"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
1999 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2006 | 0 | 3 | 3 |
2007 | 0 | 1 | 1 |
2008 | 0 | 3 | 3 |
2009 | 0 | 2 | 2 |
2010 | 0 | 4 | 4 |
2011 | 0 | 7 | 7 |
2012 | 0 | 7 | 7 |
2013 | 0 | 11 | 11 |
2014 | 0 | 8 | 8 |
2015 | 0 | 9 | 9 |
2016 | 0 | 10 | 10 |
2017 | 0 | 9 | 9 |
2018 | 0 | 16 | 16 |
2019 | 0 | 9 | 9 |
2020 | 0 | 11 | 11 |
2021 | 0 | 8 | 8 |
2022 | 0 | 3 | 3 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model. Am J Hum Genet. 2022 08 04; 109(8):1436-1457.
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A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn?s disease patients. Mucosal Immunol. 2022 03; 15(3):480-490.
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An instructive role for Interleukin-7 receptor a in the development of human B-cell precursor leukemia. Nat Commun. 2022 02 03; 13(1):659.
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Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation. Nat Cell Biol. 2021 12; 23(12):1224-1239.
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Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation. Proc Natl Acad Sci U S A. 2021 08 03; 118(31).
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Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders. Am J Hum Genet. 2021 08 05; 108(8):1450-1465.
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C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation. J Clin Invest. 2021 06 15; 131(12).
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Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder. Am J Hum Genet. 2021 06 03; 108(6):1069-1082.
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Lymphotoxin ? Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii. Infect Immun. 2021 05 17; 89(6).
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Creld1 regulates myocardial development and function. J Mol Cell Cardiol. 2021 07; 156:45-56.