"Progeria" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
| Descriptor ID |
D011371
|
| MeSH Number(s) |
C16.320.565.753 C18.452.648.753
|
| Concept/Terms |
Progeria- Progeria
- Hutchinson-Gilford Syndrome
- Hutchinson Gilford Syndrome
- Hutchinson Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndromes
- Progeria Syndrome, Hutchinson-Gilford
- Progeria Syndromes, Hutchinson-Gilford
|
Below are MeSH descriptors whose meaning is more general than "Progeria".
Below are MeSH descriptors whose meaning is more specific than "Progeria".
This graph shows the total number of publications written about "Progeria" by people in this website by year, and whether "Progeria" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 2 | 3 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Progeria" by people in Profiles.
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Biallelic variants in YRDC cause a developmental disorder with progeroid features. Hum Genet. 2021 Dec; 140(12):1679-1693.
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Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations. Hum Genet. 2018 Dec; 137(11-12):921-939.
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De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. Am J Hum Genet. 2017 Nov 02; 101(5):833-843.
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Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet. 2014 Nov; 46(11):1239-44.
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Transcriptional profiling reveals progeroid Ercc1(-/?) mice as a model system for glomerular aging. BMC Genomics. 2013 Aug 16; 14:559.
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Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol. 2009 May; 11(5):604-15.
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Sealing the gap between nuclear DNA damage and longevity. Mol Cell Endocrinol. 2009 Feb 05; 299(1):112-7.
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Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet. 2008 Aug 15; 4(8):e1000161.
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Age to survive: DNA damage and aging. Trends Genet. 2008 Feb; 24(2):77-85.
MeSH information
