"Nonsense Mediated mRNA Decay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.
| Descriptor ID |
D059365
|
| MeSH Number(s) |
G02.111.760.112 G02.111.780.500 G03.839.112 G05.308.700.112
|
| Concept/Terms |
Nonsense Mediated mRNA Decay- Nonsense Mediated mRNA Decay
- Nonsense-Mediated mRNA Decay
- Decay, Nonsense-Mediated mRNA
- mRNA Decay, Nonsense-Mediated
|
Below are MeSH descriptors whose meaning is more general than "Nonsense Mediated mRNA Decay".
Below are MeSH descriptors whose meaning is more specific than "Nonsense Mediated mRNA Decay".
This graph shows the total number of publications written about "Nonsense Mediated mRNA Decay" by people in this website by year, and whether "Nonsense Mediated mRNA Decay" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 3 | 0 | 3 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 0 | 3 |
| 2017 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nonsense Mediated mRNA Decay" by people in Profiles.
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Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay. EMBO J. 2022 05 16; 41(10):e109191.
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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity. Nat Commun. 2021 06 25; 12(1):3965.
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CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex. Nucleic Acids Res. 2020 09 04; 48(15):8626-8644.
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Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells. Sci Rep. 2017 09 06; 7(1):10616.
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Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. RNA. 2017 08; 23(8):1224-1236.
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Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences. Nat Commun. 2016 12 05; 7:13691.
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Harnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay. Sci Rep. 2016 11 22; 6:37311.
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Physiological and pathophysiological role of nonsense-mediated mRNA decay. Pflugers Arch. 2016 06; 468(6):1013-28.
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Mechanism, factors, and physiological role of nonsense-mediated mRNA decay. Cell Mol Life Sci. 2015 Dec; 72(23):4523-44.
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3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons. Cell Rep. 2014 Oct 23; 9(2):555-68.
MeSH information
