"Founder Effect" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
Descriptor ID |
D018703
|
MeSH Number(s) |
G05.285
|
Concept/Terms |
Founder Effect- Founder Effect
- Effect, Founder
- Effects, Founder
- Founder Effects
|
Below are MeSH descriptors whose meaning is more general than "Founder Effect".
Below are MeSH descriptors whose meaning is more specific than "Founder Effect".
This graph shows the total number of publications written about "Founder Effect" by people in this website by year, and whether "Founder Effect" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2010 | 0 | 1 | 1 |
2016 | 1 | 1 | 2 |
2020 | 0 | 1 | 1 |
2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Founder Effect" by people in Profiles.
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A 24-generation-old founder mutation impairs splicing of RBBP8 in Pakistani families affected with Jawad syndrome. Clin Genet. 2021 10; 100(4):486-488.
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Identification of a founder mutation in KRT14 associated with Naegeli-Franceschetti-Jadassohn syndrome. Br J Dermatol. 2020 10; 183(4):756-757.
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The Slavic NBN Founder Mutation: A Role for Reproductive Fitness? PLoS One. 2016; 11(12):e0167984.
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A novel homozygous PAM16 mutation in a patient with a milder phenotype and longer survival. Am J Med Genet A. 2016 09; 170(9):2436-9.
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Identification and characterization of 15 novel GALC gene mutations causing Krabbe disease. Hum Mutat. 2010 Dec; 31(12):E1894-914.