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Niels Gehring

Prof.
University of Köln
Department of Biology, Institute for Genetics
Zülpicher Straße 47a, 50674 Köln, Germany
Köln 50674
+49 221 4703873
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, Trifunovic A, Langer T, Gehring NH, Becker T, Riemer J. A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. J Cell Biol. 2023 07 03; 222(7). PMID: 37159021; PMCID: PMC10174193.
      Citations: 1     Fields:    Translation:Cells
    2. Efstathiou S, Ottens F, Sch?tter LS, Ravanelli S, Charmpilas N, Gutschmidt A, Le Pen J, Gehring NH, Miska EA, Bou?as J, Hoppe T. ER-associated RNA silencing promotes ER quality control. Nat Cell Biol. 2022 Dec; 24(12):1714-1725. PMID: 36471127.
      Citations: 2     Fields:    Translation:Cells
    3. Schlautmann LP, Lackmann JW, Dieterich C, Boehm V, Gehring NH, Altm?ller J. Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance. Nucleic Acids Res. 2022 06 10; 50(10):5899-5918. PMID: 35640609; PMCID: PMC9178013.
      Citations: 2     Fields:    Translation:HumansCells
    4. Wallmeroth D, Lackmann JW, Kueckelmann S, Boehm V, Gehring NH, Altm?ller J, Dieterich C. Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay. EMBO J. 2022 05 16; 41(10):e109191. PMID: 35451084; PMCID: PMC9108619.
      Citations: 11     Fields:    Translation:HumansCells
    5. Boehm V, Kueckelmann S, Gerbracht JV, Kallabis S, Britto-Borges T, Dieterich C, Gehring NH, Altm?ller J, Kr?ger M. SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity. Nat Commun. 2021 06 25; 12(1):3965. PMID: 34172724; PMCID: PMC8233366.
      Citations: 31     Fields:    Translation:HumansCells
    6. Wang Q, Boenigk S, Boehm V, Gehring NH, Altmueller J, Dieterich C. Single cell transcriptome sequencing on the Nanopore platform with ScNapBar. RNA. 2021 Apr 27. PMID: 33906975; PMCID: PMC8208055.
      Citations: 8     Fields:    
    7. Erkelenz S, Stankovic D, Mundorf J, Bresser T, Claudius AK, Boehm V, Gehring NH, Uhlirova M. Ecd promotes U5 snRNP maturation and Prp8 stability. Nucleic Acids Res. 2021 02 22; 49(3):1688-1707. PMID: 33444449; PMCID: PMC7897482.
      Citations: 8     Fields:    Translation:AnimalsCells
    8. Gehring NH, Roignant JY. Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation. Trends Genet. 2021 04; 37(4):355-372. PMID: 33203572.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    9. Gerbracht JV, Boehm V, Britto-Borges T, Kallabis S, Wiederstein JL, Ciriello S, Aschemeier DU, Frese CK, Dieterich C, Gehring NH, Kr?ger M, Altm?ller J. CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex. Nucleic Acids Res. 2020 09 04; 48(15):8626-8644. PMID: 32621609; PMCID: PMC7470949.
      Citations: 20     Fields:    Translation:HumansCells
    10. Schlautmann LP, Gehring NH. A Day in the Life of the Exon Junction Complex. Biomolecules. 2020 06 05; 10(6). PMID: 32517083; PMCID: PMC7355637.
      Citations: 36     Fields:    Translation:HumansCells
    11. Ulrich HD, Sriramachandran AM, Meyer-Teschendorf K, Pabst S, Gehring NH, Hofmann K, Praefcke GJK, Dohmen RJ. Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain. Nat Commun. 2019 08 15; 10(1):3678. PMID: 31417085; PMCID: PMC6695498.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    12. Saez I, Gerbracht JV, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel MS, Dieterich C, Gehring NH, Vilchez D. The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett. 2020 01; 594(1):175-188. PMID: 31365120.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    13. Voigt F, Gerbracht JV, Boehm V, Horvathova I, Eglinger J, Chao JA, Gehring NH. Detection and quantification of RNA decay intermediates using XRN1-resistant reporter transcripts. Nat Protoc. 2019 05; 14(5):1603-1633. PMID: 31019309.
