathways upon Omentin Treatment. Obes Facts. 2020; 13(2):221-236.
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Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Small. 2019 11; 15(45):e1902699.
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Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide. Sci Rep. 2019 07 30; 9(1):11021.
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ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans. Genetics. 2019 09; 213(1):173-194.
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MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. Nucleic Acids Res. 2018 07 06; 46(12):6129-6139.
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Interplay between Obesity-Induced Inflammation and cGMP Signaling in White Adipose Tissue. Cell Rep. 2017 01 03; 18(1):225-236.
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MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation. J Immunol. 2016 11 01; 197(9):3662-3668.
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Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. Am J Hum Genet. 2016 08 04; 99(2):392-406.
MeSH information
