"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
| Descriptor ID |
D053823
|
| MeSH Number(s) |
D12.644.276.671 D12.776.467.671 D23.529.671
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".
Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".
This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 2 | 1 | 3 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.
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The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nat Commun. 2022 07 13; 13(1):4061.
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An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma. Neuro Oncol. 2021 04 12; 23(4):586-598.
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Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma. J Clin Oncol. 2020 01 01; 38(1):43-50.
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Further evidence for complex inheritance of holoprosencephaly: Lessons learned from pre- and postnatal diagnostic testing in Germany. Am J Med Genet C Semin Med Genet. 2018 06; 178(2):198-205.
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Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. Dev Cell. 2018 03 26; 44(6):709-724.e6.
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Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling. Eur J Hum Genet. 2018 02; 26(2):197-209.
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Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh. Mol Neurobiol. 2017 08; 54(6):4414-4420.
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Digit evolution in gymnophthalmid lizards. Int J Dev Biol. 2014; 58(10-12):895-908.
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Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis. Am J Hum Genet. 2011 Jan 07; 88(1):70-5.
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A specific mutation in the distant sonic hedgehog (SHH) cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZRS duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb. Hum Mutat. 2010 Jan; 31(1):81-9.
MeSH information
