Next Generation Sequencing Competence Network

Next Generation Sequencing Competence Network

e.g. CCGA
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Arndt Borkhardt

Prof.
Heinrich-Heine-University Duesseldorf
Paediatric Oncology, Haematology and Clinicial Immunology
Moorenstraße 5, 40225 Düsseldorf, Germany
Düsseldorf 40225
+49 170 2268592
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Oikonomou A, Valsecchi L, Quadri M, Watrin T, Scharov K, Procopio S, Tu JW, Vogt M, Savino AM, Silvestri D, Valsecchi MG, Biondi A, Borkhardt A, Bhatia S, Cazzaniga G, Fazio G, Bardini M, Palmi C. High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia. Biochem Pharmacol. 2023 Sep 17; 217:115809. PMID: 37717691.
      Citations: 1     Fields:    Translation:Humans
    2. Spory L, Zimmermann J, Vossen-Gajcy M, Beder T, Bastian L, Alsadeq A, Winterberg D, Vogiatzi F, Wirbelauer T, Bhat H, Borkhardt A, Bhatia S, Schrappe M, Cario G, Schewe DM, Lenk L. AP-1 Transcription Factor Complex Members FOSB and FOS are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL. Hemasphere. 2023 Sep; 7(9):e945. PMID: 37670804; PMCID: PMC10476750.
      Citations:    
    3. Stachura P, Liu W, Xu HC, Wlodarczyk A, Stencel O, Pandey P, Vogt M, Bhatia S, Picard D, Remke M, Lang KS, H?ussinger D, Homey B, Lang PA, Borkhardt A, Pandyra AA. Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors. Mol Cancer. 2023 08 15; 22(1):136. PMID: 37582744; PMCID: PMC10426104.
      Citations:    Fields:    Translation:AnimalsCells
    4. Brandes D, Yasin L, Nebral K, Ebler J, Schinnerl D, Picard D, Bergmann AK, Alam J, K?hrer S, Haas OA, Attarbaschi A, Marschall T, Stanulla M, Borkhardt A, Brozou T, Fischer U, Wagener R. Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood ETV6::RUNX1+ and High Hyperdiploid Acute Lymphoblastic Leukemia. Hemasphere. 2023 Aug; 7(8):e925. PMID: 37469802; PMCID: PMC10353714.
      Citations: 2     
    5. Pandyra AA, Borkhardt A. Worms on stage. Haematologica. 2023 Jul 13. PMID: 37439330.
      Citations:    Fields:    
    6. Wurnig S, Vogt M, Hogenkamp J, Dienstbier N, Borkhardt A, Bhatia S, Hansen FK. Development of the first geldanamycin-based HSP90 degraders. Front Chem. 2023; 11:1219883. PMID: 37448856; PMCID: PMC10336212.
      Citations:    
    7. Palmi C, Bresolin S, Junk S, Fazio G, Silvestri D, Zaliova M, Oikonomou A, Scharov K, Stanulla M, Moericke A, Zimmermann M, Schrappe M, Buldini B, Bhatia S, Borkhardt A, Saitta C, Galbiati M, Bardini M, Lo Nigro L, Conter V, Valsecchi MG, Biondi A, Te Kronnie G, Cario G, Cazzaniga G. Definition and Prognostic Value of Ph-like and IKZF1plus Status in Children With Down Syndrome and B-cell Precursor Acute Lymphoblastic Leukemia. Hemasphere. 2023 Jun; 7(6):e892. PMID: 37304931; PMCID: PMC10256328.
      Citations:    
    8. Wellbrock M, Spix C, Ronckers CM, Grabow D, Filbert AL, Borkhardt A, Wollschl?ger D, Erdmann F. Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register-study based on data from the German Childhood Cancer Registry. Int J Cancer. 2023 08 15; 153(4):742-755. PMID: 37158619.
      Citations: 1     Fields:    Translation:Humans
    9. Wagener R, Brozou T, Erlacher M, Borkhardt A, Friedrich UA, Bienias M, Zinke C, Prazenicova M, Lohse J, Jahn A, Menzel M, Langanke J, Walter C, Varghese J, Dugas M, Schr?ck E, Suttorp M, Hauer J, Auer F. A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children. Genet Med. 2023 08; 25(8):100875. PMID: 37149759.
      Citations: 1     Fields:    Translation:Humans
    10. Tramsen L, Bochennek K, Sparber-Sauer M, Salzmann-Manrique E, Scheer M, Dantonello T, Borkhardt A, Dirksen U, Thorwarth A, Greiner J, Ebinger M, Weclawek-Tompol J, Ladenstein R, Ljungman G, Hallmen E, Lehrnbecher T, Koscielniak E, Klingebiel T. Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials. Cancers (Basel). 2023 Mar 30; 15(7). PMID: 37046711; PMCID: PMC10093505.
      Citations: 2     
    11. Stachura P, Stencel O, Lu Z, Borkhardt A, Pandyra AA. Arenaviruses: Old viruses present new solutions for cancer therapy. Front Immunol. 2023; 14:1110522. PMID: 37033933; PMCID: PMC10079900.
      Citations: 1     Fields:    Translation:Cells
    12. Borkhardt A, Henze G. B-cell precursor leukemias with MYC-rearrangement come into the limelight. Haematologica. 2023 03 01; 108(3):659-660. PMID: 35484663; PMCID: PMC9973467.
      Citations:    Fields:    Translation:Humans
    13. Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A, Escherich G, Gibson B, Liu HC, Loh M, Moorman AV, M?ricke A, Pieters R, Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S, Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, Geerlinks AV, Gilad G, Grainger J, Haouy S, Heaney N, Huang M, Ingham D, Krenova Z, Kuhlen M, Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S, Rohrlich P, Sinno MG, Szczepanski T, Tamesberger M, Warrier R, Wolfl M, Nirel R, Izraeli S, Borkhardt A, Schmiegelow K. EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy. Blood. 2023 02 16; 141(7):743-755. PMID: 36332176.
      Citations: 1     Fields:    Translation:HumansCells
    14. Wagener R, Elitzur S, Brozou T, Borkhardt A. Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia. Eur J Med Genet. 2023 Apr; 66(4):104725. PMID: 36764385.
      Citations: 3     Fields:    Translation:Humans
    15. Brozou T, Yasin L, Brandes D, Picard D, Walter C, Varghese J, Dugas M, Fischer U, Borkhardt A, Haas OA. Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies. Front Pediatr. 2022; 10:1080347. PMID: 36824296; PMCID: PMC9941195.
      Citations:    
    16. R?chel N, Oldenburg M, Janssen S, Pandyra AA, Liu W, Vasileiou E, Hein D, Jepsen VH, Fischer U, Picard D, K?gler G, Hauer J, Auer F, Beer A, Adams O, MacKenzie C, Jaeger M, Netea MG, Borkhardt A, G?ssling KL. Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens. Hemasphere. 2023 Feb; 7(2):e835. PMID: 36741356; PMCID: PMC9891444.
      Citations: 1     
    17. Borkhardt A, Wagener R, Brozou T. Reply to: Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients". Int J Cancer. 2023 05 01; 152(9):2013. PMID: 36647327.
      Citations:    Fields:    Translation:HumansCells
    18. Junk SV, Schaeffeler E, Zimmermann M, M?ricke A, Beier R, Sch?tte P, Fedders B, Alten J, Hinze L, Klein N, Kulozik A, Muckenthaler MU, Koehler R, Borkhardt A, Vijayakrishnan J, Ellinghaus D, Forster M, Franke A, Wintering A, Kratz CP, Schrappe M, Schwab M, Houlston RS, Cario G, Stanulla M. Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group. J Exp Clin Cancer Res. 2023 Jan 13; 42(1):21. PMID: 36639636.
      Citations:    Fields:    
    19. Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Bl?mel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, W?lfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, St?hler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S. Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation. J Immunother Cancer. 2023 01; 11(1). PMID: 36639156; PMCID: PMC9843227.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. Wagener R, Walter C, Auer F, Alzoubi D, Hauer J, Fischer U, Varghese J, Dugas M, Borkhardt A, Brozou T. The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients. Int J Cancer. 2023 04 01; 152(7):1388-1398. PMID: 36468172.
      Citations: 1     Fields:    Translation:HumansCells
    21. Sinatra L, Yang J, Schliehe-Diecks J, Dienstbier N, Vogt M, Gebing P, Bachmann LM, S?nnichsen M, Lenz T, St?hler K, Sch?ler A, Borkhardt A, Bhatia S, Hansen FK. Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity. J Med Chem. 2022 Dec 06. PMID: 36473103.
      Citations: 12     Fields:    
    22. Re?ing N, Schliehe-Diecks J, Watson PR, S?nnichsen M, Cragin AD, Sch?ler A, Yang J, Sch?ker-H?bner L, Borkhardt A, Christianson DW, Bhatia S, Hansen FK. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J Med Chem. 2022 Nov 24; 65(22):15457-15472. PMID: 36351184; PMCID: PMC9691607.
      Citations: 4     Fields:    Translation:HumansCells
    23. Borkhardt A, Sch?z J, Tr?benbach C, Wellbrock M, Spix C, Erdmann F. Temporal changes of the incidence of childhood B-cell precursor acute lymphoblastic leukaemia in Germany during the COVID-19 pandemic. Leukemia. 2022 12; 36(12):2908-2911. PMID: 36289349; PMCID: PMC9607786.
      Citations:    Fields:    Translation:HumansPHPublic Health
    24. Haas OA, Borkhardt A. Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children. Leukemia. 2022 12; 36(12):2769-2783. PMID: 36266323; PMCID: PMC9712104.
      Citations: 8     Fields:    Translation:Humans
    25. Bielack SS, Blattmann C, Borkhardt A, Cs?ka M, Hassenpflug W, Kab?ckov? E, Kager L, Kessler T, Kratz C, K?hne T, Kevric M, Lehrnbecher T, Mayer-Steinacker R, Mettmann V, Metzler M, Reichardt P, Rossig C, Sorg B, von Luettichau I, Windhager R, Hecker-Nolting S. Osteosarcoma and causes of death: A report of 1520 deceased patients from the Cooperative Osteosarcoma Study Group (COSS). Eur J Cancer. 2022 Nov; 176:50-57. PMID: 36191386.
      Citations: 5     Fields:    Translation:Humans
    26. Mezger K, Ebert S, Muhle HE, Stadt UZ, Borkhardt A, Dilloo D, Faber J, Feuchtinger T, Imschweiler T, Jorch N, Pekrun A, Schmid I, Schramm F, Zimmermann M, Horstmann MA, Escherich G. Amsacrine combined with etoposide and methylprednisolone is a feasible and safe component in first-line intensified treatment of pediatric patients with high-risk acute lymphoblastic leukemia in CoALL08-09 trial. Pediatr Blood Cancer. 2022 12; 69(12):e29997. PMID: 36129234.
      Citations: 2     Fields:    Translation:Humans
    27. Bl?mel L, Qin N, Berlandi J, Paisana E, Casc?o R, Cust?dia C, Pauck D, Picard D, Langini M, St?hler K, Meyer FD, G?bbels S, Malzkorn B, Liebau MC, Barata JT, Jeibmann A, Kerl K, Erkek S, Kool M, Pfister SM, Johann PD, Fr?hwald MC, Borkhardt A, Reifenberger G, Faria CC, Fischer U, Hasselblatt M, Bartl J, Remke M. Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors. Cell Death Dis. 2022 Sep 20; 13(9):806. PMID: 36127323; PMCID: PMC9489777.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    28. Gravemeyer J, Bechmann N, Conrad C, Eisenhofer G, Qin N, Paisana E, Langini M, Picard D, Malzkorn B, Cust?dia C, Casc?o R, Meyer FD, Bl?mel L, G?bbels S, Taban K, Bartl J, Becker JC, Stefanski A, Puget S, Barata JT, St?hler K, Fischer U, Felsberg J, Ayrault O, Reifenberger G, Borkhardt A, Faria CC, Remke M. Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis. Neuro Oncol. 2022 09 01; 24(9):1509-1523. PMID: 35307743; PMCID: PMC9435486.
      Citations: 8     Fields:    Translation:Humans
    29. Loizou L, Demetriou A, Erdmann F, Borkhardt A, Brozou T, Sharp L, McNally R. Patterns and temporal trends in the incidence of childhood and adolescence cancer in Cyprus 1998-2017: A population-based study from the Cyprus Paediatric Oncology Registry. Cancer Epidemiol. 2022 10; 80:102239. PMID: 35994888.
      Citations: 1     Fields:    Translation:Humans
    30. Fazio G, Bresolin S, Silvestri D, Quadri M, Saitta C, Vendramini E, Buldini B, Palmi C, Bardini M, Grioni A, Rigamonti S, Galbiati M, Mecca S, Savino AM, Peloso A, Tu JW, Bhatia S, Borkhardt A, Micalizzi C, Lo Nigro L, Locatelli F, Conter V, Rizzari C, Valsecchi MG, Te Kronnie G, Biondi A, Cazzaniga G. PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. EBioMedicine. 2022 Sep; 83:104224. PMID: 35985167; PMCID: PMC9403348.
      Citations: 8     Fields:    Translation:Humans
    31. Escudero A, Takagi M, Friedrich UA, Miyamoto S, Ogawa A, Imai K, Pascual B, Stepensky P, Yasin L, Elitzur S, Borkhardt A, Auer F, Vela M, P?rez-Mart?nez A, Hauer J. Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants. Leukemia. 2022 09; 36(9):2338-2342. PMID: 35902733.
      Citations: 3     Fields:    Translation:HumansCells
    32. Wellbrock M, Zeeb H, Spix C, Grabow D, Borkhardt A, Erdmann F. Survival in Children Below the Age of 15 Years With Leukemia: Temporal Patterns in Eastern and Western Germany Since German Reunification. Hemasphere. 2022 Aug; 6(8):e755. PMID: 35935611; PMCID: PMC9351893.
      Citations:    
    33. Zanini M, Bernardi F, Forget A, Talbot J, Cancila G, Gao Q, Yu H, Souphron J, Rotblat B, Diederichs S, Ramaswamy V, Suzuki H, Oro A, Buell A, Lichter P, Northcott PA, Taylor MD, Ayrault O, Bartl J, Bl?mel L, Picard D, Qin N, Nath S, Koumba IM, Wolter M, Kuonen F, Langini M, Beez T, Munoz C, Pauck D, Marquardt V, Korsch M, M?lders C, Berger D, G?bbels S, Meyer FD, Scheffler B, St?hler K, Stefanski A, Fischer U, Leprivier G, Willbold D, Steger G, Kool M, Pfister SM, Borkhardt A, Reifenberger G, Remke M. The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nat Commun. 2022 07 13; 13(1):4061. PMID: 35831316; PMCID: PMC9279496.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    34. Rohde M, Dave S, Tzankov A, Dugas M, Haferlach T, Kern W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Siebert R, Strahm B, Woessmann W, Zimmermann M, Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Borkhardt A, Burmeister T, Sandmann S, Fend F, Finger J, Mueller S, G?kbuget N, Hartmann W, Rosenwald A, von Stackelberg A, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 07 06; 13(1):3881. PMID: 35794096; PMCID: PMC9259584.
      Citations: 10     Fields:    Translation:Humans
    35. Lorenz MR, Schwarz K, Escherich C, B?tticher B, Harmsen S, H?mberg M, Schaper J, Borkhardt A, Oommen PT. The Growing Spectrum of DADA2 Manifestations-Diagnostic and Therapeutic Challenges Revisited. Front Pediatr. 2022; 10:885893. PMID: 35774100; PMCID: PMC9237362.
      Citations: 2     
    36. Erdmann F, Spix C, Schrappe M, Borkhardt A, Sch?z J. Temporal changes of the incidence of childhood cancer in Germany during the COVID-19 pandemic: Updated analyses from the German Childhood Cancer Registry. Lancet Reg Health Eur. 2022 Jun; 17:100398. PMID: 35573974; PMCID: PMC9091810.
      Citations: 5     
    37. Yoshimi A, Grinstein L, Escherich G, Naami N, Borkhardt A. Thirteen-month-old girl with hyporegenerative macrocytic anemia due to Brown-Vialetto-Van Laere syndrome 2. Am J Hematol. 2022 Nov; 97(11):1495-1496. PMID: 35441393.
      Citations:    Fields:    Translation:Humans
    38. Schedel A, Friedrich UA, Morcos MNF, Wagener R, Mehtonen J, Watrin T, Saitta C, Brozou T, Michler P, Walter C, Baksi A, Menzel M, Horak P, Paramasivam N, Fazio G, Autry RJ, Suttorp M, Bhatia S, Wadt K, Schmiegelow K, Dugas M, Richter D, Glimm H, Jessberger R, Cazzaniga G, Borkhardt A, Hauer J, Auer F, F?rsti A, Fr?hling S, Gertzen C, Gohlke H, Hein?niemi M. Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma. Int J Mol Sci. 2022 May 05; 23(9). PMID: 35563565; PMCID: PMC9106003.
      Citations: 2     Fields:    Translation:HumansCells
    39. Wagener R, Brandes D, Soura S, Alzoubi D, Yasin L, Fischer U, Borkhardt A, Brozou T, Walter C, Surowy HM, Dugas M. Noncancer-related Secondary Findings in a Cohort of 231 Children With Cancer and Their Parents. J Pediatr Hematol Oncol. 2023 03 01; 45(2):e244-e248. PMID: 35537032.
      Citations: 1     Fields:    Translation:Humans
    40. Escherich G, Zur Stadt U, Borkhardt A, Dilloo D, Feuchtinger T, Imschweiler T, Jorch N, Pekrun A, Schmid I, Schramm F, Spohn M, Zimmermann M, Horstmann MA, Faber J. Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group. Haematologica. 2022 05 01; 107(5):1026-1033. PMID: 34348455; PMCID: PMC9052901.
      Citations: 1     Fields:    Translation:Humans
    41. Hauer J, Hansen FK, Bhatia S, Spanier L, Bickel D, Dienstbier N, Woloschin V, Vogt M, Pols H, Lungerich B, Reiners J, Aghaallaei N, Diedrich D, Frieg B, Schliehe-Diecks J, Bopp B, Lang F, Gopalswamy M, Loschwitz J, Bajohgli B, Skokowa J, Borkhardt A, Smits SHJ, Jose J, Gohlke H, Kurz T. Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization. ACS Cent Sci. 2022 May 25; 8(5):636-655. PMID: 35647282; PMCID: PMC9136973.
