"Caspase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Descriptor ID |
D053181
|
MeSH Number(s) |
D08.811.277.656.262.500.126.550.800 D08.811.277.656.300.200.126.550.800 D12.644.360.024.285.037 D12.644.360.075.405.550.800 D12.644.360.075.421.037 D12.776.157.057.018.037 D12.776.476.024.320.025 D12.776.476.075.405.550.800 D12.776.476.075.421.037
|
Concept/Terms |
Caspase 8- Caspase 8
- FLICE Protein
- Mch5 Protease
- Caspase-8
- CAP4 Protease
- MACH Protein
Procaspase-8- Procaspase-8
- Procaspase 8
- Pro-Caspase-8
- Pro Caspase 8
|
Below are MeSH descriptors whose meaning is more general than "Caspase 8".
Below are MeSH descriptors whose meaning is more specific than "Caspase 8".
This graph shows the total number of publications written about "Caspase 8" by people in this website by year, and whether "Caspase 8" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2014 | 1 | 0 | 1 |
2015 | 0 | 3 | 3 |
2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 8" by people in Profiles.
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FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity. 2020 06 16; 52(6):978-993.e6.
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Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease. Haematologica. 2015 Sep; 100(9):1189-98.
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors. Oncotarget. 2015 Jun 20; 6(17):15425-35.
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Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli. PLoS One. 2015; 10(4):e0121103.
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Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet. 2015 Jan 01; 24(1):285-98.