"Histocompatibility Antigens Class II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Descriptor ID |
D000949
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MeSH Number(s) |
D12.776.395.550.509 D12.776.543.550.440 D23.050.301.500.400 D23.050.705.552.410
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Concept/Terms |
Histocompatibility Antigens Class II- Histocompatibility Antigens Class II
- Class II Antigens
- Antigens, Class II
- Class II Histocompatibility Antigens
- Ia-Like Antigens
- Antigens, Ia-Like
- Ia Like Antigens
- IA Antigen
- Antigen, IA
- I-A Antigen
- Antigen, I-A
- Antigens, Immune Response
- Immune Response Antigens
- Immune-Response-Associated Antigens
- Antigens, Immune-Response-Associated
- Immune Response Associated Antigens
- Class II Major Histocompatibility Antigens
- I-A-Antigen
- I A Antigen
- Class II Antigen
- Antigen, Class II
- Ia Antigens
- Antigens, Ia
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Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class II".
Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class II".
This graph shows the total number of publications written about "Histocompatibility Antigens Class II" by people in this website by year, and whether "Histocompatibility Antigens Class II" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
2013 | 1 | 1 | 2 |
2016 | 0 | 1 | 1 |
2019 | 1 | 1 | 2 |
2020 | 2 | 0 | 2 |
2021 | 0 | 1 | 1 |
2023 | 1 | 2 | 3 |
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Below are the most recent publications written about "Histocompatibility Antigens Class II" by people in Profiles.
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Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins. Front Immunol. 2023; 14:1107266.
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Complete sequences of six major histocompatibility complex haplotypes, including all the major MHC class II structures. HLA. 2023 07; 102(1):28-43.
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A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies. Brain. 2023 03 01; 146(3):977-990.
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HLA-E expression constitutes a novel determinant for ALL disease monitoring following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2021 07; 56(7):1723-1727.
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Unbiased Characterization of Peptide-HLA Class II Interactions Based on Large-Scale Peptide Microarrays; Assessment of the Impact on HLA Class II Ligand and Epitope Prediction. Front Immunol. 2020; 11:1705.
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Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Sci Rep. 2020 04 30; 10(1):7339.
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Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles. Hum Mol Genet. 2019 06 15; 28(12):2078-2092.
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Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Science. 2019 03 15; 363(6432).
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Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors. Sci Rep. 2016 11 28; 6:37462.
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Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19; 39(3):599-610.