      Citations: 7     
    42. Pastorczak A, Attarbaschi A, Bomken S, van der Werff Ten Bosch J, Elitzur S, Gennery AR, Hlavackova E, Mlynarski W, Szczepanski T, Wassenberg T, Borkhardt A, Kerekes A, Krenov? Z, Loeffen J. Consensus Recommendations for the Clinical Management of Hematological Malignancies in Patients with DNA Double Stranded Break Disorders. Cancers (Basel). 2022 Apr 14; 14(8). PMID: 35454905; PMCID: PMC9029535.
      Citations: 2     
    43. Bouaoun L, Erdmann F, Sch?z J, Borkhardt A. The impact of the COVID-19 pandemic on the future incidence of acute lymphoblastic leukaemia in children: Projections for Germany under a COVID-19 related scenario. Int J Cancer. 2022 07 01; 151(1):153-155. PMID: 35253908; PMCID: PMC9087532.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    44. R?chel N, Jepsen VH, Hein D, Fischer U, Borkhardt A, G?ssling KL. In Utero Development and Immunosurveillance of B Cell Acute Lymphoblastic Leukemia. Curr Treat Options Oncol. 2022 04; 23(4):543-561. PMID: 35294722; PMCID: PMC8924576.
      Citations: 3     Fields:    Translation:Humans
    45. von Bredow L, Tretbar M, Stopper D, Kraft FB, Hansen FK, Sch?fer TM, Hogenkamp J, Schliehe-Diecks J, Sch?ler A, Borkhardt A, Bhatia S, Held J. Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin-HDAC Inhibitor Hybrids as Multitarget Drugs. Pharmaceuticals (Basel). 2022 Mar 09; 15(3). PMID: 35337131; PMCID: PMC8952208.
      Citations: 2     
    46. Xu HC, Huang J, Pandyra AA, Pandey P, Wang R, Zhang Z, Zhuang Y, Gertzen CGW, M?nk C, Herebian D, Borkhardt A, Recher M, Gohlke H, Esposito I, Oberbarnscheidt M, H?ussinger D, Lang KS, Lang PA. Single MHC-I Expression Promotes Virus-Induced Liver Immunopathology. Hepatol Commun. 2022 07; 6(7):1620-1633. PMID: 35166071; PMCID: PMC9234681.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    47. Geron I, Savino AM, Fishman H, Tal N, Brown J, Turati VA, James C, Sarno J, Hameiri-Grossman M, Lee YN, Rein A, Maniriho H, Birger Y, Zemlyansky A, Muler I, Davis KL, Marcu-Malina V, Mattson N, Parnas O, Jamieson CHM, Chen CW, Kirsch IR, Nagler A, Enver T, Izraeli S, Wagener R, Fischer U, Barata JT, M?schen M, Borkhardt A. An instructive role for Interleukin-7 receptor a in the development of human B-cell precursor leukemia. Nat Commun. 2022 02 03; 13(1):659. PMID: 35115489; PMCID: PMC8814001.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    48. Schmitz AK, Munoz-Bendix C, Remke M, Brozou T, Borkhardt A, H?nggi D, Beez T. Second-look surgery after pediatric brain tumor resection - Single center analysis of morbidity and volumetric efficacy. Brain Spine. 2022; 2:100865. PMID: 36248154; PMCID: PMC9560669.
      Citations: 1     
    49. Haas OA, Borkhardt A. Chromosomal risk classification in high hyperdiploid acute lymphocytic leukaemia: the beginning of a new chapter. Lancet Haematol. 2022 01; 9(1):e9. PMID: 34971585.
      Citations: 1     Fields:    Translation:Humans
    50. Lang KS, Roesch A, Lang PA, Liu W, Stachura P, Xu HC, V?raljai R, Shinde P, Ganesh NU, Mack M, Van Lierop A, Huang A, Sundaram B, Picard D, Fischer U, Remke M, Homey B, H?ussinger D, Borkhardt A, Pandyra AA. BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment. Cancer Res. 2022 01 15; 82(2):264-277. PMID: 34810198; PMCID: PMC9397630.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    51. McHardy AC, L?hnemann D, K?ster J, Fischer U, Borkhardt A, Sch?nhuth A. Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo. Nat Commun. 2021 11 18; 12(1):6744. PMID: 34795237; PMCID: PMC8602313.
      Citations: 6     Fields:    Translation:Humans
    52. Michler P, Schedel A, Witschas M, Friedrich UA, Wagener R, Mehtonen J, Brozou T, Menzel M, Walter C, Pearce G, Erlacher M, Dugas M, Borkhardt A, Hauer J, Auer F, Nabi D, G?hring G, Hein?niemi M, St?lzel F. Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood. Int J Mol Sci. 2021 Oct 26; 22(21). PMID: 34769003; PMCID: PMC8583981.
      Citations: 5     Fields:    Translation:HumansCells
    53. Debisarun PA, Bulut O, Kilic G, Zoodsma M, Liu Z, Oldenburg M, Zhang B, Xu CJ, Struycken P, Koeken VACM, Moorlag SJCFM, Taks E, Ostermann PN, Schaal H, Adams O, Borkhardt A, Ten Oever J, van Crevel R, Li Y, Netea MG, G?ssling KL, R?chel N, Dom?nguez-Andr?s J, M?ller L. Induction of trained immunity by influenza vaccination - impact on COVID-19. PLoS Pathog. 2021 10; 17(10):e1009928. PMID: 34695164; PMCID: PMC8568262.
      Citations: 53     Fields:    Translation:HumansCells
    54. Hauer J, Fischer U, Borkhardt A. Toward prevention of childhood ALL by early-life immune training. Blood. 2021 10 21; 138(16):1412-1428. PMID: 34010407; PMCID: PMC8532195.
      Citations: 17     Fields:    Translation:HumansAnimals
    55. Oldenburg M, R?chel N, Janssen S, Borkhardt A, G?ssling KL. The Microbiome in Childhood Acute Lymphoblastic Leukemia. Cancers (Basel). 2021 Sep 30; 13(19). PMID: 34638430; PMCID: PMC8507905.
      Citations: 12     
    56. Sch?ker-H?bner L, Warstat R, Ahlert H, Mishra P, Kraft FB, Schliehe-Diecks J, Sch?ler A, Borkhardt A, Breit B, Bhatia S, H?gle M, G?nther S, Hansen FK. 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J Med Chem. 2021 10 14; 64(19):14620-14646. PMID: 34582215.
      Citations: 9     Fields:    Translation:HumansCells
    57. Ahmadov U, Picard D, Bartl J, Silginer M, Trajkovic-Arsic M, Qin N, Pauck D, Winkelkotte AM, Marquardt V, Sander F, Hassiepen C, Kaufhold A, Meyer FD, Kleinesudeik L, Schramm A, Fulda S, Siveke JT, Borkhardt A, Weller M, Roth P, Reifenberger G, Remke M, Bl?mel L, Wolter M, Lim JKM, Melcher M, Langini M, Stefanski A, Steltgens S, Seibt A, Hain A, M?nk C, Knobbe-Thomsen CB, Fischer U, Leprivier G, St?hler K, Distelmaier F. The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma. Cell Death Dis. 2021 09 28; 12(10):885. PMID: 34584066; PMCID: PMC8478910.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    58. Dinkelbach L, Hillebrecht M, Adams O, Dechert O, Trocan L, Neubert J, Borkhardt A, B?tticher B, Jan?en G. High rate of clinically unrecognized SARS-CoV-2 infections in pediatric palliative care patients. Eur J Pediatr. 2022 Feb; 181(2):847-851. PMID: 34467455; PMCID: PMC8408038.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    59. van Tilburg CM, Pfaff E, Pajtler KW, Fiesel P, Jones BC, Balasubramanian GP, Stark S, Johann PD, Blattner-Johnson M, Schramm K, Dikow N, Hirsch S, Sutter C, Grund K, von Stackelberg A, Kulozik AE, Lissat A, Borkhardt A, Meisel R, Reinhardt D, Klusmann JH, Fleischhack G, Tippelt S, von Schweinitz D, Schmid I, Calaminus G, Vorwerk P, Graf N, Westermann F, Fischer M, Eggert A, Nathrath M, Hecker-Nolting S, Schneider DT, Brecht IB, Ketteler P, Fulda S, Koscielniak E, Meister MT, Scheer M, Hettmer S, Schwab M, Tremmel R, Hutter C, Gerber NU, Lohi O, Kazanowska B, Kattamis A, Filippidou M, Milde T, Wolf S, Reuss D, Sahm F, von Deimling A, Dirksen U, Freitag A, Witt R, Lichter P, Kopp-Schneider A, Jones DTW, Capper D, Pfister SM, Witt O, Langenberg KPS, Kramm CM, von Bueren AO, Burkhardt B, W??mann W, Fr?hwald MC, ?ra I, Goemans B, Zwaan CM, J?ger N, Molenaar JJ. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov. 2021 11; 11(11):2764-2779. PMID: 34373263.
      Citations: 56     Fields:    Translation:Humans
    60. Hanl M, Hey-Hawkins E, Hansen FK, Selg C, Sch?ler A, Schliehe-Diecks J, Sinatra L, Borkhardt A, S?rosi MB, Bhatia S. Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile. Chem Sci. 2021 Sep 15; 12(35):11873-11881. PMID: 34659728; PMCID: PMC8442681.
      Citations: 4     
    61. Loizou L, Demetriou A, Erdmann F, Borkhardt A, Brozou T, Sharp L, McNally R. Increasing incidence and survival of paediatric and adolescent thyroid cancer in Cyprus 1998-2017: A population-based study from the Cyprus Pediatric Oncology Registry. Cancer Epidemiol. 2021 10; 74:101979. PMID: 34247065.
      Citations: 1     Fields:    Translation:Humans
    62. Janssen S, Zeus M, Laws HJ, Fischer U, Borkhardt A, Oommen PT. Results from a?pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis. Z Rheumatol. 2023 Mar; 82(2):123-133. PMID: 34196794; PMCID: PMC9981501.
      Citations: 4     Fields:    Translation:Humans
    63. Wellbrock M, Spix C, Grabow D, Borkhardt A, Zeeb H, Erdmann F. 28-year incidence and time trends of childhood leukaemia in former East Germany compared to West Germany after German reunification: A study from the German Childhood Cancer Registry. Cancer Epidemiol. 2021 08; 73:101968. PMID: 34174725.
      Citations: 4     Fields:    Translation:Humans
    64. Lausberg E, Dewulf JP, Wiame E, Salvarinova R, van Karnebeek CD, Klemm P, Ohl K, Mull M, Braunschweig T, Weis J, Sommer CJ, Stollbrink-Peschgens C, Choukair D, Oommen PT, Borkhardt A, Wagner N, Meyer R, Eggermann T, Begemann M, Van Schaftingen E, Tenbrock K, van den Heuvel L, Elbracht M, Kurth I, Kraft F, Gie?elmann S, Holz A, Demuth S, Haase C, Debray FG, Libioulle C, Surowy H, Wieczorek D, H?usler M. C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation. J Clin Invest. 2021 06 15; 131(12). PMID: 33945503; PMCID: PMC8203463.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    65. Kleinheinz K, Wagener R, Bernhart SH, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Bergmann AK, Bieg M, Binder H, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Hansmann ML, Hovestadt V, Huang B, Kerssemakers JNA, Korbel JO, Lawerenz C, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Loeffler M, Eils R, Klapper W, Hoffmann S, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Schlesner M, Siebert R, H?bschmann D, L?pez C, Beekman R, Borkhardt A, Borst C, Haas S, Hoell JI, Hummel M, J?ger-Schmidt C, Kube D, Lenze D, Mart?n-Subero JI, M?ller P, Tr?mper L, K?ppers R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 07; 35(7):2002-2016. PMID: 33953289; PMCID: PMC8257491.
      Citations: 24     Fields:    Translation:HumansCells
    66. Rickert D, Bartl J, Picard D, Bernardi F, Qin N, Lovino M, Meyer FD, Varlet P, Dufour C, Borkhardt A, Reifenberger G, Ayrault O, Remke M, Puget S, Mahoungou Koumba I, Beez T, Fischer U. Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma. Acta Neuropathol. 2021 06; 141(6):975-978. PMID: 33866410; PMCID: PMC8113310.
      Citations: 11     Fields:    Translation:HumansCells
    67. Bartenhagen C, Attarbaschi A, Classen CF, Kontny U, Wagener R, Taeubner J, Walter C, Yasin L, Alzoubi D, Hauer J, Fischer U, Dugas M, Kuhlen M, Borkhardt A, Brozou T. Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer. Eur J Hum Genet. 2021 08; 29(8):1301-1311. PMID: 33840814; PMCID: PMC8385053.
      Citations: 17     Fields:    Translation:Humans
    68. Yoshimi A, Cario H, Fisch A, Gross-Wieltsch U, Timmermann K, Kontny U, Lobitz S, Schmid I, Uetz B, Borkhardt A, Hohnecker A, Metzler M, Karall D, Niemeyer CM, Gr?nert SC, Odenthal HS, H?ll T, R?tig A, L?cke T, Strau? G. Haematological characteristics and spontaneous haematological recovery in Pearson syndrome. Br J Haematol. 2021 06; 193(6):1283-1287. PMID: 33837965.
      Citations: 2     Fields:    Translation:Humans
    69. Kather JN, Lang KS, Werner J, Kronberg RM, Stachura P, Ostermann PN, M?ller L, Schaal H, Bhatia S, Borkhardt A, Pandyra AA, Lang PA. Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2. Viruses. 2021 04 02; 13(4). PMID: 33918368; PMCID: PMC8066066.
      Citations: 4     Fields:    Translation:AnimalsCells
    70. Hansen FK, Pflieger M, S?nnichsen M, Horstick-Muche N, Yang J, Schliehe-Diecks J, Sch?ler A, Borkhardt A, Hamacher A, Kassack MU, Bhatia S, Kurz T. Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity. ChemMedChem. 2021 06 07; 16(11):1798-1803. PMID: 33629513; PMCID: PMC8251746.
      Citations: 1     Fields:    Translation:HumansCells
    71. Rebmann V, Horn PA, Reusing SB, Manser AR, Groeneveld-Krentz S, Meisel R, Karawajew L, Borkhardt A, Uhrberg M, Babor F. HLA-E expression constitutes a novel determinant for ALL disease monitoring following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2021 07; 56(7):1723-1727. PMID: 33658648; PMCID: PMC8263342.
      Citations: 1     Fields:    Translation:Humans
    72. Hein D, Borkhardt A, Fischer U. Genomic Inverse PCR for Screening of Preleukemic Cells in Newborns (GIPFEL Technology). Methods Mol Biol. 2021; 2185:113-134. PMID: 33165846.
      Citations: 1     Fields:    Translation:HumansCells
    73. Nieper P, Pfeiffer P, Holzem A, Kochanek M, Kisis I, Pelzer BW, da Palma Guerreiro A, Riabinska A, Wiederstein J, Deckert M, Frenzel LP, Sander S, Brunn A, Lohneis P, Persigehl T, Peifer M, Knittel G, Klein S, Ryan JA, Klatt AR, Pasqualucci L, Melnick AM, Montesinos-Rongen M, Kashkar H, Letai A, Reinhardt HC, Fl?mann R, Rehk?mper T, Bhatia S, Ahlert H, Hauer J, Reimann M, Kr?ger M, Altm?ller J, B?guelin W, B?ttner R, Borkhardt A, Schmitt CA. An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov. 2021 01; 2(1):70-91. PMID: 33447829; PMCID: PMC7806186.
      Citations: 18     Fields:    Translation:Animals
    74. Alves Avelar LA, Schrenk C, S?nnichsen M, Hamacher A, Hansen FK, Schliehe-Diecks J, Borkhardt A, Bhatia S, Kassack MU, Kurz T. Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors. Eur J Med Chem. 2021 Feb 05; 211:113095. PMID: 33360560.
      Citations: 2     Fields:    Translation:Humans
    75. Niehues T, Bucher M, Endesfelder D, Roessler U, Borkhardt A, D?ckers G, Kirlum HJ, Lankisch P, Oommen PT, R?be CE, Baumgartner I, Bunk F, Moertl S, Hornhardt S, Gomolka M. Analysis of chromosomal aberrations and ?H2A.X foci to identify radiation-sensitive ataxia-telangiectasia patients. Mutat Res Genet Toxicol Environ Mutagen. 2021 Jan-Feb; 861-862:503301. PMID: 33551102.
      Citations: 2     Fields:    Translation:HumansCells
    76. Jamra RA, Muschke P, Popp B, Zenker M, F?hrenbach M, Borkhardt A, Brozou T, Rey LK, Schaper J, Surowy H, Zweier C, Wieczorek D, Redler S. QRICH1 variants in Ververi-Brady syndrome-delineation of the genotypic and phenotypic spectrum. Clin Genet. 2021 01; 99(1):199-207. PMID: 33009816.
      Citations: 4     Fields:    Translation:Humans
    77. Auer F, Raboso-Gallego J, De Las Rivas J, Hauer J, Vicente-Due?as C, Janssen S, Oldenburg M, Gonz?lez-Herrero I, Casado-Garc?a A, Isidro-Hern?ndez M, Westhoff P, Pandyra AA, Hein D, G?ssling KL, Alonso-L?pez D, Bhatia S, Garc?a-Criado FJ, Garc?a-Cenador MB, Weber APM, K?hrer K, Fischer U, S?nchez-Garc?a I, Borkhardt A. An intact gut microbiome protects genetically predisposed mice against leukemia. Blood. 2020 10 29; 136(18):2003-2017. PMID: 32911536; PMCID: PMC7694022.
      Citations: 44     Fields:    Translation:Animals
    78. Schoeder CT, Sinatra L, Bandolik JJ, Roatsch M, S?nnichsen M, Hamacher A, Sch?ler A, Borkhardt A, Meiler J, Bhatia S, Kassack MU, Hansen FK. Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs). Angew Chem Int Ed Engl. 2020 12 07; 59(50):22494-22499. PMID: 32780485; PMCID: PMC7756583.
