"Mice, SCID" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Descriptor ID |
D016513
|
MeSH Number(s) |
B01.050.150.900.649.313.992.635.505.500.550.780
|
Concept/Terms |
Mice, SCID- Mice, SCID
- Severe Combined Immunodeficient Mice
- SCID Mice
- Immunodeficient Mice, Severe Combined
- Mouse, SCID
- SCID Mouse
Mouse, SCID-hu- Mouse, SCID-hu
- Mouse, SCID hu
- SCID-hu Mouse
- SCID-hu Mice
- Mice, SCID-hu
- SCID hu Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, SCID".
Below are MeSH descriptors whose meaning is more specific than "Mice, SCID".
This graph shows the total number of publications written about "Mice, SCID" by people in this website by year, and whether "Mice, SCID" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2004 | 0 | 2 | 2 |
2015 | 0 | 2 | 2 |
2017 | 0 | 2 | 2 |
2019 | 0 | 1 | 1 |
2020 | 0 | 3 | 3 |
2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Mice, SCID" by people in Profiles.
-
An instructive role for Interleukin-7 receptor a in the development of human B-cell precursor leukemia. Nat Commun. 2022 02 03; 13(1):659.
-
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy. J Clin Invest. 2020 08 03; 130(8):4266-4281.
-
Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression. Breast Cancer Res. 2020 07 13; 22(1):75.
-
PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth. BMC Mol Cell Biol. 2020 Apr 03; 21(1):24.
-
The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Int J Cancer. 2019 12 15; 145(12):3402-3413.
-
Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells. Sci Rep. 2017 09 21; 7(1):12084.
-
Prominent Oncogenic Roles of EVI1 in Breast Carcinoma. Cancer Res. 2017 04 15; 77(8):2148-2160.
-
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015 Sep; 47(9):1020-1029.
-
Xenotransplantation of cryopreserved human ovarian tissue--a systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment. Fertil Steril. 2015 Jun; 103(6):1557-65.
-
NK cell depletion diminish tumour-specific B cell responses. Immunol Lett. 2004 May 15; 93(2-3):205-10.