      Citations: 11     Fields:    Translation:Cells
    14. Boehm V, Britto-Borges T, Steckelberg AL, Singh KK, Gerbracht JV, Gueney E, Blazquez L, Dieterich C, Gehring NH, Altm?ller J. Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity. Mol Cell. 2018 11 01; 72(3):482-495.e7. PMID: 30388410.
      Citations: 33     Fields:    Translation:HumansCells
    15. Gerbracht JV, Gehring NH. The exon junction complex: structural insights into a faithful companion of mammalian mRNPs. Biochem Soc Trans. 2018 02 19; 46(1):153-161. PMID: 29351963.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Gerbracht JV, Boehm V, Gehring NH. Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells. Sci Rep. 2017 09 06; 7(1):10616. PMID: 28878343; PMCID: PMC5587671.
      Citations: 13     Fields:    Translation:HumansCells
    17. Ottens F, Boehm V, Sibley CR, Ule J, Gehring NH. Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. RNA. 2017 08; 23(8):1224-1236. PMID: 28461625; PMCID: PMC5513067.
      Citations: 18     Fields:    Translation:HumansCells
    18. Gehring NH, Wahle E, Fischer U. Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation. Trends Biochem Sci. 2017 05; 42(5):369-382. PMID: 28268044.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    19. Boehm V, Gerbracht JV, Marx MC, Gehring NH. Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences. Nat Commun. 2016 12 05; 7:13691. PMID: 27917860; PMCID: PMC5150221.
      Citations: 17     Fields:    Translation:HumansCells
    20. Fatscher T, Gehring NH. Harnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay. Sci Rep. 2016 11 22; 6:37311. PMID: 27874031; PMCID: PMC5118804.
      Citations: 4     Fields:    Translation:HumansCells
    21. Boehm V, Gehring NH. Exon Junction Complexes: Supervising the Gene Expression Assembly Line. Trends Genet. 2016 11; 32(11):724-735. PMID: 27667727.
      Citations: 62     Fields:    Translation:Cells
    22. Ottens F, Gehring NH. Physiological and pathophysiological role of nonsense-mediated mRNA decay. Pflugers Arch. 2016 06; 468(6):1013-28. PMID: 27138169.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    23. Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NH. A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acids Res. 2016 Mar 18; 44(5):2348-61. PMID: 26773052; PMCID: PMC4797287.
      Citations: 37     Fields:    Translation:HumansCells
    24. Soto-Rifo R, Kulozik AE, Gehring NH, Ajamian L, Abel K, Rao S, Vyboh K, Garc?a-de-Gracia F, Mouland AJ. HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA. Biomolecules. 2015 Oct 20; 5(4):2808-39. PMID: 26492277; PMCID: PMC4693258.
      Citations: 35     Fields:    Translation:HumansCells
    25. Fatscher T, Boehm V, Gehring NH. Mechanism, factors, and physiological role of nonsense-mediated mRNA decay. Cell Mol Life Sci. 2015 Dec; 72(23):4523-44. PMID: 26283621.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    26. Linder B, Fischer U, Gehring NH. mRNA metabolism and neuronal disease. FEBS Lett. 2015 Jun 22; 589(14):1598-606. PMID: 25957814.
      Citations: 13     Fields:    Translation:HumansCells
    27. Steckelberg AL, Altmueller J, Gehring NH, Dieterich C. CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes. Nucleic Acids Res. 2015 May 19; 43(9):4687-700. PMID: 25870412; PMCID: PMC4482076.
      Citations: 15     Fields:    Translation:HumansCells
    28. Stockklausner C, Klotter AC, Dickemann N, Kuhlee IN, Duffert CM, Kerber C, Gehring NH, Kulozik AE. The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis. Blood. 2015 Feb 12; 125(7):1159-69. PMID: 25538044.