      Citations: 21     Fields:    Translation:HumansCells
    79. Liu W, Stachura P, Xu HC, Bhatia S, Borkhardt A, Lang PA, Pandyra AA. Senescent Tumor CD8+ T Cells: Mechanisms of Induction and Challenges to Immunotherapy. Cancers (Basel). 2020 Sep 30; 12(10). PMID: 33008037; PMCID: PMC7601312.
      Citations: 6     
    80. Yang JJ, Ikawa T, Fischer U, Hein D, Vicente-Due?as C, Borkhardt A, S?nchez-Garc?a I. Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and Leukemia. Blood Cancer Discov. 2020 11; 1(3):224-233. PMID: 33392513; PMCID: PMC7774874.
      Citations: 8     Fields:    Translation:HumansCells
    81. Wolfs TFW, Attarbaschi A, Bernardo ME, Bomken S, Borkhardt A, Bourquin JP, Dufour C, Gennery A, Grainger J, Hasle H, Hrusak O, Izraeli S, Trka J, Balduzzi A, Mechinaud F, Vormoor J. COVID-19 - Impact on Childhood Haematology Patients. Hemasphere. 2020 Oct; 4(5):e465. PMID: 32984769; PMCID: PMC7489725.
      Citations: 4     
    82. Osko JD, Hauer J, Christianson DW, Re?ing N, S?nnichsen M, Sch?ler A, Schliehe-Diecks J, Skerhut A, Borkhardt A, Kassack MU, Bhatia S, Hansen FK. Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 2020 09 24; 63(18):10339-10351. PMID: 32803970; PMCID: PMC7762828.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    83. Kloetgen A, Schuschel K, Klusmann JH, McHardy AC, Duggimpudi S, Hezaveh K, Picard D, Schaal H, Remke M, Borkhardt A, Hoell JI. YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA. Int J Mol Sci. 2020 Jun 23; 21(12). PMID: 32585856; PMCID: PMC7352269.
      Citations: 7     Fields:    Translation:HumansCells
    84. Hauer J, Auer F, Fischer U, Borkhardt A. Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia. Leukemia. 2020 08; 34(8):2217-2219. PMID: 32555367; PMCID: PMC7301049.
      Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
    85. Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mischke K, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Eyrich M, Mauz-K?rholz C, Meisel R, M?ller I, Schlegel PG, Borkhardt A. Correction: Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial. Leukemia. 2020 05; 34(5):1486. PMID: 31768014.
      Citations:    Fields:    
    86. Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Alonso MEV, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Conter V, Stary J, Schrappe M, Rives S, Del Pozo Carlavilla M, Dom?nguez-Pinilla N, Escherich G, Lauten M, Ottoffy G, Felice MS, Buldini B. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Eur J Cancer. 2020 06; 132:11-16. PMID: 32305831; PMCID: PMC7141482.
      Citations: 85     Fields:    Translation:HumansCellsPHPublic Health
    87. Hein D, Borkhardt A, Fischer U. Insights into the prenatal origin of childhood acute lymphoblastic leukemia. Cancer Metastasis Rev. 2020 03; 39(1):161-171. PMID: 31902036; PMCID: PMC7098935.
      Citations: 26     Fields:    Translation:Humans
    88. Delgado P, Walter C, Bartenhagen C, Orfao A, Blanco O, Rivas JL, Dugas M, Ramiro AR, Rodr?guez-Hern?ndez G, Opitz FV, ?lvarez-Prado ?F, Gonz?lez-Herrero I, Auer F, Fischer U, Janssen S, Raboso-Gallego J, Casado-Garc?a A, Alonso-L?pez D, Tena-D?vila SG, M?schen M, Criado FJG, Cenador MBG, Vicente-Due?as C, Hauer J, Sanchez-Garcia I, Borkhardt A. Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID. Nat Commun. 2019 12 05; 10(1):5563. PMID: 31804490; PMCID: PMC6895129.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    89. Schramm F, Zur Stadt U, Zimmermann M, Jorch N, Pekrun A, Borkhardt A, Imschweiler T, Christiansen H, Schmid I, Feuchtinger T, Beron G, Horstmann MA, Janka-Schaub GE, Escherich G, Faber J, den Boer ML, Pieters R. Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity. Blood Adv. 2019 11 26; 3(22):3688-3699. PMID: 31765480; PMCID: PMC6880907.
      Citations: 13     Fields:    Translation:Humans
    90. Kloetgen A, Borkhardt A, Hoell JI, McHardy AC, M?nch PC. Corrigendum to: Biochemical and bioinformatic methods for elucidating the role of RNA-protein interactions in posttranscriptional regulation. Brief Funct Genomics. 2019 11 19; 18(6):433. PMID: 31169895; PMCID: PMC6920523.
      Citations: 1     Fields:    
    91. Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Burdach S, Hansmann ML, Mall G, Klapper W, Merseburg A, Persigehl T, Wunderlich FT, Peifer M, Beleggia F, Reinhardt HC, W??mann W, Borkhardt A, Rosenwald A, Perner S, Kr?ger M, Gr?ll H, Uterm?hlen O, B?ttner R. ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020 03; 34(3):771-786. PMID: 31690822.
      Citations: 7     Fields:    Translation:AnimalsCells
    92. Bader P, Borkhardt A, Cario G, Escherich G, Sramkova L, Attarbaschi A, Bourquin JP, Peters C, ALL-REZ BFM Trial Group, Eckert C, Groeneveld-Krentz S, Kirschner-Schwabe R, Hagedorn N, Chen-Santel C, Panzer-Gr?mayer R, Astrahantseff K, Eggert A, Henze G, von Stackelberg A. Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics. J Clin Oncol. 2019 12 20; 37(36):3493-3506. PMID: 31644328.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    93. Demir S, Stanulla M, Schrappe M, Zur Stadt U, Bader P, Strahm B, Alten J, Moericke A, Escherich G, Thiele R, McHardy AC, Peters C, Hoell JI, Ginzel S, Kuhlen M, Kloetgen A, Gombert M, Fischer U, Hein D, Babor F, Schuster F, von Stackelberg A, Bornhauser B, Bourquin JP, Krause S, Enczmann J, Meyer LH, Eckert C, Borkhardt A, Meisel R. Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets. Blood Adv. 2019 10 22; 3(20):3143-3156. PMID: 31648313; PMCID: PMC6849953.
      Citations: 2     Fields:    Translation:HumansCells
    94. Dreisig K, Metzler M, Izraeli S, Schmiegelow K, Hein D, Borkhardt A, Fischer U. The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ?0.6% of healthy newborns. Blood. 2019 10 17; 134(16):1355-1358. PMID: 31434706; PMCID: PMC7005361.
      Citations: 22     Fields:    Translation:Humans
    95. Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mischke K, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Eyrich M, Mauz-K?rholz C, Meisel R, M?ller I, Schlegel PG, Borkhardt A. Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial. Leukemia. 2020 02; 34(2):613-624. PMID: 31578451.
      Citations: 9     Fields:    
    96. Taha MS, Brenner D, Lang KS, Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Herebian D, Mayatepek E, Ahmadian MR, Keitel V, Wieczorek D, H?ussinger D, Pandyra AA, Lang PA. Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury. Gut. 2020 01; 69(1):133-145. PMID: 31409605; PMCID: PMC6943250.
      Citations: 6     Fields:    Translation:AnimalsCells
    97. Rosenbaum T, Pietsch T, Chiu C, Loth S, Kuhlen M, Ginzel S, Schaper J, Borkhardt A, Hoell JI. Mutated SON putatively causes a cancer syndrome comprising high-risk medulloblastoma combined with caf?-au-lait spots. Fam Cancer. 2019 07; 18(3):353-358. PMID: 30680470.
      Citations: 3     Fields:    Translation:Humans
    98. Varon M, Levy T, Mazor G, Ben David H, Marciano R, Krelin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Remke M, Rotblat B, Borkhardt A, Reifenberger G, Leprivier G. The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Int J Cancer. 2019 12 15; 145(12):3402-3413. PMID: 31081944.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    99. Peters C, Glogova E, Sauer M, Cario G, Gruhn B, Horn PA, Kremens B, Mytilineos J, Pichler H, Stachel D, Strahm B, Escherich G, Zimmermann M, Schrappe M, Bader P, Babor F, Manser AR, P?tschger U, Ahlmann M, Feuchtinger T, G?ng?r T, Lang P, Mezger M, M?ller I, Oevermann L, Scherenschlich N, Schuster FR, Siepermann M, W?ssmann W, Borkhardt A, Eckert C, Uhrberg M, Meisel R. Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL. Bone Marrow Transplant. 2019 11; 54(11):1847-1858. PMID: 31089287.
      Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
    100. Kohns Vasconcelos M, Laws HJ, Borkhardt A, Neubert J. Medical history and clinical examinations are insufficient to exclude vertical human immunodeficiency virus transmission in healthy, at-risk adolescents. Acta Paediatr. 2019 06; 108(6):994-997. PMID: 30901119.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    101. Nebral K, Ganmore I, Haas OA, Izraeli S, Trka J, Hu J, Lin M, Gertzen CGW, Bhatia S, Fischer U, Kuhlen M, Gohlke H, Borkhardt A, Hauer J, Auer F. JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility. Leukemia. 2019 09; 33(9):2331-2335. PMID: 30967616; PMCID: PMC6756027.
      Citations: 4     Fields:    Translation:HumansCells
    102. Eiz-Vesper B, G?ssling KL, Fouz H, Kyrillopoulou O, Aubin M, Maecker-Kolhoff B, Adams O, Borkhardt A, Babor F, Schuster FR, Siepermann M, Schumm M, Lang P, Meisel R. Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After a?TCR-CD19-Depleted Stem Cell Transplantation. Clin Infect Dis. 2019 04 08; 68(8):1406-1409. PMID: 30357314.
      Citations: 1     Fields:    Translation:HumansCells
    103. Kleinheinz K, Aukema SM, Rohde M, Bernhart SH, Wagener R, Toprak UH, Raimondi F, Kreuz M, Waszak SM, Huang Z, Sieverling L, Paramasivam N, Seufert J, Sungalee S, Russell RB, Bausinger J, Kretzmer H, Ammerpohl O, Bergmann AK, Binder H, Brors B, Claviez A, Doose G, Feuerbach L, Haake A, Hansmann ML, Korbel JO, Lawerenz C, Radlwimmer B, Richter J, Rosenstiel P, Schilhabel MB, Stein H, Stilgenbauer S, Stadler PF, Szczepanowski M, Weniger MA, Zapatka M, Eils R, Lichter P, Loeffler M, Klapper W, ICGC MMML-Seq Consortium, Hoffmann S, Schlesner M, Siebert R, L?pez C, H?bschmann D, Borkhardt A, Hoell J, Hummel M, Lenze D, Rosenwald A, M?ller P, Tr?mper L, K?ppers R, Burkhardt B. Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. Nat Commun. 2019 03 29; 10(1):1459. PMID: 30926794; PMCID: PMC6440956.
      Citations: 51     Fields:    Translation:HumansCells
    104. Mazor G, Levin L, Picard D, Ahmadov U, Remke M, Rotblat B, Car?n H, Borkhardt A, Reifenberger G, Leprivier G. The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Cell Death Dis. 2019 03 13; 10(3):246. PMID: 30867410; PMCID: PMC6416247.
      Citations: 78     Fields:    Translation:HumansCells
    105. Bomken S, van der Werff Ten Bosch J, Attarbaschi A, Bacon CM, Boztug K, Hauck F, Lammens T, Quinti I, Seidel MG, Warnatz K, Wehr C, Lankester AC, Gennery AR, Borkhardt A, Fischer U, Kuiper RP, Loeffen J, Neven B, Pan-Hammarstr?m Q. Current Understanding and Future Research Priorities in Malignancy Associated With Inborn Errors of Immunity and DNA Repair Disorders: The Perspective of an Interdisciplinary Working Group. Front Immunol. 2018; 9:2912. PMID: 30619276; PMCID: PMC6299915.
      Citations: 27     Fields:    Translation:Humans
    106. Osko JD, Christianson DW, Bhatia S, Krieger V, Groll M, Re?ing N, Ahlert H, Borkhardt A, Kurz T, Hauer J, Hansen FK. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 11 21; 61(22):10299-10309. PMID: 30365892; PMCID: PMC6249066.
      Citations: 22     Fields:    Translation:HumansCells
    107. Paltiel O, Lemeshow S, Phillips GS, Tikellis G, Linet MS, Ponsonby AL, Magnus P, Olsen SF, Klebanoff M, Golding J, Herceg Z, Ghantous A, Hirst JE, Borkhardt A, Ward MH, Dwyer T, H?berg SE, Granstr?m C, Holst S?egaard S. The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C). Int J Cancer. 2019 01 01; 144(1):26-33. PMID: 30098208.
      Citations: 6     Fields:    Translation:Humans
    108. Fleckenstein B, Stepensky P, Schipp C, Schl?termann D, H?nscheid A, Nabhani S, H?ll J, Oommen PT, Ginzel S, Stork B, Borkhardt A, Fischer U. EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency. Front Immunol. 2018; 9:2400. PMID: 30386345; PMCID: PMC6198654.
      Citations: 13     Fields:    Translation:HumansCells
    109. Siebert R, Kuhlen M, Taeubner J, Brozou T, Wieczorek D, Borkhardt A. Family-based germline sequencing in children with cancer. Oncogene. 2019 02; 38(9):1367-1380. PMID: 30305723; PMCID: PMC6755997.
      Citations: 17     Fields:    Translation:Humans
    110. Gennery AR, Ghosh S, Drexler I, Bhatia S, Adler H, Borkhardt A. Corrigendum: Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight? Front Immunol. 2018; 9:2197. PMID: 30323808; PMCID: PMC6174291.
      Citations: 1     Fields:    
    111. Taeubner J, Wieczorek D, Yasin L, Brozou T, Borkhardt A, Kuhlen M. Penetrance and Expressivity in Inherited Cancer Predisposing Syndromes. Trends Cancer. 2018 11; 4(11):718-728. PMID: 30352675.
      Citations: 16     Fields:    Translation:Humans
    112. Martignetti L, Calzone L, Brabetz S, Montagud A, Sta A, Dingli F, Arras G, Rivera J, Loew D, Dufour C, Leboucher S, Sieber L, Chavez L, Okonechnikov K, Sharma T, Thatikonda V, Bourdeaut F, Ramaswamy V, Korshunov A, Poullet P, Taylor MD, Kool M, Pfister SM, Kawauchi D, Barillot E, Forget A, Puget S, Picard D, Liva S, Besnard A, Lacombe J, Pag?s M, Varlet P, Yu H, Mercier AL, Indersie E, Chivet A, Beccaria K, Gombert M, Meyer FD, Qin N, Bartl J, Pouponnot C, Borkhardt A, Reifenberger G, Remke M, Ayrault O. Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell. 2018 09 10; 34(3):379-395.e7. PMID: 30205043.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    113. Duggimpudi S, Kloetgen A, Maney SK, M?nch PC, Hezaveh K, Shaykhalishahi H, Hoyer W, McHardy AC, Lang PA, Borkhardt A, Hoell JI. Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling. J Biol Chem. 2018 10 05; 293(40):15359-15369. PMID: 30126842; PMCID: PMC6177596.
      Citations: 20     Fields:    Translation:HumansCells
    114. Ingenhag D, Reister S, Auer F, Bhatia S, Wildenhain S, Picard D, Remke M, Hoell JI, Kloetgen A, Sohn D, J?nicke RU, Koegler G, Borkhardt A, Hauer J. The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells. Haematologica. 2019 01; 104(1):35-46. PMID: 30093397; PMCID: PMC6312034.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    115. Bhatia S, Borkhardt A, Hauer J, Rodr?guez-Hern?ndez G, Vicente-Due?as C, S?nchez-Garc?a I. T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology. Mol Cell Oncol. 2018; 5(4):e1497860. PMID: 30250933; PMCID: PMC6150050.
      Citations: 1     
    116. Bader P, Sauer M, Gruhn B, Kropshofer G, Lawitschka A, Metzler M, Schrappe M, Schrum J, Schulz A, Schwinger W, Strahm B, Poetschger U, Glogova E, Peters C, Kuhlen M, Albert MH, G?ng?r T, Lang P, Pentek F, Rossig C, Schlegel PG, von Stackelberg A, Suttorp M, Luettichau IT, W??mann W, Borkhardt A, Meisel R. Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial. Br J Haematol. 2018 10; 183(1):104-109. PMID: 30028016.
      Citations: 4     Fields:    Translation:Humans
    117. Hoell JI, Warfsmann J, Distelmaier F, Borkhardt A, Kuhlen M, Jan?en G. Challenges of palliative care in children with inborn metabolic diseases. Orphanet J Rare Dis. 2018 07 09; 13(1):112. PMID: 29986738; PMCID: PMC6038293.
      Citations: 6     Fields:    Translation:Humans
    118. Schramm F, Zimmermann M, Jorch N, Pekrun A, Borkhardt A, Christiansen H, Feuchtinger T, Schmid I, Beron G, Horstmann MA, Escherich G, Imschweiler T, Faber J. Daunorubicin during delayed intensification decreases the incidence of infectious complications - a randomized comparison in trial CoALL 08-09. Leuk Lymphoma. 2019 01; 60(1):60-68. PMID: 29966458.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    119. Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Zipprich G, Heinold M, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Nathrath M, Niemeyer C, Schulte J, Siebert R, Westermann F, Witt H, Kratz CP, Witt O, van Tilburg CM, Fleischhack G, Dirksen U, Rutkowski S, von Hoff K, Wolf S, Klingebiel T, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM, ICGC PedBrain-Seq Project, ICGC MMML-Seq Project, Gr?bner SN, H?bschmann D, Eils J, Gessler M, Wegert J, Bielack S, Richter GH, Molenaar JJ, Vassal G, Burkhardt B, Kramm CM, Fr?hwald M, Koscielniak E, Landgraf P. Author Correction: The landscape of genomic alterations across childhood cancers. Nature. 2018 07; 559(7714):E10. PMID: 29875405.
