"Electron Transport Complex IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
| Descriptor ID |
D003576
|
| MeSH Number(s) |
D05.500.562.374 D08.811.600.250.687 D08.811.682.285 D12.776.157.530.450.250.875.304 D12.776.543.277.687 D12.776.543.585.450.250.875.484
|
| Concept/Terms |
Electron Transport Complex IV- Electron Transport Complex IV
- Ferrocytochrome c Oxygen Oxidoreductase
- Cytochrome-c Oxidase (Complex IV)
- Cytochrome Oxidase
- Oxidase, Cytochrome
- Cytochrome-c Oxidase
- Cytochrome c Oxidase
- Oxidase, Cytochrome-c
Signal Peptide p25-Subunit IV Cytochrome Oxidase- Signal Peptide p25-Subunit IV Cytochrome Oxidase
- Signal Peptide p25 Subunit IV Cytochrome Oxidase
- Pre-CTOX p25
- p25 Presequence Peptide-Cytochrome Oxidase
- p25 Presequence Peptide Cytochrome Oxidase
Cytochrome aa3- Cytochrome aa3
- Heme aa3 Cytochrome Oxidase
- Cytochrome a,a3
|
Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex IV".
Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex IV".
This graph shows the total number of publications written about "Electron Transport Complex IV" by people in this website by year, and whether "Electron Transport Complex IV" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 3 | 1 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Electron Transport Complex IV" by people in Profiles.
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Molecular and Functional Effects of Loss of Cytochrome c Oxidase Subunit 8A. Biochemistry (Mosc). 2021 Jan; 86(1):33-43.
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Distinct segregation of the pathogenic m.5667G>A mitochondrial tRNAAsn mutation in extraocular and skeletal muscle in chronic progressive external ophthalmoplegia. Neuromuscul Disord. 2019 05; 29(5):358-367.
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Linear mitochondrial DNA is rapidly degraded by components of the replication machinery. Nat Commun. 2018 04 30; 9(1):1727.
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Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. Brain. 2016 Feb; 139(Pt 2):338-45.
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Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging. Cell Metab. 2015 May 05; 21(5):667-77.
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Oxyphil cell metaplasia in the parathyroids is characterized by somatic mitochondrial DNA mutations in NADH dehydrogenase genes and cytochrome c oxidase activity-impairing genes. Am J Pathol. 2014 Nov; 184(11):2922-35.
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Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion. Acta Neuropathol. 2013 Feb; 125(2):245-56.
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Severe epilepsy as the major symptom of new mutations in the mitochondrial tRNA(Phe) gene. Neurology. 2010 Feb 09; 74(6):507-12.
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Molecular phylogenetics in Hydra, a classical model in evolutionary developmental biology. Mol Phylogenet Evol. 2007 Jul; 44(1):281-90.
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Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells. Neurobiol Dis. 2006 Sep; 23(3):725-30.
MeSH information
