"DNA (Cytosine-5-)-Methyltransferase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
| Descriptor ID |
D000076123
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| MeSH Number(s) |
D08.811.913.555.500.350.100.500.500 D12.776.157.687.313 D12.776.660.720.313
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA (Cytosine-5-)-Methyltransferase 1".
Below are MeSH descriptors whose meaning is more specific than "DNA (Cytosine-5-)-Methyltransferase 1".
This graph shows the total number of publications written about "DNA (Cytosine-5-)-Methyltransferase 1" by people in this website by year, and whether "DNA (Cytosine-5-)-Methyltransferase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA (Cytosine-5-)-Methyltransferase 1" by people in Profiles.
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DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons. Cereb Cortex. 2020 06 01; 30(7):3921-3937.
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Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. PLoS One. 2012; 7(12):e52629.
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Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. Int J Cancer. 2009 Oct 01; 125(7):1626-39.
MeSH information
