"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
| Descriptor ID |
D034741
|
| MeSH Number(s) |
D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
|
| Concept/Terms |
RNA, Small Interfering- RNA, Small Interfering
- Interfering RNA, Small
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Small Interfering RNA
- siRNA
Piwi-Interacting RNA- Piwi-Interacting RNA
- Piwi Interacting RNA
- RNA, Piwi-Interacting
- RNA, Piwi Interacting
- piRNA
Short Hairpin RNA- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
- shRNA
Repeat-Associated siRNA- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
Scan RNA- Scan RNA
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- RNA, Scan
Trans-Acting siRNA- Trans-Acting siRNA
- Trans Acting siRNA
- tasiRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
|
Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".
This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 2 | 3 |
| 2004 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 3 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.
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Antiviral RNAi Response against the Insect-Specific Agua Salud Alphavirus. mSphere. 2022 02 23; 7(1):e0100321.
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The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma. Cell Death Dis. 2021 09 28; 12(10):885.
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H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol. 2020 12; 27(12):1165-1177.
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Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020 04 27; 11(1):2039.
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Transgenesis in Hydra to characterize gene function and visualize cell behavior. Nat Protoc. 2019 07; 14(7):2069-2090.
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Landscape of nuclear transport receptor cargo?specificity. Mol Syst Biol. 2017 12 18; 13(12):962.
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Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nat Commun. 2017 06 06; 8:15652.
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Orientia tsutsugamushi Ank9 is a multifunctional effector that utilizes a novel GRIP-like Golgi localization domain for Golgi-to-endoplasmic reticulum trafficking and interacts with host COPB2. Cell Microbiol. 2017 07; 19(7).
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Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein. PLoS Genet. 2016 06; 12(6):e1006095.
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MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5261-70.
MeSH information
