"Gene Targeting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
Descriptor ID |
D018390
|
MeSH Number(s) |
E05.393.335
|
Concept/Terms |
Gene Targeting- Gene Targeting
- Gene Targetings
- Targeting, Gene
- Targetings, Gene
|
Below are MeSH descriptors whose meaning is more general than "Gene Targeting".
Below are MeSH descriptors whose meaning is more specific than "Gene Targeting".
This graph shows the total number of publications written about "Gene Targeting" by people in this website by year, and whether "Gene Targeting" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2002 | 0 | 2 | 2 |
2004 | 0 | 1 | 1 |
2006 | 2 | 1 | 3 |
2007 | 0 | 1 | 1 |
2008 | 0 | 1 | 1 |
2014 | 1 | 0 | 1 |
2015 | 1 | 1 | 2 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Targeting" by people in Profiles.
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CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing. Nucleic Acids Res. 2019 07 02; 47(W1):W171-W174.
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Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR. Genome Biol. 2015 Dec 16; 16:281.
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GEMMs addressing Pax5 loss-of-function in childhood pB-ALL. Eur J Med Genet. 2016 Mar; 59(3):166-72.
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Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun. 2014; 5:3045.
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Specific gene silencing by artificial MicroRNAs in Physcomitrella patens: an alternative to targeted gene knockouts. Plant Physiol. 2008 Oct; 148(2):684-93.
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Human resting CD4+ T cells are constitutively inhibited by TGF beta under steady-state conditions. J Immunol. 2007 Jun 01; 178(11):6931-40.
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Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. Mol Cell Biol. 2007 Feb; 27(4):1370-9.
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Decoding non-unique oligonucleotide hybridization experiments of targets related by a phylogenetic tree. Bioinformatics. 2006 Jul 15; 22(14):e424-30.
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Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold. Mol Cell Biol. 2006 Jan; 26(1):182-91.
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RNA interference as a potential tool in the treatment of leukaemia. Expert Opin Biol Ther. 2004 Dec; 4(12):1921-9.