"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor ID |
D017209
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MeSH Number(s) |
G04.146.160
|
Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
2001 | 0 | 1 | 1 |
2002 | 0 | 3 | 3 |
2003 | 0 | 2 | 2 |
2005 | 3 | 0 | 3 |
2006 | 1 | 1 | 2 |
2007 | 1 | 1 | 2 |
2008 | 1 | 0 | 1 |
2009 | 2 | 1 | 3 |
2010 | 1 | 2 | 3 |
2011 | 0 | 3 | 3 |
2012 | 1 | 2 | 3 |
2013 | 1 | 7 | 8 |
2014 | 1 | 5 | 6 |
2015 | 2 | 8 | 10 |
2016 | 1 | 5 | 6 |
2017 | 2 | 3 | 5 |
2018 | 1 | 6 | 7 |
2019 | 1 | 9 | 10 |
2020 | 2 | 4 | 6 |
2021 | 0 | 3 | 3 |
2022 | 1 | 2 | 3 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Sublethal necroptosis signaling promotes inflammation and liver cancer. Immunity. 2023 07 11; 56(7):1578-1595.e8.
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Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma. Int J Mol Sci. 2022 May 05; 23(9).
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The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends Genet. 2022 06; 38(6):598-612.
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Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy. Nat Commun. 2022 02 04; 13(1):701.
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Epigenetic Priming of Bladder Cancer Cells With Decitabine Increases Cytotoxicity of Human EGFR and CD44v6 CAR Engineered T-Cells. Front Immunol. 2021; 12:782448.
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4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J Med Chem. 2021 10 14; 64(19):14620-14646.
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The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells. Cells. 2021 04 28; 10(5).
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Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors. Eur J Med Chem. 2021 Feb 05; 211:113095.
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Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs). Angew Chem Int Ed Engl. 2020 12 07; 59(50):22494-22499.
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Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression. Breast Cancer Res. 2020 07 13; 22(1):75.