"Muscular Atrophy, Spinal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
Descriptor ID |
D009134
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MeSH Number(s) |
C10.228.854.468 C10.574.562.500 C10.668.467.500
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Concept/Terms |
Muscular Atrophy, Spinal- Muscular Atrophy, Spinal
- Atrophy, Spinal Muscular
- Spinal Amyotrophy
- Amyotrophies, Spinal
- Amyotrophy, Spinal
- Spinal Amyotrophies
- Spinal Muscular Atrophy
Hereditary Motor Neuronopathy- Hereditary Motor Neuronopathy
- Hereditary Motor Neuronopathies
- Motor Neuronopathies, Hereditary
- Motor Neuronopathy, Hereditary
- Neuronopathies, Hereditary Motor
- Neuronopathy, Hereditary Motor
Scapuloperoneal Form of Spinal Muscular Atrophy- Scapuloperoneal Form of Spinal Muscular Atrophy
- Spinal Muscular Atrophy, Scapuloperoneal Form
- Spinal Muscular Atrophy, Scapuloperoneal
- Amyotrophy, Neurogenic Scapuloperoneal, New England Type
- Scapuloperoneal Spinal Muscular Atrophy
Progressive Muscular Atrophy- Progressive Muscular Atrophy
- Atrophies, Progressive Muscular
- Atrophy, Progressive Muscular
- Muscular Atrophies, Progressive
- Muscular Atrophy, Progressive
- Progressive Muscular Atrophies
- Progressive Myelopathic Muscular Atrophy
- Myelopathic Muscular Atrophy, Progressive
Bulbospinal Neuronopathy- Bulbospinal Neuronopathy
- Bulbospinal Neuronopathies
- Neuronopathies, Bulbospinal
- Neuronopathy, Bulbospinal
Myelopathic Muscular Atrophy- Myelopathic Muscular Atrophy
- Atrophy, Myelopathic Muscular
- Muscular Atrophy, Myelopathic
- Adult-Onset Spinal Muscular Atrophy
- Adult Onset Spinal Muscular Atrophy
- Muscular Atrophy, Adult Spinal
- Adult Spinal Muscular Atrophy
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Below are MeSH descriptors whose meaning is more general than "Muscular Atrophy, Spinal".
Below are MeSH descriptors whose meaning is more specific than "Muscular Atrophy, Spinal".
This graph shows the total number of publications written about "Muscular Atrophy, Spinal" by people in this website by year, and whether "Muscular Atrophy, Spinal" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 1 | 0 | 1 |
2009 | 1 | 0 | 1 |
2015 | 0 | 1 | 1 |
2016 | 1 | 0 | 1 |
2018 | 3 | 0 | 3 |
2021 | 1 | 0 | 1 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Muscular Atrophy, Spinal" by people in Profiles.
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Closing the Gap - Detection of 5q-Spinal Muscular Atrophy by Short-Read Next-Generation Sequencing and Unexpected Results in a Diagnostic Patient Cohort. J Neuromuscul Dis. 2023; 10(5):835-846.
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Genomic variants causing mitochondrial dysfunction are common in hereditary lower motor neuron disease. Hum Mutat. 2021 04; 42(4):460-472.
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Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice. PLoS One. 2018; 13(9):e0203398.
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Targeted sequencing with expanded gene profile enables high diagnostic yield in non-5q-spinal muscular atrophies. Hum Mutat. 2018 09; 39(9):1284-1298.
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Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. 2018 05 21; 8(1):7907.
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Autosomal dominant spinal muscular atrophy with lower extremity predominance: A recognizable phenotype of BICD2 mutations. Muscle Nerve. 2016 09; 54(3):496-500.
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mRNA metabolism and neuronal disease. FEBS Lett. 2015 Jun 22; 589(14):1598-606.
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IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1). Hum Mol Genet. 2009 Apr 01; 18(7):1288-300.
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Visualization of defective mitochondrial function in skeletal muscle fibers of patients with sporadic amyotrophic lateral sclerosis. J Neurol Sci. 1999 Oct 31; 169(1-2):133-9.