"Proto-Oncogene Proteins c-kit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
| Descriptor ID |
D019009
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.050 D12.776.543.750.630.124 D12.776.543.750.705.852.150.100 D12.776.543.750.750.400.200.170 D12.776.624.664.700.183
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| Concept/Terms |
Proto-Oncogene Proteins c-kit- Proto-Oncogene Proteins c-kit
- Proto Oncogene Proteins c kit
- c-kit, Proto-Oncogene Proteins
- Stem Cell Factor Receptor
- SCF Receptor
- p145 c-kit
- c-kit, p145
- p145 c kit
- p145(c-kit)
- p145c-kit
- p145c kit
- CD117 Antigen
- Antigens, CD117
- CD117 Antigens
- Proto-Oncogene Protein c-kit
- Proto Oncogene Protein c kit
- c-kit, Proto-Oncogene Protein
- c-kit Protein
- c kit Protein
- kit Proto-Oncogene Protein
- Proto-Oncogene Protein, kit
- kit Proto Oncogene Protein
- Receptor, Stem Cell Factor
- Proto-Oncogene Protein kit
- Proto Oncogene Protein kit
- c-kit Receptor
- c kit Receptor
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-kit".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-kit".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-kit" by people in this website by year, and whether "Proto-Oncogene Proteins c-kit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2019 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-kit" by people in Profiles.
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Transformation of primary murine peritoneal mast cells by constitutive KIT activation is accompanied by loss of Cdkn2a/Arf expression. Front Immunol. 2023; 14:1154416.
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KIT D816V Mast Cells Derived from Induced Pluripotent Stem Cells Recapitulate Systemic Mastocytosis Transcriptional Profile. Int J Mol Sci. 2023 Mar 09; 24(6).
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Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases. Blood. 2019 09 26; 134(13):1046-1058.
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The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. J Immunol. 2017 10 15; 199(8):2948-2957.
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MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing. Oncotarget. 2017 Jun 06; 8(23):37225-37238.
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A transit-amplifying population underpins the efficient regenerative capacity of the testis. J Exp Med. 2017 06 05; 214(6):1631-1641.
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Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014 Feb 10; 211(2):209-15.
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The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KitD816V systemic mastocytosis. Immunol Res. 2013 May; 56(1):155-62.
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Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Res. 2012 Jun 01; 72(11):2757-67.
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Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia. Blood. 2011 Jul 21; 118(3):544-53.
MeSH information