      Citations: 9     Fields:    
    120. Suttorp M, Schulze P, Glauche I, von Neuhoff N, Metzler M, Sedlacek P, de Bont ESJM, Lausen B, Aleinikova O, Sufliarska S, Kremens B, Berthold F, Klein C, Sykora KW, Kulozik AE, Schrappe M, Nowasz C, Krumbholz M, Tauer JT, Claviez A, Harbott J, Kreipe HH, Schlegelberger B, Thiede C, G?hring G, Balduzzi A, Henze G, Strauss G, Eggert A, Groll AH, Gro?-Wieltsch U, Borkhardt A. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia. 2018 07; 32(7):1657-1669. PMID: 29925908.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    121. Bhatia S, Walter C, Parvin S, Haas O, Woessmann W, Stanulla M, Schrappe M, Dugas M, Natkunam Y, Orfao A, Blanco O, De Las Rivas J, Lossos IS, Borkhardt A, Hauer J, Garc?a-Ram?rez I, Rodr?guez-Hern?ndez G, Gonz?lez-Herrero I, Gonz?lez de Tena-D?vila S, Dom?nguez V, Pintado B, Alonso-L?pez D, Mart?n-Lorenzo A, Jim?nez R, Garc?a Criado FJ, Garc?a Cenador MB, Vicente-Due?as C, S?nchez-Garc?a I. Lmo2 expression defines tumor cell identity during T-cell leukemogenesis. EMBO J. 2018 07 13; 37(14). PMID: 29880602; PMCID: PMC6043907.
      Citations: 25     Fields:    Translation:AnimalsCells
    122. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Kornblau SM, Konopleva M, Pufall MA, Liu GJ, Milne TA, Koeffler HP, Ross TS, Yamamoto KR, Dickins RA, Graeber TG, Ernst T, Hochhaus A, Cazzaniga G, S?nchez-Garc?a I, Borkhardt A, M?schen M. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5. PMID: 29849140.
      Citations:    Fields:    
    123. Vicente-Due?as C, Hauer J, Cobaleda C, Borkhardt A, S?nchez-Garc?a I. Epigenetic Priming in Cancer Initiation. Trends Cancer. 2018 06; 4(6):408-417. PMID: 29860985.
      Citations: 44     Fields:    Translation:Humans
    124. Gennery AR, Ghosh S, Drexler I, Bhatia S, Adler H, Borkhardt A. Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight? Front Immunol. 2018; 9:979. PMID: 29867957; PMCID: PMC5951928.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    125. Bhatia S, Ahlert H, Stein S, Lang F, Ernst T, Kunkel H, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Hauer J, Diedrich D, Frieg B, Bopp B, Zang T, Kr?ger T, K?gler G, Krieg A, L?deke S, Rodrigues Moita AJ, Kassack MU, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response. Blood. 2018 07 19; 132(3):307-320. PMID: 29724897; PMCID: PMC6225350.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    126. Krull K, Kunstreich M, Bronsema A, Bleckmann K, Classen CF, Erdlenbruch B, Jorch N, Kolb R, Leipold A, Moser O, Prokop A, Steinbach D, Klasen-Sansone J, Klee D, Escherich G, Moericke A, Schrappe M, Borkhardt A, Kuhlen M, Scheurlen W. Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy. Leuk Lymphoma. 2019 01; 60(1):78-84. PMID: 29718744.
      Citations: 7     Fields:    Translation:Humans
    127. Hoell JI, Weber HL, Balzer S, Danneberg M, Gagnon G, Trocan L, Borkhardt A, Kuhlen M, Jan?en G. Advance care planning and outcome in pediatric palliative home care. Oncotarget. 2018 Apr 03; 9(25):17867-17875. PMID: 29707152; PMCID: PMC5915160.
      Citations: 6     Fields:    
    128. Kuhlen M, Borkhardt A. Trio sequencing in pediatric cancer and clinical implications. EMBO Mol Med. 2018 04; 10(4). PMID: 29507082; PMCID: PMC5887902.
      Citations: 11     Fields:    Translation:Humans
    129. van de Loo K, Balzer S, MacKenzie CR, Boemers TM, Ortmann M, Borkhardt A, Kuhlen M, Schaper J, Laws HJ. Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report. BMC Infect Dis. 2018 03 05; 18(1):105. PMID: 29506484; PMCID: PMC5839039.
      Citations:    Fields:    Translation:HumansCells
    130. TRANSCALL Consortium, International BFM Study Group, Stanulla M, Dagdan E, Zaliova M, M?ricke A, Palmi C, Cazzaniga G, Eckert C, Te Kronnie G, Bourquin JP, Bornhauser B, Koehler R, Bartram CR, Ludwig WD, Bleckmann K, Groeneveld-Krentz S, Schewe D, Junk SV, Hinze L, Klein N, Kratz CP, Biondi A, Borkhardt A, Kulozik A, Muckenthaler MU, Basso G, Valsecchi MG, Izraeli S, Petersen BS, Franke A, D?rge P, Steinemann D, Haas OA, Panzer-Gr?mayer R, Cav? H, Houlston RS, Cario G, Schrappe M, Zimmermann M. IKZF1plus Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. J Clin Oncol. 2018 04 20; 36(12):1240-1249. PMID: 29498923.
      Citations: 106     Fields:    Translation:Humans
    131. Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Zipprich G, Heinold M, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Nathrath M, Niemeyer C, Schulte J, Siebert R, Westermann F, Witt H, ICGC PedBrain-Seq Project, ICGC MMML-Seq Project, Kratz CP, Witt O, van Tilburg CM, Fleischhack G, Dirksen U, Rutkowski S, von Hoff K, Wolf S, Klingebiel T, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM, Gr?bner SN, H?bschmann D, Eils J, Gessler M, Wegert J, Bielack S, Richter GH, Molenaar JJ, Vassal G, Burkhardt B, Kramm CM, Fr?hwald M, Koscielniak E, Landgraf P. The landscape of genomic alterations across childhood cancers. Nature. 2018 03 15; 555(7696):321-327. PMID: 29489754.
      Citations: 589     Fields:    Translation:Humans
    132. Auer F, Chan LN, Bartenhagen C, Dugas M, Gombert M, Ginzel S, Rivas JL, Borkhardt A, Hauer J, Mart?n-Lorenzo A, Garc?a-Ram?rez I, Gonz?lez-Herrero I, Rodr?guez-Hern?ndez G, Blanco O, Orfao A, Alonso-L?pez D, Garc?a-Cenador MB, Garc?a-Criado FJ, M?schen M, S?nchez-Garc?a I, Vicente-Due?as C. Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL. Cancer Res. 2018 05 15; 78(10):2669-2679. PMID: 29490943; PMCID: PMC6245574.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    133. Hain A, Kr?mer M, Linka RM, Nakhaei-Rad S, Ahmadian MR, H?ussinger D, Borkhardt A, M?nk C. IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells. Sci Rep. 2018 02 16; 8(1):3217. PMID: 29453458; PMCID: PMC5816632.
      Citations: 5     Fields:    Translation:HumansCells
    134. Namineni S, Shaabani N, Trilling M, van Rooijen N, Crocker PR, Tanaka M, Heikenwalder M, Mak TW, Brenner D, Pandyra AA, Lang KS, Shinde PV, Xu HC, Maney SK, Kloetgen A, Zhuang Y, Honke N, Bellora N, Doerrenberg M, Pozdeev VI, Scheu S, Pfeffer K, Duggimpudi S, Knolle P, Ruland J, Hoell JI, Borkhardt A, H?ussinger D, Lang PA. Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J Virol. 2018 02 01; 92(3). PMID: 29142134; PMCID: PMC5774891.
      Citations: 11     Fields:    Translation:AnimalsCells
    135. Olsen M, Stanulla M, Slany R, Schmiegelow K, Sch?fer D, L?hnemann D, Borkhardt A, Fischer U. Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening. Blood. 2018 02 15; 131(7):821-826. PMID: 29311095; PMCID: PMC5909885.
      Citations: 50     Fields:    Translation:Humans
    136. Wimmer K, Fauth C, Felsberg J, Riemer J, Taeubner J, Muleris M, Lascols O, Colas C, Brozou T, Gombert M, Ginzel S, Hoell JI, Borkhardt A, Kuhlen M. Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6. Eur J Hum Genet. 2018 03; 26(3):440-444. PMID: 29302048; PMCID: PMC5839041.
      Citations: 10     Fields:    Translation:HumansCells
    137. Brozou T, Taeubner J, Velleuer E, Dugas M, Wieczorek D, Borkhardt A, Kuhlen M. Correction to: Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES. Eur J Pediatr. 2018 01; 177(1):61. PMID: 29105029; PMCID: PMC6828017.
      Citations:    Fields:    
    138. Taeubner J, Brozou T, Qin N, Bartl J, Ginzel S, Schaper J, Felsberg J, Fulda S, Vokuhl C, Borkhardt A, Kuhlen M. Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations. Eur J Hum Genet. 2018 01; 26(1):137-142. PMID: 29230040; PMCID: PMC5839031.
      Citations: 9     Fields:    Translation:Humans
    139. Kuhlen M, Willasch AM, Wachowiak J, Yaniv I, Ifversen M, Sedlacek P, Lang P, Bader P, Sufliarska S, Strahm B, Hoell JI, Borkhardt A, Klingebiel T, Schrappe M, Glogova E, Poetschger U, Meisel R, Peters C, Dalle JH, Guengoer T, Balduzzi A, von Luettichau I, von Stackelberg A. Outcome of relapse after allogeneic HSCT in children with ALL enrolled in the ALL-SCT 2003/2007 trial. Br J Haematol. 2018 01; 180(1):82-89. PMID: 29193007.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    140. Schmidt E, Fischer U, Biskup W, Haferlach C, Meisel R, Kuhlen M, Borkhardt A. Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome. Klin Padiatr. 2017 11; 229(6):352-354. PMID: 29132167.
      Citations:    Fields:    Translation:Humans
    141. Offenmueller S, Classen CF, Corbacioglu S, Dirksen U, Ebetsberger-Dachs G, Heinzerling L, Jorch N, Kuhlen M, Lawlor J, Streiter M, Brecht I, Leiter U, Bernbeck B, Garbe C, Eigentler T, Borkhardt A, Niggli F, Schneider DT. Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP). Klin Padiatr. 2017 Nov; 229(6):322-328. PMID: 29017184.
      Citations: 6     Fields:    Translation:Humans
    142. Kuhlen M, Taeubner J, Wieczorek D, Borkhardt A. Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated? Mol Cell Pediatr. 2017 Oct 05; 4(1):8. PMID: 28983852; PMCID: PMC5629188.
      Citations:    
    143. Rodr?guez-Hern?ndez G, Sch?fer D, Gavil?n A, Vicente-Due?as C, Hauer J, Borkhardt A, S?nchez-Garc?a I. Modeling the process of childhood ETV6-RUNX1 B-cell leukemias. Oncotarget. 2017 Nov 24; 8(60):102674-102680. PMID: 29254279; PMCID: PMC5731989.
      Citations: 6     Fields:    
    144. Hoell JI, Warfsmann J, Balzer S, Borkhardt A, Janssen G, Kuhlen M. End-of-life care in children with hematologic malignancies. Oncotarget. 2017 Oct 27; 8(52):89939-89948. PMID: 29163800; PMCID: PMC5685721.
      Citations: 6     Fields:    
    145. Brozou T, Taeubner J, Velleuer E, Dugas M, Wieczorek D, Borkhardt A, Kuhlen M. Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES. Eur J Pediatr. 2018 Jan; 177(1):53-60. PMID: 28929227; PMCID: PMC5748429.
      Citations: 12     Fields:    Translation:Humans
    146. Auer F, Ingenhag D, Pinkert S, Gombert M, Lin MH, Borkhardt A, Hauer J, Kracker S, Hacein-Bey-Abina S, Cavazzana M, Martin-Lorenzo A, Vicente-Due?as C, S?nchez-Garc?a I. Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells. Oncotarget. 2017 Sep 29; 8(44):75797-75807. PMID: 29100269; PMCID: PMC5652663.
      Citations: 2     Fields:    
    147. Hoell JI, Warfsmann J, Gagnon G, Trocan L, Balzer S, Oommen PT, Borkhardt A, Kuhlen M, Jan?en G. Palliative care for children with a yet undiagnosed syndrome. Eur J Pediatr. 2017 Oct; 176(10):1319-1327. PMID: 28808789.
      Citations: 9     Fields:    Translation:Humans
    148. Hansson N, Oommen-Halbach A, Borkhardt A, Fangerau H. Nobel Prize nominees hundred years ago: Abraham Jacobi (1830-1919) and Otto Heubner (1843-1926). Eur J Pediatr. 2017 Oct; 176(10):1411-1413. PMID: 28804857.
      Citations: 3     Fields:    
    149. Kuhlen M, Bleckmann K, Schrappe M, Vieth S, Escherich G, Bronsema A, Vonalt A, Queudeville M, Zwaan CM, Ebinger M, Debatin KM, Klingebiel T, Koscielniak E, Rossig C, Burkhardt B, Kolb R, Borkhardt A, M?ricke A, Eckert C, von Stackelberg A, Chen-Santel C. Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy. Br J Haematol. 2017 10; 179(2):272-283. PMID: 28771662.
      Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
    150. Michalsky N, Borkhardt A, Neubert J, Laws HJ, Jensen B, L?bke N. HIV-1 Subtype Diversity and Prevalence of Primary Drug Resistance in a Single-Center Pediatric Cohort in Germany. Intervirology. 2016; 59(5-6):301-306. PMID: 28675900.
      Citations: 2     Fields:    
    151. Amberger DC, Doraneh-Gard F, Sutanto W, Guenther T, Schmohl J, Schuster F, Salih H, Babor F, Borkhardt A, Schmetzer H, Boeck CL. Significance of Frequencies, Compositions, and/or Antileukemic Activity of (DC-stimulated) Invariant NKT, NK and CIK Cells on the Outcome of Patients With AML, ALL and CLL. J Immunother. 2017 Jul/Aug; 40(6):224-248. PMID: 28557814.
      Citations: 24     Fields:    Translation:HumansCells
    152. Fremerey J, Balzer S, Brozou T, Schaper J, Borkhardt A, Kuhlen M. Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome. Fam Cancer. 2017 07; 16(3):401-405. PMID: 27896549.
      Citations: 13     Fields:    Translation:Humans
    153. Koch G, G?ssling KL, Schipp C, Fischer U, Babor F, Schuster FR, Dietzel-Dahmen J, Wieczorek D, Borkhardt A, Meisel R, Kuhlen M. Hematopoietic Stem Cell Transplantation in an Infant with Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome. Front Immunol. 2017; 8:773. PMID: 28713390; PMCID: PMC5491950.
      Citations: 7     Fields:    
    154. Bartenhagen C, Dugas M, Blanco O, De Las Rivas J, Rodr?guez-Hern?ndez G, Hauer J, Mart?n-Lorenzo A, Sch?fer D, Garc?a-Ram?rez I, Auer F, Gonz?lez-Herrero I, Ruiz-Roca L, Gombert M, Okpanyi V, Fischer U, Chen C, Bhatia S, Linka RM, Garcia-Suquia M, Rasc?n-Trincado MV, Garcia-Sanchez A, Garc?a-Cenador MB, Garc?a-Criado FJ, Cobaleda C, Alonso-L?pez D, M?schen M, Vicente-Due?as C, S?nchez-Garc?a I, Borkhardt A. Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases. Cancer Res. 2017 08 15; 77(16):4365-4377. PMID: 28630052.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    155. Kuhlen M, Kunstreich M, Krull K, Meisel R, Borkhardt A. Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge. Blood Adv. 2017 Jun 13; 1(14):981-994. PMID: 29296741; PMCID: PMC5737600.
      Citations: 9     Fields:    
    156. Miskin H, Levin C, Postovsky S, Dujovny T, Koren A, Harlev D, Keller B, Warnatz K, Stepensky P, Nabhani S, Schipp C, Bis AM, Auer F, Gombert M, Ginzel S, Borkhardt A, Fischer U. STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds. Clin Immunol. 2017 08; 181:32-42. PMID: 28579554.
      Citations: 29     Fields:    Translation:HumansCells
    157. Schwartzman O, Savino AM, Gombert M, Cario G, Schrappe M, Huang JY, Hameiri-Grossman M, Avigad S, Te Kronnie G, Geron I, Birger Y, Rein A, Zarfati G, Fischer U, Mukamel Z, Stanulla M, Vetere A, Wagner BK, Chen Z, Chen SJ, Tanay A, Borkhardt A, Izraeli S, Palmi C, Eckert C, von Stackelberg A, Biondi A, Cazzaniga G. Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4030-E4039. PMID: 28461505; PMCID: PMC5441776.
