"Toll-Like Receptor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
Descriptor ID |
D051197
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MeSH Number(s) |
D12.776.543.750.705.910.500.400
|
Concept/Terms |
Toll-Like Receptor 4- Toll-Like Receptor 4
- Toll Like Receptor 4
- Toll-4 Receptor
- Toll 4 Receptor
- TLR4 Receptor
- Receptor, TLR4
|
Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 4".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 4".
This graph shows the total number of publications written about "Toll-Like Receptor 4" by people in this website by year, and whether "Toll-Like Receptor 4" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
2011 | 0 | 1 | 1 |
2013 | 1 | 1 | 2 |
2014 | 1 | 0 | 1 |
2016 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
2018 | 0 | 1 | 1 |
2019 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Toll-Like Receptor 4" by people in Profiles.
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The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway. Front Immunol. 2022; 13:856230.
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Autophagy, TERT, and mitochondrial dysfunction in hyperoxia. Am J Physiol Heart Circ Physiol. 2021 11 01; 321(5):H985-H1003.
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Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis. Gut. 2020 03; 69(3):551-563.
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Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest. 2018 05 01; 128(5):1852-1866.
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S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol. 2017 06; 18(6):622-632.
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Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut. 2017 03; 66(3):507-518.
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Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8. J Immunol. 2015 Jan 15; 194(2):575-83.
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High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol. 2014 Feb; 15(2):152-60.
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TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue. Seizure. 2013 Oct; 22(8):675-8.
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Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J. 2012 Jan 04; 31(1):201-13.