"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
|
MeSH Number(s) |
E05.393.620.500
|
Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
|
Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 2 | 1 | 3 |
1995 | 4 | 2 | 6 |
1996 | 1 | 4 | 5 |
1997 | 2 | 2 | 4 |
1998 | 2 | 6 | 8 |
1999 | 3 | 2 | 5 |
2000 | 0 | 3 | 3 |
2001 | 0 | 1 | 1 |
2003 | 2 | 3 | 5 |
2004 | 1 | 3 | 4 |
2005 | 0 | 5 | 5 |
2006 | 0 | 2 | 2 |
2007 | 1 | 1 | 2 |
2008 | 0 | 2 | 2 |
2009 | 1 | 3 | 4 |
2010 | 1 | 2 | 3 |
2011 | 1 | 4 | 5 |
2012 | 0 | 4 | 4 |
2013 | 0 | 2 | 2 |
2014 | 1 | 4 | 5 |
2015 | 0 | 3 | 3 |
2016 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
2018 | 2 | 1 | 3 |
2019 | 0 | 2 | 2 |
2020 | 0 | 2 | 2 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany. Nat Commun. 2020 11 17; 11(1):5829.
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Evidence for signatures of ancient microbial life in paleosols. Sci Rep. 2020 10 08; 10(1):16830.
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Quasi-Mendelian paternal inheritance of mitochondrial DNA: A notorious artifact, or anticipated behavior? Proc Natl Acad Sci U S A. 2019 07 23; 116(30):14797-14798.
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Unsupported claim of significant discrimination between monozygotic twins from multiple pairs based on three age-related DNA methylation markers. Forensic Sci Int Genet. 2019 03; 39:e1-e2.
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Systematic evaluation of error rates and causes in short samples in next-generation sequencing. Sci Rep. 2018 Jul 19; 8(1):10950.
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Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening. Blood. 2018 02 15; 131(7):821-826.
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Locus-Specific DNA Methylation Analysis by Targeted Deep Bisulfite Sequencing. Methods Mol Biol. 2018; 1767:351-366.
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First Insights into the Diverse Human Archaeome: Specific Detection of Archaea in the Gastrointestinal Tract, Lung, and Nose and on Skin. mBio. 2017 11 14; 8(6).
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Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. Immunity. 2016 11 15; 45(5):1148-1161.
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Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans. Nat Commun. 2015 Sep 01; 6:8086.