"Dishevelled Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
| Descriptor ID |
D000072261
|
| MeSH Number(s) |
D12.644.360.024.288 D12.776.157.057.028 D12.776.476.024.330
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dishevelled Proteins".
Below are MeSH descriptors whose meaning is more specific than "Dishevelled Proteins".
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MeSH information