      Citations: 11     Fields:    Translation:HumansCells
    29. Boehm V, Haberman N, Ottens F, Ule J, Gehring NH. 3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons. Cell Rep. 2014 Oct 23; 9(2):555-68. PMID: 25310981.
      Citations: 52     Fields:    Translation:HumansCells
    30. Fatscher T, Boehm V, Weiche B, Gehring NH. The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay. RNA. 2014 Oct; 20(10):1579-92. PMID: 25147240; PMCID: PMC4174440.
      Citations: 45     Fields:    Translation:HumansCells
    31. Peche VS, Steckelberg AL, Gehring NH, Noegel AA, Burgute BD, Gl?ckner G, Ga?en B. NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins. Nucleic Acids Res. 2014 Mar; 42(5):3177-93. PMID: 24353314; PMCID: PMC3950704.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    32. Clerici M, Boehm V, Gehring NH, Schaffitzel C, Cusack S, Deniaud A. Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2. Nucleic Acids Res. 2014 Feb; 42(4):2673-86. PMID: 24271394; PMCID: PMC3936715.
      Citations: 28     Fields:    Translation:HumansCells
    33. Steckelberg AL, Gehring NH. Studying the composition of mRNPs in vitro using splicing-competent cell extracts. Methods. 2014 Feb; 65(3):342-9. PMID: 24021717.
      Citations: 3     Fields:    Translation:HumansCells
    34. Singh KK, Wachsmuth L, Kulozik AE, Gehring NH. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. RNA Biol. 2013 Aug; 10(8):1291-8. PMID: 23917022; PMCID: PMC3817150.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    35. Giannandrea M, Guarnieri FC, Gehring NH, Monzani E, Benfenati F, Kulozik AE, Valtorta F. Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356? mutation in synapsin I. PLoS One. 2013; 8(6):e67724. PMID: 23818987; PMCID: PMC3688603.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    36. Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH. CWC22 connects pre-mRNA splicing and exon junction complex assembly. Cell Rep. 2012 Sep 27; 2(3):454-61. PMID: 22959432.
      Citations: 62     Fields:    Translation:HumansCells
    37. Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE. Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon. RNA. 2011 May; 17(5):843-54. PMID: 21389146; PMCID: PMC3078734.
      Citations: 71     Fields:    Translation:HumansCells
    38. Gehring NH, Bono F. Assembly, disassembly and recycling: the dynamics of exon junction complexes. RNA Biol. 2011 Jan-Feb; 8(1):24-9. PMID: 21289489; PMCID: PMC3127076.
      Citations: 41     Fields:    Translation:HumansCells
    39. Dang Y, Low WK, Xu J, Gehring NH, Dietz HC, Romo D, Liu JO. Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem. 2009 Aug 28; 284(35):23613-21. PMID: 19570977; PMCID: PMC2749136.
      Citations: 38     Fields:    Translation:HumansCells
    40. Clerici M, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S, Mour?o A. Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J. 2009 Aug 05; 28(15):2293-306. PMID: 19556969; PMCID: PMC2726699.
      Citations: 89     Fields:    Translation:Cells
    41. Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE. The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. PLoS Biol. 2009 May 26; 7(5):e1000120. PMID: 19478851; PMCID: PMC2682485.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    42. Gehring NH, Lamprinaki S, Kulozik AE, Hentze MW. Disassembly of exon junction complexes by PYM. Cell. 2009 May 01; 137(3):536-48. PMID: 19410547.
      Citations: 111     Fields:    Translation:HumansCells
    43. Handoko L, Laggerbauer B, Jablonka S, Chari A, Alzheimer M, Gehring N, Sickmann A, von Au K, Schuelke M, Fischer U, Guenther UP, Ohmer J, Pl?ttner O. IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1). Hum Mol Genet. 2009 Apr 01; 18(7):1288-300. PMID: 19158098.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    44. Abrahamyan L, Milev M, Ivanov PV, Kulozik AE, Gehring NH, Mouland AJ, Ajamian L. Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation. RNA. 2008 May; 14(5):914-27. PMID: 18369187; PMCID: PMC2327365.