      Citations: 35     Fields:    Translation:HumansCells
    158. van den Bruck R, Weil PP, Vogel S, Schuster F, Orth V, Pembaur D, Zirngibl H, Wirth S, Jenke ACW, Postberg J, Boy N, Heringer J, Haege G, Glahn EM, Hoffmann GF, Garbade SF, Burgard P, Staufner C, Hoffmann GF, Seeliger S, Hippe A, Zierk J, Arzideh F, Rascher W, Rauh M, Metzler M, Thieme S, Bandola J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Hedrich CM, Bonifacio E, Berner R, Brenner S, Hammersen J, Has C, Naumann-Bartsch N, Stachel D, Kiritsi D, Metzler M, Bruckner-Tuderman L, Schneider H, Bohne F, Langer D, Cencic R, Eggermann T, Zechner U, Pelletier J, Zepp F, Enklaar T, Prawitt D, Heinsen FA, Franke A, Happle C, Dittrich AM, Hansen G, Fuchs O, von Mutius E, Oliver BG, Paret C, Russo A, Theruvath J, Keller B, El Malki K, Lehmann N, Wingerter A, Neu MA, Aslihan GA, Wagner W, Sommer C, Pietsch T, Seidmann L, Schreiner F, Ackermann M, Michalik M, Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Zimmer A, Woelfle J, Hagenbuchner J, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ, Loges NT, Frommer AT, Wallmeier J, Omran H, Nemes K, Siebert R, Kool M, Hardy H, Refai O, Barwick KES, Zimmerman HH, Baple EL, Crosby AH, Liebau MC, Tews D, Wabitsch M, Fischer-Posovszky P, Westhoff MA, Nonnenmacher L, Langhans J, Schneele L, Trenkler N, Debatin KM, Ziegenhals T, Schreiner P, Juranek S, G?dde D, D?rner J, R?per M, St?rkel S, K?lker S, Chao CM, Yahya F, Moiseenko A, Shrestha A, Ahmadvand N, Quantius J, Wilhelm J, El-Agha E, Zimmer KP, Bellusci S, K?lker S, Prokisch H, M?ller M, Steinkraus H, Wauer R, Lachmann B, Hofmann SR, Hedrich CM, Haeckel R, S?der S, Tardieu M, Pech M, Weckmann M, Kopp MV, Faber J, D?tsch J, Fischer HS, Ullrich TL, B?hrer C, Czernik C, Schmalisch G, Stein R, ?ner-Sieben S, Gimpfl M, Rozman J, Irmler M, Beckers J, De Angelis MH, Roscher A, Wolf E, Ensenauer R, Fr?hwald M, Hasselblatt M, Kordes U, Wang H, Weis J, Cirak S, Hellmuth C, Uhl O, Standl M, Heinrich J, Thiering E, Koletzko B, Bl?mel L, Kerl K, Picard D, Fr?hwald MC, Reifenberger G, Borkhardt A, Hasselblatt M, Remke M. Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016. Mol Cell Pediatr. 2017 May; 4(Suppl 1):5. PMID: 28516419; PMCID: PMC5435609.
      Citations:    
    159. Kunstreich M, Kreth JH, Oommen PT, Schaper J, Karenfort M, Aktas O, Tibussek D, Distelmaier F, Borkhardt A, Kuhlen M. Paraneoplastic limbic encephalitis with SOX1 and PCA2 antibodies and relapsing neurological symptoms in an adolescent with Hodgkin lymphoma. Eur J Paediatr Neurol. 2017 Jul; 21(4):661-665. PMID: 28389060.
      Citations: 10     Fields:    Translation:Humans
    160. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Kornblau SM, Konopleva M, Pufall MA, Liu GJ, Milne TA, Koeffler HP, Ross TS, Yamamoto KR, Dickins RA, Graeber TG, Ernst T, Hochhaus A, Cazzaniga G, S?nchez-Garc?a I, Borkhardt A, M?schen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. PMID: 28192788; PMCID: PMC5621518.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    161. Ripperger T, Bielack SS, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Dirksen U, Erlacher M, Fleischhack G, Gnekow A, Goehring G, Graf N, Hero B, Hettmer S, von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler R, Kerl K, Klingebiel T, Kontny U, Kordes U, Koscielniak E, Kramm CM, Kulozik AE, Lamottke B, Leuschner I, Lohmann DR, Meinhardt A, Metzler M, Moser O, Nathrath M, Niemeyer CM, Nustede R, Pajtler KW, Paret C, Rasche M, Reinhardt D, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, von Bueren AO, Vorwerk P, Witt O, Wlodarski M, Zenker M, Zimmermann S, Pfister SM, Kratz CP, Borkhardt A, Deubzer H, Eckert C, Eggert A, Fr?hwald MC, Hanenberg H, Hauer J, K?rholz D, Kuhlen M, Meyer LH, Rie? O, W?ssmann W. Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. Am J Med Genet A. 2017 Apr; 173(4):1017-1037. PMID: 28168833.
      Citations: 82     Fields:    Translation:Humans
    162. Korn K, Pfister SM, Rinaldi A, Bourquin JP, Hu J, Ensser A, Bartenhagen C, Fischer U, Gombert M, Chen C, Okpanyi V, Hauer J, Eckert C, Dugas M, Borkhardt A. Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing. Haematologica. 2017 05; 102(5):e179-e183. PMID: 28154091; PMCID: PMC5685284.
      Citations: 8     Fields:    Translation:Humans
    163. Krull K, Kunstreich M, Klasen-Sansone J, Kloetgen A, Gruener F, Escherich G, Bleckmann K, Moericke A, Schrappe M, Jorch N, Steinbach D, Classen CF, Guggemos A, Kolb R, Klee D, Borkhardt A, Kuhlen M. Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial. Leuk Lymphoma. 2017 Oct; 58(10):2363-2369. PMID: 28140726.
      Citations: 4     Fields:    Translation:Humans
    164. Kempkes B, Klapper W, Niehues T, Schneider D, Speckmann C, Ghosh S, H?nscheid A, D?ckers G, Ginzel S, Gohlke H, Gombert M, Kuhlen M, Laws HJ, Linka RM, Meisel R, Mielke C, Schindler D, Schuster FR, Borkhardt A. Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency. Haematologica. 2017 02; 102(2):e69-e72. PMID: 27979922; PMCID: PMC5286958.
      Citations: 3     Fields:    Translation:HumansCells
    165. von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L. Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia. J Clin Oncol. 2016 12 20; 34(36):4381-4389. PMID: 27998223.
      Citations: 202     Fields:    Translation:HumansCTClinical Trials
    166. Kuhlen M, Oommen PT, Borkhardt A. Massively Distended Abdomen Caused by Fibromatosis Previously Misdiagnosed as Myxofibrosarcoma. J Oncol Pract. 2016 11; 12(11):1192-1194. PMID: 27858546.
      Citations:    Fields:    Translation:Humans
    167. Kloetgen A, Borkhardt A, Hoell JI, McHardy AC. The PARA-suite: PAR-CLIP specific sequence read simulation and processing. PeerJ. 2016; 4:e2619. PMID: 27812418; PMCID: PMC5088580.
      Citations: 5     Fields:    
    168. Bleckmann K, Stanulla M, Schrappe M, McHardy AC, Doerrenberg M, Kloetgen A, Hezaveh K, W?ssmann W, Borkhardt A, Hoell JI. T-cell acute lymphoblastic leukemia in infants has distinct genetic and epigenetic features compared to childhood cases. Genes Chromosomes Cancer. 2017 02; 56(2):159-167. PMID: 27717083.
      Citations: 10     Fields:    Translation:HumansCells
    169. Kunstreich M, Kummer S, Laws HJ, Borkhardt A, Kuhlen M. Osteonecrosis in children with acute lymphoblastic leukemia. Haematologica. 2016 11; 101(11):1295-1305. PMID: 27742768; PMCID: PMC5394877.
      Citations: 40     Fields:    Translation:Humans
    170. Bhatia S, Daschkey S, Lang F, Borkhardt A, Hauer J. Mouse models for pre-clinical drug testing in leukemia. Expert Opin Drug Discov. 2016 Nov; 11(11):1081-1091. PMID: 27562952.
      Citations: 2     Fields:    Translation:HumansAnimals
    171. Fischbacher D, Merle M, Liepert A, Grabrucker C, Kroell T, Kremser A, Freudenreich M, Kraemer D, Koehne CH, Kolb HJ, Schmid C, Schmetzer HM, Drey?ig J, Schuster F, Borkhardt A. Cytokine Release Patterns in Mixed Lymphocyte Culture (MLC) of T-Cells with Dendritic Cells (DC) Generated from AML Blasts Contribute to Predict anti-Leukaemic T-Cell Reactions and Patients' Response to Immunotherapy. Cell Commun Adhes. 2015 Apr - Dec; 22(2-6):49-65. PMID: 27602789.
      Citations: 4     Fields:    Translation:HumansCells
    172. Wintgens J, Biskup W, Oschlies I, Klapper W, Siebert R, Bens S, Haferlach C, Meisel R, Kuhlen M, Borkhardt A, Gy?rf?s T. Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus. Mol Cell Pediatr. 2016 Dec; 3(1):30. PMID: 27510896; PMCID: PMC5002396.
      Citations: 2     
    173. Kuhlen M, Hoell JI, Gagnon G, Balzer S, Oommen PT, Borkhardt A, Jan?en G. Effective treatment of spasticity using dronabinol in pediatric palliative care. Eur J Paediatr Neurol. 2016 Nov; 20(6):898-903. PMID: 27506815.
      Citations: 13     Fields:    Translation:Humans
    174. Schuster V, Johannes C, Kempkes B, Daschkey S, Bienemann K, Kreth HW, Linka RM, H?nscheid A, Fritz G, Fleckenstein B, Gombert M, Ginzel S, Borkhardt A. Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24. J Clin Immunol. 2016 10; 36(7):684-92. PMID: 27473539.
      Citations: 9     Fields:    Translation:HumansCells
    175. Worst BC, van Tilburg CM, Balasubramanian GP, Fiesel P, Witt R, Freitag A, Boudalil M, Previti C, Wolf S, Schmidt S, Chotewutmontri S, Bewerunge-Hudler M, Schick M, Schlesner M, Hutter B, Taylor L, Borst T, Sutter C, Bartram CR, Milde T, Pfaff E, Kulozik AE, Reinhardt D, Klusmann JH, Fleischhack G, Tippelt S, Westermann F, Fischer M, Bielack SS, Fulda S, Klingebiel T, Koscielniak E, Brors B, von Deimling A, Lichter P, Capper D, Pfister SM, Jones DT, Witt O, von Stackelberg A, Meisel R, Borkhardt A, Dirksen U, J?rgens H, Kramm CM, von Bueren AO, Burkhardt B, W??mann W, Nathrath M, Fr?hwald MC, Schwab M, Tremmel R, Driever PH, Schulte JH, Eggert A. Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur J Cancer. 2016 09; 65:91-101. PMID: 27479119.
      Citations: 138     Fields:    Translation:Humans
    176. Bernhart SH, Richter J, Haake A, Bergmann AK, Brors B, Claviez A, Drexler HG, Eils R, Hoffmann S, Karsch D, Klapper W, Kleinheinz K, Korbel J, Kretzmer H, Kreuz M, Lawerenz C, Loeffler M, Mantovani-Loeffler L, McHardy AC, Rohde M, Rosenstiel P, Schilhabel M, Schlesner M, Scholz I, Stadler PF, Stilgenbauer S, Szczepanowski M, Weniger MA, Siebert R, Hoell JI, ICGC MMML-Seq Project, Hezaveh K, Kloetgen A, Mahapatra KD, Lenze D, Burkhardt B, Haas S, K?ppers R, Leich E, L?pez C, M?ller P, Rosenwald A, Sungalee S, Tr?mper L, Borkhardt A, Hummel M. Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis. Haematologica. 2016 11; 101(11):1380-1389. PMID: 27390358; PMCID: PMC5394868.
      Citations: 32     Fields:    Translation:HumansCells
    177. Simanovsky N, Kfir-Erenfeld S, Assayag-Asherie N, Revel-Vilk S, Yefenof E, Stepensky P, Schipp C, Nabhani S, Bienemann K, Oommen PT, H?nscheid A, Gombert M, Ginzel S, Sch?fer D, Laws HJ, Fleckenstein B, Borkhardt A, Fischer U. Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans. Haematologica. 2016 10; 101(10):e392-e396. PMID: 27365489; PMCID: PMC5046658.
      Citations: 23     Fields:    Translation:Humans
    178. Thiele R, Joosten M, Ginzel S, Blex C, Schmidt D, Gombert M, Chen C, Linka RM, Gr?bner O, Hain A, Hirsch B, Sommerfeld A, Seegebarth A, Gruber U, Maneck C, Zhang L, Stenin K, Dieks H, Sefkow M, M?nk C, Baldus CD, Borkhardt A, Hummel M, K?ster H, Fischer U, Dreger M, Seitz V. A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma. Mol Oncol. 2016 10; 10(8):1232-44. PMID: 27324824; PMCID: PMC5423193.
      Citations: 6     Fields:    Translation:HumansCells
    179. Alawi M, Kutsche K, Vogel M, Velleuer E, Schmidt-Jim?nez LF, Mayatepek E, Borkhardt A, Kort?m F. Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis. Am J Med Genet A. 2016 07; 170(7):1813-9. PMID: 27144914.
      Citations: 9     Fields:    Translation:HumansCells
    180. Schwabe D, Klingebiel T, Bienemann K, Daschkey S, S?rensen J, H?nscheid A, Gombert M, Ginzel S, Borkhardt A. A novel homozygous mutation in UNC13D presenting as Epstein-Barr-virus-associated lymphoproliferative disease at 9?years of age. Leuk Lymphoma. 2016 12; 57(12):2949-2951. PMID: 27123661.
      Citations:    Fields:    Translation:HumansCells
    181. Dasenbrock C, Ravazzani P, Erdmann F, Fedrowitz M, Hamnerius Y, Sanchez-Garcia I, Seger R, Schmiegelow K, Ziegelberger G, Manser M, Schmid CD, Struchen B, Sch?z J, R??sli M, Sch?r P, Bounds PL, Borkhardt A, Cobaleda C, Capstick M, M?ller M, Sch?rmann D, Kuster N. Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium. Bioelectromagnetics. 2016 Apr; 37(3):183-189. PMID: 26991812.
      Citations: 16     Fields:    
    182. Kuhlen M, Hoell J, Balzer S, Borkhardt A, Janssen G. Symptoms and management of pediatric patients with incurable brain tumors in palliative home care. Eur J Paediatr Neurol. 2016 Mar; 20(2):261-269. PMID: 26753538.
      Citations: 8     Fields:    Translation:Humans
    183. Auer F, Ingenhag D, Bhatia S, Borkhardt A, Hauer J, Enczmann J, Cobaleda C, Sanchez-Garcia I. GEMMs addressing Pax5 loss-of-function in childhood pB-ALL. Eur J Med Genet. 2016 Mar; 59(3):166-72. PMID: 26626503.
      Citations: 2     Fields:    Translation:HumansAnimals
    184. Kuhlen M, Schemme J, Merz H, Borkhardt A, Troeger A, H?nscheid A, Mauz-K?rholz C. Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome. Eur J Pediatr. 2016 Apr; 175(4):593-7. PMID: 26526666.
      Citations: 10     Fields:    Translation:Humans
    185. Mulder A, Claas FH, Carrington M, Reusing SB, Manser AR, Enczmann J, Fischer JC, Borkhardt A, Babor F, Uhrberg M. Selective downregulation of HLA-C and HLA-E in childhood acute lymphoblastic leukaemia. Br J Haematol. 2016 08; 174(3):477-80. PMID: 26527563; PMCID: PMC4854806.
      Citations: 11     Fields:    Translation:HumansCells
    186. Kuhlen M, Loizou L, Nabhani S, Fischer U, Stepensky P, Klapper W, Siepermann M, Schuster F, Meisel R, Borkhardt A, H?nscheid A, Schaper J. De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly. Clin Immunol. 2016 Jan; 162:27-30. PMID: 26529633.
      Citations: 15     Fields:    Translation:HumansCells
    187. Kuhlen M, Sabir H, Borkhardt A, H?ll JI, Jan?en G. Experiences in palliative home care of infants with life-limiting conditions. Eur J Pediatr. 2016 Mar; 175(3):321-7. PMID: 26411975.
      Citations: 4     Fields:    Translation:Humans
    188. Hauer J, Auer F, Ginzel S, Thiele R, Bartenhagen C, Dugas M, Gombert M, Rivas Jde L, Borkhardt A, Mart?n-Lorenzo A, Vicente-Due?as C, Gonz?lez-Herrero I, Garc?a-Ram?rez I, Constantinescu SN, Sch?fer D, Blanco O, Mayado A, Orfao A, Alonso-L?pez D, Cobaleda C, Garc?a-Cenador MB, Garc?a-Criado FJ, S?nchez-Garc?a I. Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility. Cancer Discov. 2015 Dec; 5(12):1328-43. PMID: 26408659.
      Citations: 65     Fields:    Translation:AnimalsCells
    189. Doose G, Haake A, Bernhart SH, Wojciech F, Bergmann AK, Claviez A, Karsch D, Klapper W, Kretzmer H, Kreuz M, Lawerenz C, Loeffler M, Ott G, Richter J, Rohde M, Rosenstiel P, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Weniger MA, ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I, L?pez C, Duggimpudi S, Borkhardt A, Burkhardt B, Dimitrova L, Haas S, Hoell JI, Hummel M, Kleo K, K?ppers R, Lenze D, Mantovani-L?ffler L, M?ller P, Rosenwald A, Tr?mper L. MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5261-70. PMID: 26351698; PMCID: PMC4586867.
      Citations: 63     Fields:    Translation:HumansCells
    190. Forster M, Rinaldi A, Risch T, Bornhauser B, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Bartram T, Basso G, Canpolat C, Cario G, Dakaj D, Delorenzi M, Dobay MP, Ellinghaus E, Eugster S, Frismantas V, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hornhardt S, Kachroo P, Kratz CP, Te Kronnie G, Marovca B, Niggli F, Moorman AV, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schrappe M, Schreiber S, Thiele R, Vora A, Zaliova M, Zichner T, Zimmermann M, Lehrach H, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML, Fischer U, Sungalee S, Warnatz HJ, Gombert M, Kratsch C, St?tz AM, Baruchel A, Cav? H, Eckert C, Ginzel S, Hezaveh K, H?ll JI, Husemann P, McHardy AC, Panzer-Gr?mayer R, Sch?fer D, Sch?tte M, Stade B, von der Weid N, Zhang L, Borkhardt A. Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015 Sep; 47(9):1020-1029. PMID: 26214592; PMCID: PMC4603357.
      Citations: 99     Fields:    Translation:HumansAnimals
    191. Troeger A, Koster KL, Laws HJ, Meisel R, Borkhardt A, Oommen PT. Visceral Leishmaniasis as a Possible Reason for Pancytopenia. Front Pediatr. 2015; 3:59. PMID: 26176005; PMCID: PMC4483513.
      Citations: 9     
    192. Miskin H, Revel-Vilk S, Harlev D, Thiele R, Stepensky P, Nabhani S, Ginzel S, Fleckenstein B, H?nscheid A, Oommen PT, Kuhlen M, Laws HJ, Borkhardt A, Fischer U. Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease. Haematologica. 2015 Sep; 100(9):1189-98. PMID: 26113417; PMCID: PMC4800681.
      Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
    193. Bhatia S, Reister S, Mahotka C, Meisel R, Borkhardt A, Grinstein E. Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin. Leukemia. 2015 Nov; 29(11):2208-20. PMID: 26183533.
      Citations: 10     Fields:    Translation:HumansCells
    194. Bradtke J, Teigler-Schlegel A, Harbott J, Thiele R, Hu J, Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, R?ttgers S, Ginzel S, Husemann P, Krell PF, Borkhardt A, Dugas M, Fischer U. Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients. Leuk Res. 2015 Sep; 39(9):990-1001. PMID: 26189108.
      Citations: 20     Fields:    Translation:HumansCells
    195. Laehnemann D, Borkhardt A, McHardy AC. Denoising DNA deep sequencing data-high-throughput sequencing errors and their correction. Brief Bioinform. 2016 Jan; 17(1):154-79. PMID: 26026159; PMCID: PMC4719071.
      Citations: 131     Fields:    Translation:Humans
    196. Kuhlen M, Borkhardt A. Cancer susceptibility syndromes in children in the area of broad clinical use of massive parallel sequencing. Eur J Pediatr. 2015 Aug; 174(8):987-97. PMID: 25982339; PMCID: PMC4516864.
      Citations: 8     Fields:    Translation:Humans
    197. Bienemann K, Borkhardt A, Klapper W, Oschlies I. High incidence of Epstein-Barr virus (EBV)-positive Hodgkin lymphoma and Hodgkin lymphoma-like B-cell lymphoproliferations with EBV latency profile 2 in children with interleukin-2-inducible T-cell kinase deficiency. Histopathology. 2015 Nov; 67(5):607-16. PMID: 25728094.
      Citations: 17     Fields:    Translation:HumansCells
    198. Revel-Vilk S, Rensing-Ehl A, Saleh H, Shaag A, Grimbacher B, Warnatz K, Elpeleg O, Stepensky P, Fischer U, Keller B, Nabhani S, G?mez-D?az L, Gombert M, H?nscheid A, Borkhardt A. Autoimmune lymphoproliferative syndrome-like disease in patients with LRBA mutation. Clin Immunol. 2015 Jul; 159(1):84-92. PMID: 25931386.
      Citations: 46     Fields:    Translation:Humans
    199. Kuhlen M, Balzer S, Friedland C, Borkhardt A, Jan?en G. Critical Situations in Children, Adolescents and Young Adults with Terminal Cancer within the Home Setting. Klin Padiatr. 2015 May; 227(3):137-43. PMID: 25811741.
      Citations: 3     Fields:    Translation:Humans
    200. Duggimpudi S, Larsson E, Nabhani S, Borkhardt A, Hoell JI. The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS. PLoS One. 2015; 10(3):e0119066. PMID: 25751255; PMCID: PMC4353705.
      Citations: 4     Fields:    Translation:HumansCells
    201. Lankisch P, Schiffner J, Ghosh S, Babor F, Borkhardt A, Laws HJ. The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules? J Clin Immunol. 2015 Apr; 35(3):273-9. PMID: 25749910.
      Citations: 18     Fields:    Translation:Humans
    202. Mohammadinejad P, Abolhassani H, Aghamohammadi A, Pourhamdi S, Ghosh S, Sadeghi B, Nasiri Kalmarzi R, Durandy A, Borkhardt A. Class switch recombination process in ataxia telangiectasia patients with elevated serum levels of IgM. J Immunoassay Immunochem. 2015; 36(1):16-26. PMID: 24568663.
      Citations: 7     Fields:    Translation:Humans
    203. Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Lindhofer H, Borkhardt A, Buhmann R, Hess J. Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. Br J Haematol. 2015 Apr; 169(1):90-102. PMID: 25495919.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    204. Hoell JI, Gombert M, Ginzel S, Loth S, Landgraf P, Streiter M, Prokop A, Weiss M, Thiele R, Borkhardt A, K?fer V. Constitutional mismatch repair-deficiency and whole-exome sequencing as the means of the rapid detection of the causative MSH6 defect. Klin Padiatr. 2014 Nov; 226(6-7):357-61. PMID: 25431869.
      Citations: 7     Fields:    Translation:Humans
    205. Stepensky P, Rensing-Ehl A, Gather R, Revel-Vilk S, Fuchs S, Zenke S, Firat E, Pessach VM, Rakhmanov M, Warnatz K, Eibel H, Niedermann G, Elpeleg O, Ehl S, Fischer U, Nabhani S, Beier F, Br?mmendorf TH, Borkhardt A, Keller B. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood. 2015 Jan 29; 125(5):753-61. PMID: 25414442; PMCID: PMC4463807.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    206. Bienemann K, Boztug K, Borkhardt A, Ghosh S. Interleukin-2-inducible T-cell kinase (ITK) deficiency - clinical and molecular aspects. J Clin Immunol. 2014 Nov; 34(8):892-9. PMID: 25339095; PMCID: PMC4220104.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    207. Fleckenstein B, Nabhani S, H?nscheid A, Oommen PT, Schaper J, Kuhlen M, Laws HJ, Borkhardt A, Fischer U. A novel homozygous Fas ligand mutation leads to early protein truncation, abrogation of death receptor and reverse signaling and a severe form of the autoimmune lymphoproliferative syndrome. Clin Immunol. 2014 Dec; 155(2):231-7. PMID: 25451160.
      Citations: 10     Fields:    Translation:HumansCells
    208. Chazara O, Moffett A, Babor F, Manser AR, Fischer JC, Scherenschlich N, Enczmann J, Borkhardt A, Meisel R, Uhrberg M. KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse. Blood. 2014 Oct 02; 124(14):2248-51. PMID: 25163702.
      Citations: 31     Fields:    Translation:HumansCells
    209. Fueller E, Stanulla M, Slany RK, Schaefer D, Fischer U, Krell PF, Borkhardt A. Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia. PLoS One. 2014; 9(8):e104419. PMID: 25137060; PMCID: PMC4138100.
      Citations: 8     Fields:    Translation:HumansCells
    210. Binder V, Bartenhagen C, Okpanyi V, Gombert M, Moehlendick B, Behrens B, Klein HU, Rieder H, Ida Krell PF, Dugas M, Stoecklein NH, Borkhardt A. A new workflow for whole-genome sequencing of single human cells. Hum Mutat. 2014 Oct; 35(10):1260-70. PMID: 25066732.
      Citations: 8     Fields:    Translation:Humans
    211. Serwas NK, Cagdas D, Ban SA, Salzer E, Tezcan I, Sanal O, Boztug K, Bienemann K, Borkhardt A. Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia. Blood. 2014 Jul 24; 124(4):655-7. PMID: 25061172; PMCID: PMC4110665.
      Citations: 20     Fields:    Translation:HumansCells
    212. Rohde M, Richter J, Schlesner M, Betts MJ, Claviez A, Bonn BR, Zimmermann M, Damm-Welk C, Russell RB, Borkhardt A, Eils R, Hoell JI, Szczepanowski M, Oschlies I, Klapper W, Burkhardt B, Siebert R, German ICGC MMML-Seq-Project, NHL-BFM Study Group. Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols. Genes Chromosomes Cancer. 2014 Nov; 53(11):911-6. PMID: 25044415.
      Citations: 29     Fields:    Translation:Humans
    213. Kloetgen A, Borkhardt A, Hoell JI, McHardy AC, M?nch PC. Biochemical and bioinformatic methods for elucidating the role of RNA-protein interactions in posttranscriptional regulation. Brief Funct Genomics. 2015 Mar; 14(2):102-14. PMID: 24951655; PMCID: PMC4471435.
      Citations: 6     Fields:    Translation:Cells
    214. Linka Y, Ginzel S, Borkhardt A, Landgraf P. Identification of TEL-AML1 (ETV6-RUNX1) associated DNA and its impact on mRNA and protein output using ChIP, mRNA expression arrays and SILAC. Genom Data. 2014 Dec; 2:85-8. PMID: 26484077; PMCID: PMC4536161.
      Citations: 2     
    215. Odendahl M, Albrecht J, Tonn T, Seifried E, Stemberger C, Graef P, D?ssinger G, Anderl F, Buchholz VR, Gasteiger G, Schiemann M, Grigoleit GU, Schuster FR, Borkhardt A, Versluys B, Einsele H, Germeroth L, Busch DH, Neuenhahn M. Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy. Blood. 2014 Jul 24; 124(4):628-37. PMID: 24855206.
      Citations: 45     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    216. Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Ryzhova M, Ralser M, Brun S, Bunt J, Kleinheinz K, Erkek S, Weber UD, Bartholomae CC, von Kalle C, Lawerenz C, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Taylor MD, Brors B, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P, Stachurski K, Warnatz HJ, J?ger N, Eils J, Scheurlen W, Felsberg J, Reifenberger G, Borkhardt A, Landgraf P. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 2014 Jun 26; 510(7506):537-41. PMID: 24847876.
      Citations: 213     Fields:    Translation:HumansAnimalsCells
    217. Kuhlen M, Moldovan A, Krull K, Meisel R, Borkhardt A. Osteonecrosis in paediatric patients with acute lymphoblastic leukaemia treated on Co-ALL-07-03 trial: a single centre analysis. Klin Padiatr. 2014 May; 226(3):154-60. PMID: 24710762.
      Citations: 10     Fields:    Translation:Humans
    218. Ghosh S, Schuster FR, Adams O, Babor F, Borkhardt A, Comoli P, Handgretinger R, Lang P, Siepermann M, Meisel R, Laws HJ. Haploidentical stem cell transplantation in DOCK8 deficiency - Successful control of pre-existing severe viremia with a TCRa?/CD19-depleted graft and antiviral treatment. Clin Immunol. 2014 May-Jun; 152(1-2):111-4. PMID: 24667686.
      Citations: 14     Fields:    Translation:HumansCells
    219. Sczyrba A, Dietrich R, Gerlach W, Stoye J, Henrich B, Rumming M, Velleuer E, Gombert M, Rahn S, Borkhardt A, Fischer U. Mycoplasma salivarium as a dominant coloniser of Fanconi anaemia associated oral carcinoma. PLoS One. 2014; 9(3):e92297. PMID: 24642836; PMCID: PMC3958540.
      Citations: 17     Fields:    Translation:HumansCells
    220. Schwarz K, Speckmann C, Ghosh S, H?nscheid A, Eirich K, Schindler D, Sch?nberger S, Borkhardt A, Laws HJ. RAG1 deficiency with a shifting B cell phenotype and chromosomal instability. Clin Immunol. 2014 May-Jun; 152(1-2):65-7. PMID: 24583411.
      Citations: 1     Fields:    Translation:HumansCells
    221. Laws HJ, Adams O, Feiterna-Sperling C, Notheis G, Buchholz B, Borkhardt A, Neubert J, Asang C, Enczmann J. HIV-1 seroreversion in HIV-1-infected children: do genetic determinants play a role? AIDS. 2014 Feb 20; 28(4):543-7. PMID: 24056069.
      Citations: 2     Fields:    Translation:HumansCells
    222. Vicente-Due?as C, Hauer J, Ruiz-Roca L, Ingenhag D, Rodr?guez-Meira A, Auer F, Borkhardt A, S?nchez-Garc?a I. Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy. Semin Cancer Biol. 2015 Jun; 32:3-9. PMID: 24530939.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    223. Hauer J, Borkhardt A, S?nchez-Garc?a I, Cobaleda C. Genetically engineered mouse models of human B-cell precursor leukemias. Cell Cycle. 2014; 13(18):2836-46. PMID: 25486471; PMCID: PMC4613455.
      Citations: 5     Fields:    Translation:HumansAnimals
    224. Izraeli S, Harit M, Weintraub M, Weinstein OY, Lerer I, Stepensky P, Auer F, R?schendorf F, Gombert M, Husemann P, Ginzel S, Borkhardt A, Hauer J. Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A. Leukemia. 2014 May; 28(5):1136-8. PMID: 24287434.
      Citations: 42     Fields:    Translation:Humans
    225. Steger B, Milosevic S, Doessinger G, Reuther S, Liepert A, Braeu M, Schick J, Vogt V, Schuster F, Kroell T, Busch DH, Borkhardt A, Kolb HJ, Tischer J, Buhmann R, Schmetzer H. CD4(+)and CD8(+)T-cell reactions against leukemia-associated- or minor-histocompatibility-antigens in AML-patients after allogeneic SCT. Immunobiology. 2014 Apr; 219(4):247-60. PMID: 24315637.
      Citations: 9     Fields:    Translation:HumansCells
    226. Linka Y, Ginzel S, Novosel A, Gombert M, Kremmer E, Harbott J, Thiele R, Borkhardt A, Landgraf P, Kr?ger M. The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. Blood Cancer J. 2013 Oct 11; 3:e151. PMID: 24121163; PMCID: PMC3816209.
      Citations: 20     Fields:    
    227. Hoell JI, Gombert M, Bartenhagen C, Ginzel S, Husemann P, Reifenberger G, Eggert A, Dugas M, Borkhardt A, Fischer U, Felsberg J, Sch?nberger S. Whole-genome paired-end analysis confirms remarkable genomic stability of atypical teratoid/rhabdoid tumors. Genes Chromosomes Cancer. 2013 Oct; 52(10):983-5. PMID: 23929726.
      Citations: 4     Fields:    Translation:Humans
    228. Lankisch P, Borkhardt A, H?nscheid A, Schaper J, Laws HJ. COL2A1 mutation as a cause of premature osteoarthritis in a 13-year-old child. Joint Bone Spine. 2014 Jan; 81(1):83-5. PMID: 23928235.
      Citations: 4     Fields:    Translation:Humans
    229. Meisel R, Reuther S, Hauer J, Tischer J, Feuchtinger T, Kolb HJ, Borkhardt A, Schuster FR, F?hrer M, Laws HJ. Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia. Br J Haematol. 2013 Sep; 162(6):802-7. PMID: 23829632.
      Citations: 2     Fields:    Translation:HumansCells
    230. Seeger K, Hagedorn N, Mann G, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Escherich G, Sramkova L, Niggli F, Hitzler J, von Stackelberg A, Eckert C, Henze G, Panzer-Gr?mayer R, Schrauder A. Use of allogeneic hematopoietic stem-cell transplantation based on minimal residual disease response improves outcomes for children with relapsed acute lymphoblastic leukemia in the intermediate-risk group. J Clin Oncol. 2013 Jul 20; 31(21):2736-42. PMID: 23775972.
      Citations: 60     Fields:    Translation:Humans
    231. Parvaneh N, Filipovich AH, Borkhardt A. Primary immunodeficiencies predisposed to Epstein-Barr virus-driven haematological diseases. Br J Haematol. 2013 Sep; 162(5):573-86. PMID: 23758097.
      Citations: 43     Fields:    Translation:HumansCells
    232. Reuther S, Fischer U, Keller T, Weber S, Gombert M, Schuster FR, Asang C, Stepensky P, Strahm B, Meisel R, Stoye J, Borkhardt A, Krell PF. Next-generation-sequencing-spectratyping reveals public T-cell receptor repertoires in pediatric very severe aplastic anemia and identifies a ? chain CDR3 sequence associated with hepatitis-induced pathogenesis. Haematologica. 2013 Sep; 98(9):1388-96. PMID: 23716544; PMCID: PMC3762095.
      Citations: 11     Fields:    Translation:HumansCells
    233. Lampert F, Harbott J, Borkhardt A. Cytogenetic aspects of childhood leukemias. Klin Padiatr. 2013 May; 225 Suppl 1:S30-3. PMID: 23700053.
      Citations: 1     Fields:    Translation:Humans
    234. Weiss M, Borkhardt A, Lankisch P, Laws HJ. Agammaglobulinemia and lack of immunization protection in exudative atopic dermatitis. Eur J Pediatr. 2014 Jan; 173(1):117-9. PMID: 23625178.
      Citations: 2     Fields:    Translation:Humans
    235. Stepensky P, Saada A, Cowan M, Tabib A, Fischer U, Berkun Y, Saleh H, Simanovsky N, Kogot-Levin A, Weintraub M, Ganaiem H, Shaag A, Zenvirt S, Borkhardt A, Elpeleg O, Bryant NJ, Mevorach D. The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy. Blood. 2013 Jun 20; 121(25):5078-87. PMID: 23599270.
      Citations: 30     Fields:    Translation:HumansCells
    236. Bartenhagen C, Gombert M, Okpanyi V, Binder V, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A, Chen C, R?ttgers S. Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia. Genes Chromosomes Cancer. 2013 Jun; 52(6):564-79. PMID: 23508829.
      Citations: 12     Fields:    Translation:HumansCells
    237. Lankisch P, Adler H, Borkhardt A. Testing for herpesvirus infection is essential in children with chromosomal-instability syndromes. J Virol. 2013 Mar; 87(6):3616-7. PMID: 23436901; PMCID: PMC3592146.
      Citations: 5     Fields:    Translation:AnimalsCells
    238. Giri A, Bradtke J, Teigler-Schlegel A, Meister G, Borkhardt A, Landgraf P, Daschkey S, R?ttgers S. MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways. PLoS One. 2013; 8(2):e56334. PMID: 23418555; PMCID: PMC3572007.
      Citations: 25     Fields:    Translation:HumansCells
    239. Pfeffer M, Borkhardt A, Niehues T, Adams O, Bolten M, Reuter S, Stannigel H, Laws HJ, Neubert J. Risk adapted transmission prophylaxis to prevent vertical HIV-1 transmission: effectiveness and safety of an abbreviated regimen of postnatal oral zidovudine. BMC Pregnancy Childbirth. 2013 Jan 24; 13:22. PMID: 23347580; PMCID: PMC3568057.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    240. von Stackelberg A, Seeger K, Groeneveld TW, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Escherich G, Eckert C, Henze G. Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed acute lymphoblastic leukaemia - long-term results of trial ALL-REZ BFM P95/96. Eur J Cancer. 2013 Apr; 49(6):1346-55. PMID: 23265714.
      Citations: 30     Fields:    Translation:Humans
    241. Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, MacLeod RA, Pott C, Schreiber S, Loeffler M, Stadler PF, Lichter P, Eils R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R, ICGC MMML-Seq Project, Scholtysik R, M?ller P, Tr?mper L, K?ppers R. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet. 2012 Dec; 44(12):1316-20. PMID: 23143595.
