"Caffeine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Descriptor ID |
D002110
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MeSH Number(s) |
D03.132.960.175 D03.633.100.759.758.824.175
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caffeine".
Below are MeSH descriptors whose meaning is more specific than "Caffeine".
This graph shows the total number of publications written about "Caffeine" by people in this website by year, and whether "Caffeine" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
2011 | 1 | 0 | 1 |
2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Caffeine" by people in Profiles.
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Lipidomic Response to Coffee Consumption. Nutrients. 2018 Dec 01; 10(12).
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CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. PLoS Biol. 2018 06; 16(6):e2004408.
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Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. Pharmacogenet Genomics. 2011 Oct; 21(10):673-8.
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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr. 2010 Apr; 91(4):950-7.
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Caffeine and Ca2+ stimulate mitochondrial oxidative phosphorylation in saponin-skinned human skeletal muscle fibers due to activation of actomyosin ATPase. Biochim Biophys Acta. 1994 Dec 30; 1188(3):373-9.
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Mitochondrial oxidative phosphorylation in saponin-skinned human muscle fibers is stimulated by caffeine. FEBS Lett. 1993 May 24; 323(1-2):188-90.
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Use of NAD(P)H and flavoprotein fluorescence signals to characterize the redox state of pyridine nucleotides in epididymal bull spermatozoa. Biochim Biophys Acta. 1991 Feb 08; 1056(3):273-8.
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Interdependence of mitochondrial ATP production and extramitochondrial ATP utilization in intact spermatozoa. Biochim Biophys Acta. 1985 Jul 17; 808(2):316-22.