"Desmin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.
Descriptor ID |
D003893
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MeSH Number(s) |
D05.750.078.593.200 D12.776.220.475.200
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Desmin".
Below are MeSH descriptors whose meaning is more specific than "Desmin".
This graph shows the total number of publications written about "Desmin" by people in this website by year, and whether "Desmin" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 1 | 1 | 2 |
2008 | 1 | 0 | 1 |
2016 | 2 | 0 | 2 |
2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Desmin" by people in Profiles.
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Heart failure after pressure overload in autosomal-dominant desminopathies: Lessons from heterozygous DES-p.R349P knock-in mice. PLoS One. 2020; 15(3):e0228913.
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Neuromuscular endplate pathology in recessive desminopathies: Lessons from man and mice. Neurology. 2016 Aug 23; 87(8):799-805.
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Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue. Acta Neuropathol. 2016 09; 132(3):453-73.
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Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms. J Cell Biol. 2008 May 19; 181(4):667-81.
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On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria. Hum Mol Genet. 2003 Mar 15; 12(6):657-69.
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Mitochondrial dysfunction in myofibrillar myopathy. Neuropathol Appl Neurobiol. 2003 Feb; 29(1):45-51.