"PAX5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.
| Descriptor ID |
D051757
|
| MeSH Number(s) |
D12.776.260.645.500 D12.776.930.700.500
|
| Concept/Terms |
PAX5 Transcription Factor- PAX5 Transcription Factor
- Transcription Factor, PAX5
- B-Cell-Specific Activator Protein
- B Cell Specific Activator Protein
- Transcription Factor PAX5
- PAX5, Transcription Factor
- Paired Box 5 Protein
- B Cell-Specific Transcription Factor
- B Cell Specific Transcription Factor
- Early B Cell-Specific Binding Protein-1
- Early B Cell Specific Binding Protein 1
|
Below are MeSH descriptors whose meaning is more general than "PAX5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX5 Transcription Factor".
This graph shows the total number of publications written about "PAX5 Transcription Factor" by people in this website by year, and whether "PAX5 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "PAX5 Transcription Factor" by people in Profiles.
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Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia. Eur J Med Genet. 2023 Apr; 66(4):104725.
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PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. EBioMedicine. 2022 Sep; 83:104224.
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Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants. Leukemia. 2022 09; 36(9):2338-2342.
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An intact gut microbiome protects genetically predisposed mice against leukemia. Blood. 2020 10 29; 136(18):2003-2017.
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Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID. Nat Commun. 2019 12 05; 10(1):5563.
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IKZF1plus Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. J Clin Oncol. 2018 04 20; 36(12):1240-1249.
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Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL. Cancer Res. 2018 05 15; 78(10):2669-2679.
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Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483.
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Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ?-catenin signalling and GADD45G expression. J Cell Mol Med. 2016 May; 20(5):842-54.
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GEMMs addressing Pax5 loss-of-function in childhood pB-ALL. Eur J Med Genet. 2016 Mar; 59(3):166-72.
MeSH information
