"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Descriptor ID |
D001057
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MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2005 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
2011 | 2 | 0 | 2 |
2013 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2015 | 1 | 0 | 1 |
2016 | 0 | 1 | 1 |
2018 | 1 | 0 | 1 |
2021 | 0 | 1 | 1 |
2022 | 0 | 1 | 1 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Current allele distribution of the human longevity gene APOE in Europe can mainly be explained by ancient admixture. Aging Cell. 2023 05; 22(5):e13819.
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Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score. Int J Mol Sci. 2022 Sep 19; 23(18).
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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 2021 06 07; 12(1):3417.
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Protein markers and risk of type 2 diabetes and prediabetes: a targeted proteomics approach in the KORA F4/FF4 study. Eur J Epidemiol. 2019 Apr; 34(4):409-422.
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Estrogen receptor beta polymorphisms and cognitive performance in women: associations and modifications by genetic and environmental influences. J Neural Transm (Vienna). 2016 12; 123(12):1369-1379.
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Deficiency in lymphotoxin ? receptor protects from atherosclerosis in apoE-deficient mice. Circ Res. 2015 Apr 10; 116(8):e57-68.
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Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice. Br J Pharmacol. 2014 Nov; 171(22):5032-48.
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Stem cells and aging from a quasi-immortal point of view. Bioessays. 2013 Nov; 35(11):994-1003.
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Inactivation of CD73 promotes atherogenesis in apolipoprotein E-deficient mice. Cardiovasc Res. 2011 Nov 01; 92(2):338-47.
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A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech Ageing Dev. 2011 Jun-Jul; 132(6-7):324-30.