"MutL Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
| Descriptor ID |
D000070956
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| MeSH Number(s) |
D08.811.074.766 D08.811.277.040.025.215 D12.776.260.540
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "MutL Proteins".
Below are MeSH descriptors whose meaning is more specific than "MutL Proteins".
This graph shows the total number of publications written about "MutL Proteins" by people in this website by year, and whether "MutL Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "MutL Proteins" by people in Profiles.
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Whole-genome sequencing enabling the detection of a colistin-resistant hypermutating Citrobacter werkmanii strain harbouring a novel metallo-?-lactamase VIM-48. Int J Antimicrob Agents. 2018 Jun; 51(6):867-874.
MeSH information
