"DNA Repair" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Descriptor ID |
D004260
|
MeSH Number(s) |
G02.111.222 G05.219
|
Concept/Terms |
Base Excision Repair- Base Excision Repair
- Base Excision Repairs
- Excision Repair, Base
- Repair, Base Excision
- Repairs, Base Excision
|
Below are MeSH descriptors whose meaning is more general than "DNA Repair".
Below are MeSH descriptors whose meaning is more specific than "DNA Repair".
This graph shows the total number of publications written about "DNA Repair" by people in this website by year, and whether "DNA Repair" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2006 | 0 | 1 | 1 |
2007 | 2 | 0 | 2 |
2008 | 0 | 2 | 2 |
2009 | 0 | 3 | 3 |
2011 | 1 | 0 | 1 |
2012 | 1 | 1 | 2 |
2014 | 2 | 3 | 5 |
2015 | 3 | 1 | 4 |
2016 | 6 | 3 | 9 |
2017 | 3 | 2 | 5 |
2018 | 3 | 2 | 5 |
2019 | 2 | 2 | 4 |
2020 | 4 | 3 | 7 |
2021 | 2 | 4 | 6 |
2022 | 1 | 1 | 2 |
2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "DNA Repair" by people in Profiles.
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Mitigating age-related somatic mutation burden. Trends Mol Med. 2023 Jul; 29(7):530-540.
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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nat Struct Mol Biol. 2023 04; 30(4):475-488.
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Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature. 2023 01; 613(7943):365-374.
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Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy. Nat Commun. 2022 02 04; 13(1):701.
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Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasms. Blood Adv. 2021 09 14; 5(17):3373-3376.
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Molecular pathology of rare progeroid diseases. Trends Mol Med. 2021 09; 27(9):907-922.
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The central role of DNA damage in the ageing process. Nature. 2021 04; 592(7856):695-703.
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A DNA repair disorder caused by de novo monoallelic DDB1 variants is associated with a neurodevelopmental syndrome. Am J Hum Genet. 2021 04 01; 108(4):749-756.
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DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population. DNA Repair (Amst). 2021 05; 101:103079.
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Principles of the Molecular and Cellular Mechanisms of Aging. J Invest Dermatol. 2021 04; 141(4S):951-960.