      Citations: 62     Fields:    Translation:HumansCells
    45. Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE. Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J. 2008 Mar 05; 27(5):736-47. PMID: 18256688; PMCID: PMC2265754.
      Citations: 187     Fields:    Translation:HumansCells
    46. Gehring NH, Hentze MW, Kulozik AE. Tethering assays to investigate nonsense-mediated mRNA decay activating proteins. Methods Enzymol. 2008; 448:467-82. PMID: 19111190.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    47. Viegas MH, Gehring NH, Breit S, Hentze MW, Kulozik AE. The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Nucleic Acids Res. 2007; 35(13):4542-51. PMID: 17586820; PMCID: PMC1935013.
      Citations: 75     Fields:    Translation:HumansCells
    48. Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, Hentze MW, Kulozik AE. Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J. 2007 Jun 06; 26(11):2658-69. PMID: 17464285; PMCID: PMC1888663.
      Citations: 56     Fields:    Translation:HumansCells
    49. Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay. Biochem Biophys Res Commun. 2006 Oct 13; 349(1):186-91. PMID: 16934750.
      Citations: 32     Fields:    Translation:HumansCells
    50. Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW. Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay. EMBO Rep. 2006 Jul; 7(7):722-6. PMID: 16799467; PMCID: PMC1500827.
      Citations: 13     Fields:    Translation:HumansCells
    51. Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH. The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD). Nucleic Acids Res. 2006; 34(8):2355-63. PMID: 16679454; PMCID: PMC1458284.
      Citations: 23     Fields:    Translation:HumansCells
    52. Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA. 2006 Jun; 12(6):1015-22. PMID: 16601204; PMCID: PMC1464862.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    53. Danckwardt S, Hartmann K, Gehring NH, Hentze MW, Kulozik AE. 3' end processing of the prothrombin mRNA in thrombophilia. Acta Haematol. 2006; 115(3-4):192-7. PMID: 16549895.
      Citations: 7     Fields:    Translation:HumansCells
    54. Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell. 2005 Oct 07; 20(1):65-75. PMID: 16209946.
      Citations: 177     Fields:    Translation:HumansAnimalsCells
    55. Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Blood. 2004 Jul 15; 104(2):428-35. PMID: 15059842.
      Citations: 28     Fields:    Translation:HumansCells
    56. Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol. 2004; 5(4):218. PMID: 15059251; PMCID: PMC395777.
      Citations: 35     Fields:    Translation:HumansAnimals
    57. Monshausen M, Gehring NH, Kosik KS. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Neuromolecular Med. 2004; 6(2-3):127-44. PMID: 15970630.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    58. Baron-Benhamou J, Gehring NH, Kulozik AE, Hentze MW. Using the lambdaN peptide to tether proteins to RNAs. Methods Mol Biol. 2004; 257:135-54. PMID: 14770003.
      Citations: 57     Fields:    Translation:HumansCells
    59. Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE. Y14 and hUpf3b form an NMD-activating complex. Mol Cell. 2003 Apr; 11(4):939-49. PMID: 12718880.
      Citations: 143     Fields:    Translation:HumansCells
    60. Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE, Gehring NH. Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia. Nat Genet. 2001 Aug; 28(4):389-92. PMID: 11443298.
      Citations: 75     Fields:    Translation:HumansCells
    61. Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM, Lewitzky M. The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif. Oncogene. 2001 Mar 01; 20(9):1052-62. PMID: 11314042.
      Citations: 38     Fields:    Translation:HumansCells
    62. Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE, Neu-Yilik G. Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs. EMBO J. 2001 Feb 01; 20(3):532-40. PMID: 11157759; PMCID: PMC133467.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    63. Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W, Schaeper U. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol. 2000 Jun 26; 149(7):1419-32. PMID: 10871282; PMCID: PMC2175135.
      Citations: 118     Fields:    Translation:Cells
    64. Gehring NH, Hentze MW, Pantopoulos K. Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. J Biol Chem. 1999 Mar 05; 274(10):6219-25. PMID: 10037708.
      Citations: 11     Fields:    Translation:HumansAnimalsCells

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