"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Descriptor ID |
D011493
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MeSH Number(s) |
D08.811.913.696.620.682.700.725
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Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
2000 | 1 | 2 | 3 |
2001 | 2 | 0 | 2 |
2002 | 0 | 1 | 1 |
2014 | 1 | 0 | 1 |
2015 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia. 2022 02; 65(2):301-314.
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A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells. Sci Rep. 2015 Jul 07; 5:11742.
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Role of diacylglycerol activation of PKC? in lipid-induced muscle insulin resistance in humans. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9597-602.
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Enhanced proinflammatory response to endotoxin after priming of macrophages with lead ions. J Leukoc Biol. 2002 Mar; 71(3):417-24.
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Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras. J Biol Chem. 2001 Nov 16; 276(46):42834-42.
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Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells. J Biol Chem. 2001 Aug 24; 276(34):31627-34.
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Selective protein kinase inhibitors block head-specific differentiation in hydra. Cell Signal. 2000 Oct; 12(9-10):649-58.
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Mitochondrial potassium and chloride channels. Acta Biochim Pol. 2000; 47(3):541-51.
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Implication of atypical protein kinase C isozymes lambda and zeta in Ras mediated reorganization of the actin cytoskeleton and cyclin D1-induction. Adv Enzyme Regul. 2000; 40:49-62.
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Ks1, an epithelial cell-specific gene, responds to early signals of head formation in Hydra. Development. 1994 Sep; 120(9):2511-7.