"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Descriptor ID |
D004249
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MeSH Number(s) |
G05.200
|
Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
|
Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2005 | 0 | 1 | 1 |
2006 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2008 | 3 | 0 | 3 |
2009 | 3 | 0 | 3 |
2010 | 1 | 1 | 2 |
2012 | 2 | 0 | 2 |
2013 | 2 | 0 | 2 |
2014 | 3 | 3 | 6 |
2015 | 4 | 2 | 6 |
2016 | 3 | 6 | 9 |
2017 | 4 | 1 | 5 |
2018 | 1 | 4 | 5 |
2019 | 5 | 3 | 8 |
2020 | 3 | 2 | 5 |
2021 | 2 | 4 | 6 |
2022 | 1 | 5 | 6 |
2023 | 0 | 3 | 3 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence. Genet Med. 2023 Jul; 25(7):100836.
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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nat Struct Mol Biol. 2023 04; 30(4):475-488.
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Reply to: Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients". Int J Cancer. 2023 05 01; 152(9):2013.
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The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients. Int J Cancer. 2023 04 01; 152(7):1388-1398.
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Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature. 2023 01; 613(7943):365-374.
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Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice. Int J Mol Sci. 2022 May 17; 23(10).
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The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends Genet. 2022 06; 38(6):598-612.
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Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids. Cells. 2022 02 25; 11(5).
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Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. Nat Commun. 2022 02 08; 13(1):745.
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Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood. Int J Mol Sci. 2021 Oct 26; 22(21).