"Amyotrophic Lateral Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Descriptor ID |
D000690
|
| MeSH Number(s) |
C10.228.854.139 C10.574.562.250 C10.574.950.050 C10.668.467.250 C18.452.845.800.050
|
| Concept/Terms |
Amyotrophic Lateral Sclerosis- Amyotrophic Lateral Sclerosis
- Sclerosis, Amyotrophic Lateral
- Charcot Disease
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis
- Lou Gehrig Disease
- Lou Gehrig's Disease
- Lou-Gehrigs Disease
- Disease, Lou-Gehrigs
- ALS (Amyotrophic Lateral Sclerosis)
- Gehrig's Disease
- Gehrig Disease
- Gehrigs Disease
Amyotrophic Lateral Sclerosis, Guam Form- Amyotrophic Lateral Sclerosis, Guam Form
- Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
- Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam
- Guam Form of Amyotrophic Lateral Sclerosis
- Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
- Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1
- Guam Disease
- Disease, Guam
|
Below are MeSH descriptors whose meaning is more general than "Amyotrophic Lateral Sclerosis".
Below are MeSH descriptors whose meaning is more specific than "Amyotrophic Lateral Sclerosis".
This graph shows the total number of publications written about "Amyotrophic Lateral Sclerosis" by people in this website by year, and whether "Amyotrophic Lateral Sclerosis" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amyotrophic Lateral Sclerosis" by people in Profiles.
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New Insights into the Neuromyogenic Spectrum of a Gain of Function Mutation in SPTLC1. Genes (Basel). 2022 05 17; 13(5).
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Impairment of mitochondrial oxidative phosphorylation in skin fibroblasts of SALS and FALS patients is rescued by in vitro treatment with ROS scavengers. Exp Neurol. 2021 05; 339:113620.
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The role of de novo mutations in the development of amyotrophic lateral sclerosis. Hum Mutat. 2017 11; 38(11):1534-1541.
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Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis. Muscle Nerve. 2018 02; 57(2):273-278.
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Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nat Genet. 2016 09; 48(9):1043-8.
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De novo FUS mutations are the most frequent genetic cause in early-onset German ALS patients. Neurobiol Aging. 2015 Nov; 36(11):3117.e1-3117.e6.
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RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1428-31.
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Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Eur J Neurosci. 2007 Mar; 25(6):1669-77.
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In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient. Exp Neurol. 2006 Oct; 201(2):293-300.
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Mitochondrial changes in skeletal muscle in amyotrophic lateral sclerosis and other neurogenic atrophies--a comment. Brain. 2005 Dec; 128(Pt 12):E38.
MeSH information