      Citations: 204     Fields:    Translation:HumansCells
    242. Ghosh S, Schuster FR, Fuchs I, Borkhardt A, Meisel R, Laws HJ. Treosulfan-based conditioning in DOCK8 deficiency: complete lympho-hematopoietic reconstitution with minimal toxicity. Clin Immunol. 2012 Dec; 145(3):259-61. PMID: 23128504.
      Citations: 10     Fields:    Translation:Humans
    243. Ingenhag D, Ruckert C, Dugas M, Meisel R, Hauer J, Borkhardt A, Wildenhain S, Degistirici ?. Homeobox protein HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells. J Biol Chem. 2012 Nov 23; 287(48):40703-12. PMID: 23048027; PMCID: PMC3504783.
      Citations: 10     Fields:    Translation:HumansCells
    244. Babor F, Manser A, Borkhardt A, Meisel R, Uhrberg M, Sch?nberg K, Enczmann J. Lack of association between KIR genes and acute lymphoblastic leukemia in children. Blood. 2012 Sep 27; 120(13):2770-2; author reply 2772. PMID: 23019206.
      Citations: 6     Fields:    Translation:Humans
    245. Adams O, Schuster FR, Borkhardt A, Meisel R, Ghosh S. Efficient control of pandemic 2009 H1N1 virus infection with intravenous zanamivir despite the lack of immune function. Transpl Infect Dis. 2012 Dec; 14(6):657-9. PMID: 23013415.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    246. Grund S, Siepermann M, Oommen PT, Kuhlen M, Schuster FR, Laws HJ, Wessalowski R, Bienemann K, Adams O, Borkhardt A, Meisel R, Babor F, Jan?en G. Epidemiology and clinical characteristics of pandemic (H1N1) 2009 influenza infection in pediatric hemato-oncology and hematopoietic stem cell transplantation patients. Transpl Infect Dis. 2012 Dec; 14(6):589-94. PMID: 23013490.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    247. Okpanyi V, Calaminus G, Heikaus S, Leuschner I, Nicholson JC, Stoecklein NH, Schneider DT, Borkhardt A, Sch?nberger S. EPCAM-A novel molecular target for the treatment of pediatric and adult germ cell tumors. Genes Chromosomes Cancer. 2013 Jan; 52(1):24-32. PMID: 22987628.
      Citations: 6     Fields:    Translation:HumansCells
    248. Salzer E, Daschkey S, Choo S, Gombert M, Santos-Valente E, Ginzel S, Schwendinger M, Haas OA, Fritsch G, Pickl WF, Borkhardt A, Boztug K, Bienemann K, Seidel MG, F?rster-Waldl E. Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27. Haematologica. 2013 Mar; 98(3):473-8. PMID: 22801960; PMCID: PMC3659923.
      Citations: 70     Fields:    Translation:HumansCells
    249. Binder V, Steenpass L, Laws HJ, Ruebo J, Borkhardt A. A novel mtDNA large-scale mutation clinically exclusively presenting with refractory anemia: is there a chance to predict disease progression? J Pediatr Hematol Oncol. 2012 May; 34(4):283-92. PMID: 22531495.
      Citations: 1     Fields:    Translation:Humans
    250. Babor F, Schuster F, Mackenzie C, Meisel R, Schaper J, Sabir H, Siepermann M, Wessalowski R, Borkhardt A, Laws HJ, Jan?en G. Invasive aspergillosis in pediatric oncology patients: a rare event with poor prognosis--case analysis to plan better targeted prophylactic or therapeutic measurement. Klin Padiatr. 2012 Apr; 224(3):160-5. PMID: 22504775.
      Citations: 2     Fields:    Translation:Humans
    251. Borkhardt A, Chomienne C, Fibbe WE, Hagenbeek A, Skoda RC, Smand CR, de Wit TD, D?hner H, Fo? R, J?ger U. Raising hematology's European voice: the importance of calling yourself a hematologist. Haematologica. 2012 Apr; 97(4):476-8. PMID: 22492289; PMCID: PMC3347677.
      Citations: 1     Fields:    Translation:Humans
    252. Shaham L, Binder V, Gefen N, Borkhardt A, Izraeli S. MiR-125 in normal and malignant hematopoiesis. Leukemia. 2012 Sep; 26(9):2011-8. PMID: 22456625.
      Citations: 101     Fields:    Translation:HumansAnimals
    253. Reuther S, Schmetzer H, Schuster FR, Krell P, Grabrucker C, Liepert A, Kroell T, Kolb HJ, Borkhardt A, Buhmann R. In vitro-induced response patterns of antileukemic T cells: characterization by spectratyping and immunophenotyping. Clin Exp Med. 2013 Feb; 13(1):29-48. PMID: 22441559.
      Citations: 6     Fields:    Translation:HumansCells
    254. Schuster FR, Binder V, Niehues T, Baldus SE, Seiffert P, Borkhardt A, Meisel R, Ghosh S, Laws HJ. Fatal outcome despite full lympho-hematopoietic reconstitution after allogeneic stem cell transplantation in atypical ataxia telangiectasia. J Clin Immunol. 2012 Jun; 32(3):438-40. PMID: 22354567.
      Citations: 11     Fields:    Translation:Humans
    255. Ruckert C, Hubner B, Eckermann O, Binder V, Bakchoul T, Schuster FR, Merk S, Klein HU, Dugas M, Borkhardt A, Fischer U, F?hrer M. CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL. Haematologica. 2012 Sep; 97(9):1304-11. PMID: 22315490; PMCID: PMC3436230.
      Citations: 6     Fields:    Translation:Humans
    256. Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A, K?hrer K. Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases. Leukemia. 2012 May; 26(5):963-71. PMID: 22289921.
      Citations: 54     Fields:    Translation:HumansCells
    257. Wingen AM, Borkhardt A, Niehues T, Neubert J, Lankisch P, Laws HJ. Association of nephrotic syndrome with immune reconstitution inflammatory syndrome. Pediatr Nephrol. 2012 Apr; 27(4):667-9. PMID: 22203364.
      Citations: 1     Fields:    Translation:HumansCells
    258. Hoell JI, Larsson E, Runge S, Nusbaum JD, Duggimpudi S, Farazi TA, Hafner M, Borkhardt A, Sander C, Tuschl T. RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1428-31. PMID: 22081015; PMCID: PMC3230689.
      Citations: 200     Fields:    Translation:HumansCells
    259. Kuhlen M, Schneider K, Richter U, Borkhardt A, Janssen G. Palliative sedation in 2 children with terminal cancer - an effective treatment of last resort in a home care setting. Klin Padiatr. 2011 Nov; 223(6):374-5. PMID: 22052636.
      Citations:    Fields:    Translation:Humans
    260. Bienemann K, Iouannidou K, Schoenberg K, Krux F, Reuther S, Feyen O, Bienemann K, Schuster F, Uhrberg M, Laws HJ, Borkhardt A. iNKT cell frequency in peripheral blood of Caucasian children and adolescent: the absolute iNKT cell count is stable from birth to adulthood. Scand J Immunol. 2011 Oct; 74(4):406-11. PMID: 21671972.
      Citations: 17     Fields:    Translation:HumansCells
    261. Rettinger E, Willasch AM, Kreyenberg H, Borkhardt A, Holter W, Kremens B, Strahm B, Woessmann W, Mauz-Koerholz C, Gruhn B, Burdach S, Albert MH, Schlegel PG, Klingebiel T, Bader P. Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. Blood. 2011 Nov 17; 118(20):5681-8. PMID: 21948300.
      Citations: 39     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    262. Burkhardt B, Modlich S, Meyer U, Bienemann K, Escherich G, Zimmermann M, Janka-Schaub G, Schrappe M, Reiter A, Borkhardt A, Bienemann K, M?ricke A, Mauz-K?rholz C, K?rholz D. Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): a retrospective survey. Br J Haematol. 2011 Nov; 155(4):468-76. PMID: 21923652.
      Citations: 17     Fields:    Translation:Humans
    263. Neubert J, Niehues T, Adams O, Morali-Karzei N, Borkhardt A, Laws HJ, Ghosh S. Induction maintenance concept for HAART as initial treatment in HIV infected infants. Eur J Med Res. 2011 Jun 21; 16(6):243-8. PMID: 21810557; PMCID: PMC3353398.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    264. Mullighan C, Morillon E, Wang G, Bruneau J, Brousse N, Lelorc'h M, Romana S, Boudil A, Tiedau D, Kracker S, Bushmann FD, Borkhardt A, Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Hauer J. Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia. Blood. 2011 Jul 21; 118(3):544-53. PMID: 21622646; PMCID: PMC3142899.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    265. Mahotka C, Borkhardt A, Grinstein E. Rb and nucleolin antagonize in controlling human CD34 gene expression. Cell Signal. 2011 Aug; 23(8):1358-65. PMID: 21440621.
      Citations: 2     Fields:    Translation:HumansCells
    266. Siepermann M, Koscielniak E, Dantonello T, Klee D, Boos J, Krefeld B, Borkhardt A, Hoehn T, Asea A, Wessalowski R. Oral low-dose chemotherapy: successful treatment of an alveolar rhabdomyosarcoma during pregnancy. Pediatr Blood Cancer. 2012 Jan; 58(1):104-6. PMID: 22076833; PMCID: PMC3138827.
      Citations: 5     Fields:    Translation:Humans
    267. Simon T, Berthold F, Borkhardt A, Kremens B, De Carolis B, Hero B. Treatment and outcomes of patients with relapsed, high-risk neuroblastoma: results of German trials. Pediatr Blood Cancer. 2011 Apr; 56(4):578-83. PMID: 21298742.
      Citations: 60     Fields:    Translation:Humans
    268. Stepensky P, Weintraub M, Yanir A, Revel-Vilk S, Krux F, Huck K, Linka RM, Shaag A, Elpeleg O, Borkhardt A, Resnick IB. IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach. Haematologica. 2011 Mar; 96(3):472-6. PMID: 21109689; PMCID: PMC3046282.
      Citations: 38     Fields:    Translation:HumansCells
    269. Schneider DT, Zahn S, Sievers S, Calaminus G, Nicholson JC, Palmer RD, Leuschner I, Borkhardt A, Okpanyi V, Sch?nberger S. Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors. Pediatr Blood Cancer. 2011 Mar; 56(3):384-91. PMID: 21225915.
      Citations: 8     Fields:    Translation:HumansCells
    270. Sarikaya-Seiwert S, Borkhardt A, Gierga K, Turowski B, Heiroth HJ, Steiger HJ, Stummer W, Eicker S. ALA-induced porphyrin accumulation in medulloblastoma and its use for fluorescence-guided surgery. Cent Eur Neurosurg. 2011 May; 72(2):101-3. PMID: 20931449.
      Citations: 10     Fields:    Translation:Humans
    271. Neubert J, Enczmann J, Krux F, Hower M, Borkhardt A, Laws HJ. Dizygotic twins discordant for HIV-1 despite vertical transmission prophylaxis: was human leukocyte antigen homozygosity of disadvantage to the infected twin? AIDS. 2010 Sep 10; 24(14):2295-6. PMID: 20736685.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    272. Schuster FR, Pierstorff K, Karenfort M, Laws HJ, Borkhardt A, Saleh A, Miese FR. Magnetization transfer imaging provides no evidence of demyelination in methotrexate-induced encephalopathy. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):E110-2. PMID: 20651019; PMCID: PMC8013136.
      Citations: 1     Fields:    Translation:Humans
    273. Burkhardt B, Zimmermann M, Borkhardt A, Kontny U, Klingebiel T, Berthold F, Janka-Schaub G, Klein C, Kabickova E, Klapper W, Attarbaschi A, Schrappe M, Reiter A, Meinhardt A, Berlin-Frankfurt-M?nster group. Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J Clin Oncol. 2010 Jul 01; 28(19):3115-21. PMID: 20516455.
      Citations: 60     Fields:    Translation:HumansCTClinical Trials
    274. Borkhardt A. Where do the leukaemia relapses come from? J Mol Med (Berl). 2010 Mar; 88(3):219-22. PMID: 20135087.
      Citations:    Fields:    Translation:Humans
    275. Neubert J, Laws HJ, Adams O, Niehues T, Korn K, Fleckenstein B, Petri E, Borkhardt A, M?nk C, Kr?mer M. HIV-1 seroreversion following antiretroviral therapy in an HIV-infected child initially presenting with acquired immunodeficiency syndrome. AIDS. 2010 Jan 16; 24(2):327-8. PMID: 20029271.
      Citations: 2     Fields:    Translation:HumansCells
    276. Hertzberg L, Vendramini E, Ganmore I, Cazzaniga G, Schmitz M, Chalker J, Shiloh R, Iacobucci I, Shochat C, Zeligson S, Cario G, Stanulla M, Strehl S, Russell LJ, Harrison CJ, Bornhauser B, Yoda A, Rechavi G, Bercovich D, Borkhardt A, Kempski H, te Kronnie G, Bourquin JP, Domany E, Izraeli S. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood. 2010 Feb 04; 115(5):1006-17. PMID: 19965641.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    277. Plehm S, Unland R, Dirksen U, Borkhardt A, Staege MS, Burdach S, M?ller-Tidow C, Richter GH. Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2. Cell Cycle. 2009 Jul 01; 8(13):1991-6. PMID: 19502792.
      Citations: 38     Fields:    Translation:HumansCells
    278. Balzer S, Richter U, Fritsche-Kansy M, Friedland C, Borkhardt A, Janssen G, Kuhlen M. [Development of a specialised paediatric palliative home care service]. Klin Padiatr. 2009 May-Jun; 221(3):186-92. PMID: 19437372.
      Citations: 3     Fields:    Translation:Humans
    279. Janssen G, Borkhardt A, Laws HJ. Reassessment of treatment modalities for paediatric patients with chronic immune thrombocytopenia. Hamostaseologie. 2009 May; 29(2):171-6. PMID: 19404521.
      Citations:    Fields:    Translation:Humans
    280. Feyen O, Niehues T, Telieps T, Knapp S, Wacker HH, Meindl A, Jumaa H, Borkhardt A, Huck K, R?schendorf F, H?bner N, Laws HJ. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 2009 May; 119(5):1350-8. PMID: 19425169; PMCID: PMC2673872.
      Citations: 112     Fields:    Translation:HumansCells
    281. Bader P, Kreyenberg H, Eckert C, Reising M, Willasch A, Barth A, Borkhardt A, Peters C, Handgretinger R, Sykora KW, Holter W, Kabisch H, Klingebiel T, von Stackelberg A, ALL-REZ BFM Study Group, Henze GH. Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J Clin Oncol. 2009 Jan 20; 27(3):377-84. PMID: 19064980.
      Citations: 128     Fields:    Translation:Humans
    282. Ott H, Gudowius S, Baron JM, Merk HF, Lassay L, Megahed M, Feyen O, Dilloo D, Borkhardt A, Niehues T, Sch?nberger S, W?ller S, Laws HJ. Saving the red baby: successful allogeneic cord blood transplantation in Omenn syndrome. Clin Immunol. 2009 Mar; 130(3):259-63. PMID: 19064334.
      Citations: 1     Fields:    Translation:Humans
    283. Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, Elimelech A, Shochat C, Cazzaniga G, Biondi A, Basso G, Cario G, Schrappe M, Stanulla M, Strehl S, Haas OA, Mann G, Binder V, Borkhardt A, Kempski H, Trka J, Bielorei B, Avigad S, Stark B, Smith O, Dastugue N, Bourquin JP, Tal NB, Green AR, Izraeli S. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet. 2008 Oct 25; 372(9648):1484-92. PMID: 18805579.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    284. Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, Clappier E, Caccavelli L, Delabesse E, Beldjord K, Asnafi V, MacIntyre E, Dal Cortivo L, Radford I, Brousse N, Moshous D, Hauer J, Borkhardt A, Belohradsky BH, Wintergerst U, Velez MC, Leiva L, Sorensen R, Wulffraat N, Bushman FD, Fischer A, Cavazzana-Calvo M, Hacein-Bey-Abina S, Sigaux F, Blanche S. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008 Sep; 118(9):3132-42. PMID: 18688285; PMCID: PMC2496963.
      Citations: 804     Fields:    Translation:HumansCellsCTClinical Trials
    285. Schuster FR, Buhmann R, Reuther S, Hubner B, Grabrucker C, Liepert A, Reibke R, Lichtner P, Yang T, Kroell T, Kolb HJ, Borkhardt A, Schmetzer H. Improved effector function of leukemia-specific T-lymphocyte clones trained with AML-derived dendritic cells. Cancer Genomics Proteomics. 2008 Sep-Oct; 5(5):275-86. PMID: 19129558.
      Citations: 2     Fields:    Translation:HumansCells
    286. Schuetz C, Huck K, Gudowius S, Megahed M, Feyen O, Hubner B, Schneider DT, Manfras B, Pannicke U, Willemze R, Schulz A, Borkhardt A, Friedrich W, Schwarz K, Niehues T, Kn?chel R, G?bel U. An immunodeficiency disease with RAG mutations and granulomas. N Engl J Med. 2008 May 08; 358(19):2030-8. PMID: 18463379.
      Citations: 98     Fields:    Translation:Humans
    287. Hauer J, Tosi S, Schuster FR, Harbott J, Kolb HJ, Borkhardt A. Graft versus leukemia effect after haploidentical HSCT in a MLL-negative infant AML with HLXB9/ETV6 rearrangement. Pediatr Blood Cancer. 2008 Apr; 50(4):921-3. PMID: 17960638.
      Citations: 5     Fields:    Translation:HumansCells
    288. Busch DH, Eppinger E, Kremmer E, Milosevic S, Hennard C, Kuttler C, Ellwart JW, Frankenberger B, Salat C, Bogner C, Borkhardt A, Kolb HJ, Krackhardt AM, Schuster IG, N?ssner E. Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies. Blood. 2007 Oct 15; 110(8):2931-9. PMID: 17626842.
      Citations: 24     Fields:    Translation:HumansCells
    289. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Schliwka J, Fuchs U, Novosel A, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T, Pfeffer S, Fo? R, M?ller RU. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007 Jun 29; 129(7):1401-14. PMID: 17604727; PMCID: PMC2681231.
