"Spliceosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organelles in which the splicing and excision reactions that remove introns from precursor messenger RNA molecules occur. One component of a spliceosome is five small nuclear RNA molecules (U1, U2, U4, U5, U6) that, working in conjunction with proteins, help to fold pieces of RNA into the right shapes and later splice them into the message.
Descriptor ID |
D017381
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MeSH Number(s) |
A11.284.430.106.279.345.850
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spliceosomes".
Below are MeSH descriptors whose meaning is more specific than "Spliceosomes".
This graph shows the total number of publications written about "Spliceosomes" by people in this website by year, and whether "Spliceosomes" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2004 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
2011 | 1 | 1 | 2 |
2012 | 0 | 2 | 2 |
2013 | 1 | 0 | 1 |
2014 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Spliceosomes" by people in Profiles.
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The exon junction complex: structural insights into a faithful companion of mammalian mRNPs. Biochem Soc Trans. 2018 02 19; 46(1):153-161.
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TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. PLoS Genet. 2017 03; 13(3):e1006660.
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CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes. Nucleic Acids Res. 2015 May 19; 43(9):4687-700.
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Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome. Am J Hum Genet. 2014 Dec 04; 95(6):698-707.
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Clinical and mutation data in 12 patients with the clinical diagnosis of Nager syndrome. Hum Genet. 2013 Aug; 132(8):885-98.
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Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex. Am J Hum Genet. 2013 Jan 10; 92(1):81-7.
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Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly. Am J Hum Genet. 2012 Feb 10; 90(2):369-77.
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Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I. Science. 2011 Apr 08; 332(6026):238-40.
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Assembly, disassembly and recycling: the dynamics of exon junction complexes. RNA Biol. 2011 Jan-Feb; 8(1):24-9.
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Evolution of spliceosomal introns following endosymbiotic gene transfer. BMC Evol Biol. 2010 Feb 23; 10:57.