"Kelch-Like ECH-Associated Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
| Descriptor ID |
D000072019
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| MeSH Number(s) |
D12.644.360.024.306 D12.776.157.057.067 D12.776.476.024.387
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Kelch-Like ECH-Associated Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Kelch-Like ECH-Associated Protein 1".
This graph shows the total number of publications written about "Kelch-Like ECH-Associated Protein 1" by people in this website by year, and whether "Kelch-Like ECH-Associated Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kelch-Like ECH-Associated Protein 1" by people in Profiles.
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Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines. Sci Rep. 2019 10 09; 9(1):14476.
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Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. Nat Commun. 2017 10 10; 8(1):818.
MeSH information
