"Checkpoint Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.
Descriptor ID |
D064447
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MeSH Number(s) |
D08.811.913.696.620.682.700.145
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Concept/Terms |
Checkpoint Kinase 2- Checkpoint Kinase 2
- Kinase 2, Checkpoint
- Chk2 Protein Kinase
- Kinase, Chk2 Protein
- Protein Kinase, Chk2
- Checkpoint-Like Protein CHK2
- CHK2, Checkpoint-Like Protein
- Checkpoint Like Protein CHK2
- Protein CHK2, Checkpoint-Like
- Serine Threonine Protein Kinase Chk2
- LFS2 Protein Kinase
- Kinase, LFS2 Protein
- Protein Kinase, LFS2
- CHEK2 Kinase
- Kinase, CHEK2
- hCHK2 Kinase
- Kinase, hCHK2
- Serine-Threonine-Protein Kinase CHK2
- CHK2, Serine-Threonine-Protein Kinase
- Kinase CHK2, Serine-Threonine-Protein
- CDS1 Kinase
- Kinase, CDS1
- PP1425 Protein Kinase
- Kinase, PP1425 Protein
- Protein Kinase, PP1425
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Below are MeSH descriptors whose meaning is more general than "Checkpoint Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Checkpoint Kinase 2".
This graph shows the total number of publications written about "Checkpoint Kinase 2" by people in this website by year, and whether "Checkpoint Kinase 2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2016 | 1 | 0 | 1 |
2022 | 0 | 1 | 1 |
2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Checkpoint Kinase 2" by people in Profiles.
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Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Med. 2023 08; 12(15):16142-16162.
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Reply to: Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients". Int J Cancer. 2023 05 01; 152(9):2013.
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The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients. Int J Cancer. 2023 04 01; 152(7):1388-1398.
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Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. J Clin Oncol. 2016 08 10; 34(23):2750-60.