"Pain Insensitivity, Congenital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)
| Descriptor ID |
D000699
|
| MeSH Number(s) |
C10.668.829.700 C16.320.775
|
| Concept/Terms |
Pain Insensitivity, Congenital- Pain Insensitivity, Congenital
- Congenital Insensitivity To Pain
- Congenital Pain Indifference
- Congenital Pain Insensitivity
- Insensitivity To Pain, Congenital
- Congenital Analgesia
- Pain Indifference, Congenital
- Congenital Pain Indifferences
- Analgesia, Congenital
- Channelopathy-Associated Insensitivity To Pain
- Congenital Indifference to Pain
- Insensitivity, Congenital Pain
|
Below are MeSH descriptors whose meaning is more general than "Pain Insensitivity, Congenital".
Below are MeSH descriptors whose meaning is more specific than "Pain Insensitivity, Congenital".
This graph shows the total number of publications written about "Pain Insensitivity, Congenital" by people in this website by year, and whether "Pain Insensitivity, Congenital" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pain Insensitivity, Congenital" by people in Profiles.
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Genetic pain loss disorders. Nat Rev Dis Primers. 2022 06 16; 8(1):41.
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Pain insensitivity: distal S6-segment mutations in NaV1.9 emerge as critical hotspot. Neurogenetics. 2017 07; 18(3):179-181.
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Hereditary Sensory Polyneuropathy, Pain Insensitivity and Global Developmental Delay due to Novel Mutation in PRDM12 Gene. Indian J Pediatr. 2017 04; 84(4):332-333.
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Whole exome sequencing in congenital pain insensitivity identifies a novel causative intronic NTRK1-mutation due to uniparental disomy. Am J Med Genet B Neuropsychiatr Genet. 2016 09; 171(6):875-8.
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[Sensory and autonomic neuropathies and pain-related channelopathies]. Schmerz. 2015 Aug; 29(4):445-57.
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Transcriptional regulator PRDM12 is essential for human pain perception. Nat Genet. 2015 Jul; 47(7):803-8.
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The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P. Eur J Hum Genet. 2015 May; 23(5):561-3.
MeSH information
