"Nedd4 Ubiquitin Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
| Descriptor ID |
D000075702
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| MeSH Number(s) |
D05.500.199.500 D08.811.464.938.750.257 D12.776.543.990.493.500
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| Concept/Terms |
Nedd4 Ubiquitin Protein Ligases- Nedd4 Ubiquitin Protein Ligases
- Nedd4 Proteins
- Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
- Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
|
Below are MeSH descriptors whose meaning is more general than "Nedd4 Ubiquitin Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Nedd4 Ubiquitin Protein Ligases".
This graph shows the total number of publications written about "Nedd4 Ubiquitin Protein Ligases" by people in this website by year, and whether "Nedd4 Ubiquitin Protein Ligases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nedd4 Ubiquitin Protein Ligases" by people in Profiles.
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Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures. Mol Genet Genomic Med. 2018 11; 6(6):1255-1260.
MeSH information
