"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
| Descriptor ID |
D051033
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| MeSH Number(s) |
D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063
|
| Concept/Terms |
Apoptosis Inducing Factor- Apoptosis Inducing Factor
- Apoptosis-Inducing Factor
- Mitochondrial Apoptosis-Inducing Factor
- Apoptosis-Inducing Factor, Mitochondrial
- Mitochondrial Apoptosis Inducing Factor
- AIF Apoptosis Regulatory Protein
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Below are MeSH descriptors whose meaning is more general than "Apoptosis Inducing Factor".
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MeSH information