      Citations: 1956     Fields:    Translation:HumansAnimalsCells
    290. Busch K, Keller T, Fuchs U, Yeh RF, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A, Borkhardt A. Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma. Leukemia. 2007 Aug; 21(8):1739-51. PMID: 17541401.
      Citations: 20     Fields:    Translation:HumansCells
    291. Borkhardt A, Fuchs U. The application of siRNA technology to cancer biology discovery. Adv Cancer Res. 2007; 96:75-102. PMID: 17161677.
      Citations: 6     Fields:    Translation:HumansAnimals
    292. Wossning T, Herzog S, Meixlsperger S, Kulathu Y, Mittler G, Abe A, Fuchs U, Borkhardt A, Jumaa H, K?hler F. Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. J Exp Med. 2006 Dec 25; 203(13):2829-40. PMID: 17130299; PMCID: PMC2118175.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    293. Metzler M, Bruch J, Stachel D, Langer T, Borkhardt A, Harbott J, Rascher W, Holter W. Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement. Leuk Res. 2007 Apr; 31(4):553-7. PMID: 16814860.
      Citations:    Fields:    Translation:HumansCells
    294. Attarbaschi A, Mann G, Steiner M, Strehl S, Schreiberhuber A, Meyer C, Marschalek R, Borkhardt A, Pickl WF, Lion T, Gadner H, Haas OA, Dworzak MN, K?nig M, Schneider B. Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity. Clin Cancer Res. 2006 May 15; 12(10):2988-94. PMID: 16707593.
      Citations: 10     Fields:    Translation:HumansCells
    295. Hess JL, Bittner CB, Zeisig DT, Bach C, Fuchs U, Borkhardt A, Frampton J, Slany RK. c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood. 2006 Jul 01; 108(1):297-304. PMID: 16507773; PMCID: PMC1895838.
      Citations: 87     Fields:    Translation:AnimalsCells
    296. Borkhardt A, Fuchs U, Tuschl T. MicroRNA in chronic lymphocytic leukemia. N Engl J Med. 2006 Feb 02; 354(5):524-5; author reply 524-5. PMID: 16452567.
      Citations: 9     Fields:    Translation:HumansCells
    297. Verschoyle RD, Greaves P, Cai H, Borkhardt A, Broggini M, D'Incalci M, Riccio E, Doppalapudi R, Kapetanovic IM, Steward WP, Gescher AJ. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Cancer Chemother Pharmacol. 2006 Jan; 57(1):1-6. PMID: 16001171.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    298. Wilda M, Perez AV, Bruch J, Woessmann W, Metzler M, Fuchs U, Borkhardt A. Use of MLL/GRAF fusion mRNA for measurement of minimal residual disease during chemotherapy in an infant with acute monoblastic leukemia (AML-M5). Genes Chromosomes Cancer. 2005 Aug; 43(4):424-6. PMID: 15852479.
      Citations: 5     Fields:    Translation:Humans
    299. Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, Friedrich W, Ebell W, Borkhardt A, Bender-Goetze C, F?hrer M. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood. 2005 Sep 15; 106(6):2102-4. PMID: 15933058.
      Citations: 52     Fields:    Translation:HumansCellsCTClinical Trials
    300. Heidenreich O, Borkhardt A. RNA interference as a potential tool in the treatment of leukaemia. Expert Opin Biol Ther. 2004 Dec; 4(12):1921-9. PMID: 15571454.
      Citations: 1     Fields:    Translation:Humans
    301. Kracht T, Schrappe M, Strehl S, Reiter A, Elsner HA, Trka J, Cario G, Viehmann S, Harbott J, Borkhardt A, Metzler M, Langer T, Repp R, Marschalek R, Welte K, Haas OA, Stanulla M. NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms. Haematologica. 2004 Dec; 89(12):1492-7. PMID: 15590400.
      Citations: 8     Fields:    Translation:Humans
    302. Metzler M, Strissel PL, Strick R, Niemeyer C, Roettgers S, Borkhardt A, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Reinhardt D, Creutzig U, Beck JD, Rascher W, Repp R, Langer T. Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2004 Nov; 41(3):291-6. PMID: 15334554.
      Citations: 2     Fields:    Translation:HumansCells
    303. Wilda M, Busch K, Klose I, Keller T, Woessmann W, Kreuder J, Harbott J, Borkhardt A. Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus. Genes Chromosomes Cancer. 2004 Oct; 41(2):178-82. PMID: 15287031.
      Citations: 27     Fields:    Translation:HumansCells
    304. Fuchs U, Damm-Welk C, Borkhardt A. Silencing of disease-related genes by small interfering RNAs. Curr Mol Med. 2004 Aug; 4(5):507-17. PMID: 15267222.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    305. Busch K, Borkhardt A, Reiter A, Harbott J, W?ssmann W. Combined polymerase chain reaction methods to detect c-myc/IgH rearrangement in childhood Burkitt's lymphoma for minimal residual disease analysis. Haematologica. 2004 Jul; 89(7):818-25. PMID: 15257933.
      Citations: 7     Fields:    Translation:HumansCells
    306. Wilda M, Bruch J, Harder L, Rawer D, Reiter A, Borkhardt A, Woessmann W. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children. Leukemia. 2004 Mar; 18(3):584-8. PMID: 14712292.
      Citations: 14     Fields:    Translation:HumansCells
    307. Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer. 2004 Feb; 39(2):167-9. PMID: 14695998.
      Citations: 201     Fields:    Translation:HumansCells
    308. Zeisig BB, Milne T, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK, Garc?a-Cu?llar MP. Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol. 2004 Jan; 24(2):617-28. PMID: 14701735; PMCID: PMC343796.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    309. Woessmann W, Zwanzger D, Borkhardt A. ERK signaling pathway is differentially involved in erythroid differentiation of K562 cells depending on time and the inducing agent. Cell Biol Int. 2004; 28(5):403-10. PMID: 15193284.
      Citations: 15     Fields:    Translation:HumansCells
    310. Callebaut I, Prieur AM, Bodemer C, Lepore L, Derfalvi B, Benjaponpitak S, Vesely R, Sauvain MJ, Oertle S, Allen R, Morgan G, Borkhardt A, Hill C, Gardner-Medwin J, Fischer A, Neven B, Feldmann J, de Saint Basile G. Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood. 2004 Apr 01; 103(7):2809-15. PMID: 14630794.
      Citations: 97     Fields:    Translation:HumansCells
    311. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A. The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. FEBS Lett. 2003 Nov 06; 554(1-2):10-6. PMID: 14596906.
      Citations: 5     Fields:    Translation:HumansCells
    312. Ruf B, Heckmann M, Schroth I, Reiss I, Borkhardt A, Gortner L, H?gens-Penzel M, J?dicke A. Early decompressive craniectomy and duraplasty for refractory intracranial hypertension in children: results of a pilot study. Crit Care. 2003 Dec; 7(6):R133-8. PMID: 14624687; PMCID: PMC374370.
      Citations: 35     Fields:    Translation:Humans
    313. Borkhardt A, Wilda M, Fuchs U, Gortner L, Reiss I. Congenital leukaemia after heavy abuse of permethrin during pregnancy. Arch Dis Child Fetal Neonatal Ed. 2003 Sep; 88(5):F436-7. PMID: 12937054; PMCID: PMC1721623.
      Citations: 7     Fields:    Translation:HumansAnimals
    314. Woessmann W, Damm-Welk C, Fuchs U, Borkhardt A. RNA interference: new mechanisms for targeted treatment? Rev Clin Exp Hematol. 2003 Sep; 7(3):270-91. PMID: 15024970.
      Citations: 6     Fields:    Translation:HumansAnimals
    315. Damm-Welk C, Fuchs U, Borkhardt A, W?ssmann W. Targeting oncogenic fusion genes in leukemias and lymphomas by RNA interference. Semin Cancer Biol. 2003 Aug; 13(4):283-92. PMID: 14563123.
      Citations: 6     Fields:    Translation:HumansAnimals
    316. Bruch J, Wilda M, Teigler-Schlegel A, Harbott J, Borkhardt A, Metzler M. Occurrence of an MLL/LAF4 fusion gene caused by the insertion ins(11;2)(q23;q11.2q11.2) in an infant with acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2003 May; 37(1):106-9. PMID: 12661012.
      Citations: 3     Fields:    Translation:HumansCells
    317. Langer T, Metzler M, Reinhardt D, Viehmann S, Borkhardt A, Reichel M, Stanulla M, Schrappe M, Creutzig U, Leis T, Jacobs U, Harbott J, Rascher W, Repp R, Ritter J, Beck JD. Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Genes Chromosomes Cancer. 2003 Apr; 36(4):393-401. PMID: 12619163.
      Citations: 28     Fields:    Translation:HumansCells
    318. Strehl S, Borkhardt A, Slany R, Fuchs UE, Haas OA, K?nig M. The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). Oncogene. 2003 Jan 09; 22(1):157-60. PMID: 12527918.
      Citations: 13     Fields:    Translation:HumansCells
    319. Ritter U, Damm-Welk C, Fuchs U, Bohle RM, Borkhardt A, Woessmann W. Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL). Oligonucleotides. 2003; 13(5):365-73. PMID: 15000827.
      Citations: 11     Fields:    Translation:HumansCells
    320. Wilda M, Fuchs U, Borkhardt A, W?ssmann W. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene. 2002 Aug 22; 21(37):5716-24. PMID: 12173041.
      Citations: 53     Fields:    Translation:HumansCells
    321. Tuschl T, Borkhardt A. Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Mol Interv. 2002 Jun; 2(3):158-67. PMID: 14993376.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    322. Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O. Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). FEBS Lett. 2002 May 22; 519(1-3):50-8. PMID: 12023017.
      Citations: 13     Fields:    Translation:HumansCells
    323. Borkhardt A, Gossen R, Reiter A, W?ssmann W, G?bel FJ. Acute myeloid leukemia presenting with diabetes insipidus. Eur J Pediatr. 2002 Mar; 161(3):161-2. PMID: 11998915.
      Citations: 2     Fields:    Translation:Humans
    324. Fuchs U, Rehkamp G, Haas OA, Slany R, Konig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8756-61. PMID: 11438682; PMCID: PMC37508.
      Citations: 22     Fields:    Translation:HumansCells
    325. Ferrari T, Weber B, Pils S, Harbott J, Borkhardt A. Absence of point mutations within the AML-1 gene in patients with MDS/AML and loss of chromosome 5q or 7. Ann Hematol. 2001 Feb; 80(2):72-3. PMID: 11261327.
      Citations:    Fields:    Translation:HumansCells
    326. Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9168-73. PMID: 10908648; PMCID: PMC16840.
      Citations: 30     Fields:    Translation:HumansCells
    327. Weber B, Borkhardt A, Stoll-Becker S, Reiss I, Gortner L. Polymorphisms of surfactant protein A genes and the risk of bronchopulmonary dysplasia in preterm infants. Turk J Pediatr. 2000 Jul-Sep; 42(3):181-5. PMID: 11105614.
      Citations: 16     Fields:    Translation:Humans
    328. Viehmann S, Borkhardt A, Lampert F, Harbott J. Multiplex PCR--a rapid screening method for detection of gene rearrangements in childhood acute lymphoblastic leukemia. Ann Hematol. 1999 Apr; 78(4):157-62. PMID: 10348146.
      Citations: 6     Fields:    Translation:HumansCells
    329. Loncarevic IF, Roitzheim B, Ritterbach J, Viehmann S, Borkhardt A, Lampert F, Harbott J. Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion. Genes Chromosomes Cancer. 1999 Mar; 24(3):272-7. PMID: 10451708.
      Citations: 11     Fields:    Translation:Humans
    330. Borkhardt A, Harbott J, Lampert F. Biology and clinical significance of the TEL/AML1 rearrangement. Curr Opin Pediatr. 1999 Feb; 11(1):33-8. PMID: 10084082.
      Citations: 1     Fields:    Translation:Humans
    331. Leis T, Repp R, Borkhardt A, Metzler M, Harbott J, Lampert F, Schl?ger F. A new fingerprint method for sequence analysis of chromosomal translocations at the genomic DNA level. Leukemia. 1998 May; 12(5):758-63. PMID: 9593275.
      Citations: 2     Fields:    Translation:HumansCells
    332. Harbott J, Viehmann S, Borkhardt A, Henze G, Lampert F. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse. Blood. 1997 Dec 15; 90(12):4933-7. PMID: 9389711.
      Citations: 13     Fields:    Translation:HumansCells
    333. Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, Mangioni S, Schrappe M, Riehm H, Lampert F, Basso G, Masera G, Harbott J, Biondi A. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-M?nster Study Group. Blood. 1997 Jul 15; 90(2):571-7. PMID: 9226156.
      Citations: 32     Fields:    Translation:HumansCells
    334. Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). Oncogene. 1997 Jan 16; 14(2):195-202. PMID: 9010221.
      Citations: 59     Fields:    Translation:HumansCells
    335. Schlieben S, Borkhardt A, Reinisch I, Ritterbach J, Janssen JW, Ratei R, Schrappe M, Repp R, Zimmermann M, Kabisch H, Janka-Schaub G, Bartram CR, Ludwig WD, Riehm H, Lampert F, Harbott J. Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92. Leukemia. 1996 Jun; 10(6):957-63. PMID: 8667652.
      Citations: 34     Fields:    Translation:HumansCellsCTClinical Trials
    336. Kreuder J, Borkhardt A, Repp R, Pekrun A, Gottschalk U, Reichmann H, Schachenmayr W, Schlegel K, Lampert F, G?ttsche B. Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase A. N Engl J Med. 1996 Apr 25; 334(17):1100-4. PMID: 8598869.
      Citations: 25     Fields:    Translation:HumansCells
    337. Brettreich S, Repp R, Borkhardt A, Kosmehl H, Altmannsberger HM, Bohle RM. Single somatic ras gene point mutation in soft tissue malignant fibrous histiocytomas. Am J Pathol. 1996 Mar; 148(3):731-8. PMID: 8774129; PMCID: PMC1861737.
      Citations: 5     Fields:    Translation:HumansCells
    338. Borkhardt A, Brettreich S, Borkhardt AK, Repp R, Harbott J, Kreuder J, Lampert F. Low frequency of RAS gene mutations and absence of mutations within the FLR exon of NF1 in patients with therapy-related leukemias. Leukemia. 1995 Oct; 9(10):1790-1. PMID: 7564528.
      Citations:    Fields:    Translation:Humans
    339. Repp R, Borkhardt A, Gossen R, Kreuder J, Hammermann J, Lampert F. Construction of RNA standards for high-resolution automatic product analysis in quantitative competitive RT-PCR. Biotechniques. 1995 Jul; 19(1):84, 86-8, 90. PMID: 7545409.
      Citations: 4     Fields:    Translation:Cells
    340. Borkhardt A, Mitteis M, Brettreich S, Schlieben S, Hammermann J, Repp R, Kreuder J, Buchen U, Lampert F. Rapid synthesis of hybrid RNA molecules associated with leukemia-specific chromosomal translocations. Leukemia. 1995 Apr; 9(4):719-22. PMID: 7723408.
      Citations:    Fields:    Translation:HumansCells
    341. Borkhardt A, Grathwohl J, Repp R, Rheinisch-Becker I, Bohle RM, Lampert F, Bl?tters-Sawatzki R. Secondary acute myeloid leukemia with translocation (4;11) and MLL/AF4 rearrangement in a 15-year-old boy treated for common acute lymphoblastic leukemia 11 years earlier. Ann Hematol. 1995 Jan; 70(1):31-5. PMID: 7827204.
      Citations: 2     Fields:    Translation:HumansCells
    342. Repp R, Borkhardt A, Haupt E, Kreuder J, Brettreich S, Hammermann J, Nishida K, Harbott J, Lampert F. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia. 1995 Jan; 9(1):210-5. PMID: 7845020.
      Citations: 10     Fields:    Translation:HumansCells
    343. Borkhardt A, Repp R, Haupt E, Brettreich S, Buchen U, Gossen R, Lampert F. Molecular analysis of MLL-1/AF4 recombination in infant acute lymphoblastic leukemia. Leukemia. 1994 Apr; 8(4):549-53. PMID: 8152249.
      Citations: 6     Fields:    Translation:HumansCells
    344. Heidemann A, Borkhardt A, Velcovsky HG, Altmannsberger HM, Bohle RM. [Detection of mycobacterial DNA from paraffin-embedded tissue in lung and lymphoid epithelial granulomas]. Verh Dtsch Ges Pathol. 1994; 78:189-94. PMID: 7533984.
      Citations: 2     Fields:    Translation:HumansCells
    345. Borkhardt A, Repp R, Harbott J, Lakomek M, Janssen JW, Schlieben S, Bartram CR, Lampert F. BCR-ABL rearrangement in a child with acute myelogenous leukaemia without a Philadelphia chromosome. Br J Haematol. 1993 Jun; 84(2):341-2. PMID: 8398840.
      Citations:    Fields:    Translation:Humans
    346. Borkhardt A, Repp R, Harbott J, Kreuder J, Lampert F. Quantification of leukaemic cells based on heteroduplex formation of tal-1 gene sequences after PCR coamplification. Br J Haematol. 1993 Jan; 83(1):39-44. PMID: 8435335.
      Citations: 1     Fields:    Translation:HumansCells
    347. Repp R, Csecke A, Kreuder J, Borkhardt A, Willems WR, Lampert F, Gerlich WH, von H?rsten B. Clinical and immunological aspects of hepatitis B virus infection in children receiving multidrug cancer chemotherapy. Arch Virol Suppl. 1993; 8:103-11. PMID: 8260857.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    348. Borkhardt A, Repp R, Harbott J, Keller C, Berner F, Ritterbach J, Lampert F. Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia. Ann Hematol. 1992 Jun; 64(6):305-8. PMID: 1637887.
      Citations:    Fields:    Translation:HumansCells
    349. Repp R, Keller C, Borkhardt A, Csecke A, Schaefer S, Gerlich WH, Lampert F. Detection of a hepatitis B virus variant with a truncated X gene and enhancer II. Arch Virol. 1992; 125(1-4):299-304. PMID: 1642555.
      Citations: 9     Fields:    Translation:HumansCells

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