"Parkinson Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Descriptor ID |
D010300
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MeSH Number(s) |
C10.228.140.079.862.500 C10.228.662.600.400 C10.574.812
|
Concept/Terms |
Parkinson Disease- Parkinson Disease
- Idiopathic Parkinson's Disease
- Lewy Body Parkinson Disease
- Lewy Body Parkinson's Disease
- Primary Parkinsonism
- Parkinsonism, Primary
- Parkinson Disease, Idiopathic
- Parkinson's Disease
- Parkinson's Disease, Idiopathic
- Parkinson's Disease, Lewy Body
- Idiopathic Parkinson Disease
- Paralysis Agitans
|
Below are MeSH descriptors whose meaning is more general than "Parkinson Disease".
Below are MeSH descriptors whose meaning is more specific than "Parkinson Disease".
This graph shows the total number of publications written about "Parkinson Disease" by people in this website by year, and whether "Parkinson Disease" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1999 | 1 | 0 | 1 |
2004 | 2 | 0 | 2 |
2006 | 1 | 0 | 1 |
2009 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 1 | 2 | 3 |
2014 | 3 | 0 | 3 |
2015 | 1 | 0 | 1 |
2018 | 0 | 1 | 1 |
2019 | 4 | 0 | 4 |
2020 | 1 | 2 | 3 |
2021 | 1 | 0 | 1 |
2022 | 2 | 0 | 2 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Parkinson Disease" by people in Profiles.
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Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease. Mol Neurodegener. 2023 07 04; 18(1):44.
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Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo. Sci Adv. 2022 11 25; 8(47):eabq6324.
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Morpho-Functional Changes of Nigral Dopamine Neurons in an a-Synuclein Model of Parkinson's Disease. Mov Disord. 2023 02; 38(2):256-266.
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Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function. Sci Rep. 2021 11 09; 11(1):21946.
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Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human a-Synuclein BAC Transgenic Rats. Mov Disord. 2021 03; 36(3):716-728.
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DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs). Sci Rep. 2020 09 30; 10(1):16131.
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The genetic architecture of the human cerebral cortex. Science. 2020 03 20; 367(6484).
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Silhouette-Length-Scaled Gait Parameters for Motor Functional Analysis in Mice and Rats. eNeuro. 2019 Nov/Dec; 6(6).
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Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease. Nat Commun. 2019 09 02; 10(1):3945.
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Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats. Acta Neuropathol. 2019 10; 138(4):535-550.