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Oikonomou A, Valsecchi L, Quadri M, Watrin T, Scharov K, Procopio S, Tu JW, Vogt M, Savino AM, Silvestri D, Valsecchi MG, Biondi A, Borkhardt A, Bhatia S, Cazzaniga G, Fazio G, Bardini M, Palmi C. High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia. Biochem Pharmacol. 2023 Sep 17; 217:115809. PMID: 37717691.
Spory L, Zimmermann J, Vossen-Gajcy M, Beder T, Bastian L, Alsadeq A, Winterberg D, Vogiatzi F, Wirbelauer T, Bhat H, Borkhardt A, Bhatia S, Schrappe M, Cario G, Schewe DM, Lenk L. AP-1 Transcription Factor Complex Members FOSB and FOS are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL. Hemasphere. 2023 Sep; 7(9):e945. PMID: 37670804; PMCID: PMC10476750.
Citations:
Stachura P, Liu W, Xu HC, Wlodarczyk A, Stencel O, Pandey P, Vogt M, Bhatia S, Picard D, Remke M, Lang KS, H?ussinger D, Homey B, Lang PA, Borkhardt A, Pandyra AA. Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors. Mol Cancer. 2023 08 15; 22(1):136. PMID: 37582744; PMCID: PMC10426104.
Wurnig S, Vogt M, Hogenkamp J, Dienstbier N, Borkhardt A, Bhatia S, Hansen FK. Development of the first geldanamycin-based HSP90 degraders. Front Chem. 2023; 11:1219883. PMID: 37448856; PMCID: PMC10336212.
Citations:
Palmi C, Bresolin S, Junk S, Fazio G, Silvestri D, Zaliova M, Oikonomou A, Scharov K, Stanulla M, Moericke A, Zimmermann M, Schrappe M, Buldini B, Bhatia S, Borkhardt A, Saitta C, Galbiati M, Bardini M, Lo Nigro L, Conter V, Valsecchi MG, Biondi A, Te Kronnie G, Cario G, Cazzaniga G. Definition and Prognostic Value of Ph-like and IKZF1plus Status in Children With Down Syndrome and B-cell Precursor Acute Lymphoblastic Leukemia. Hemasphere. 2023 Jun; 7(6):e892. PMID: 37304931; PMCID: PMC10256328.
Citations:
Wellbrock M, Spix C, Ronckers CM, Grabow D, Filbert AL, Borkhardt A, Wollschl?ger D, Erdmann F. Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register-study based on data from the German Childhood Cancer Registry. Int J Cancer. 2023 08 15; 153(4):742-755. PMID: 37158619.
Wagener R, Brozou T, Erlacher M, Borkhardt A, Friedrich UA, Bienias M, Zinke C, Prazenicova M, Lohse J, Jahn A, Menzel M, Langanke J, Walter C, Varghese J, Dugas M, Schr?ck E, Suttorp M, Hauer J, Auer F. A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children. Genet Med. 2023 08; 25(8):100875. PMID: 37149759.
Tramsen L, Bochennek K, Sparber-Sauer M, Salzmann-Manrique E, Scheer M, Dantonello T, Borkhardt A, Dirksen U, Thorwarth A, Greiner J, Ebinger M, Weclawek-Tompol J, Ladenstein R, Ljungman G, Hallmen E, Lehrnbecher T, Koscielniak E, Klingebiel T. Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials. Cancers (Basel). 2023 Mar 30; 15(7). PMID: 37046711; PMCID: PMC10093505.
Stachura P, Stencel O, Lu Z, Borkhardt A, Pandyra AA. Arenaviruses: Old viruses present new solutions for cancer therapy. Front Immunol. 2023; 14:1110522. PMID: 37033933; PMCID: PMC10079900.
Borkhardt A, Henze G. B-cell precursor leukemias with MYC-rearrangement come into the limelight. Haematologica. 2023 03 01; 108(3):659-660. PMID: 35484663; PMCID: PMC9973467.
Brozou T, Yasin L, Brandes D, Picard D, Walter C, Varghese J, Dugas M, Fischer U, Borkhardt A, Haas OA. Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies. Front Pediatr. 2022; 10:1080347. PMID: 36824296; PMCID: PMC9941195.
Citations:
R?chel N, Oldenburg M, Janssen S, Pandyra AA, Liu W, Vasileiou E, Hein D, Jepsen VH, Fischer U, Picard D, K?gler G, Hauer J, Auer F, Beer A, Adams O, MacKenzie C, Jaeger M, Netea MG, Borkhardt A, G?ssling KL. Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens. Hemasphere. 2023 Feb; 7(2):e835. PMID: 36741356; PMCID: PMC9891444.
Borkhardt A, Wagener R, Brozou T. Reply to: Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients". Int J Cancer. 2023 05 01; 152(9):2013. PMID: 36647327.
Junk SV, Schaeffeler E, Zimmermann M, M?ricke A, Beier R, Sch?tte P, Fedders B, Alten J, Hinze L, Klein N, Kulozik A, Muckenthaler MU, Koehler R, Borkhardt A, Vijayakrishnan J, Ellinghaus D, Forster M, Franke A, Wintering A, Kratz CP, Schrappe M, Schwab M, Houlston RS, Cario G, Stanulla M. Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group. J Exp Clin Cancer Res. 2023 Jan 13; 42(1):21. PMID: 36639636.
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Bl?mel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, W?lfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, St?hler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S. Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation. J Immunother Cancer. 2023 01; 11(1). PMID: 36639156; PMCID: PMC9843227.
Wagener R, Walter C, Auer F, Alzoubi D, Hauer J, Fischer U, Varghese J, Dugas M, Borkhardt A, Brozou T. The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients. Int J Cancer. 2023 04 01; 152(7):1388-1398. PMID: 36468172.
Sinatra L, Yang J, Schliehe-Diecks J, Dienstbier N, Vogt M, Gebing P, Bachmann LM, S?nnichsen M, Lenz T, St?hler K, Sch?ler A, Borkhardt A, Bhatia S, Hansen FK. Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity. J Med Chem. 2022 Dec 06. PMID: 36473103.
Re?ing N, Schliehe-Diecks J, Watson PR, S?nnichsen M, Cragin AD, Sch?ler A, Yang J, Sch?ker-H?bner L, Borkhardt A, Christianson DW, Bhatia S, Hansen FK. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J Med Chem. 2022 Nov 24; 65(22):15457-15472. PMID: 36351184; PMCID: PMC9691607.
Borkhardt A, Sch?z J, Tr?benbach C, Wellbrock M, Spix C, Erdmann F. Temporal changes of the incidence of childhood B-cell precursor acute lymphoblastic leukaemia in Germany during the COVID-19 pandemic. Leukemia. 2022 12; 36(12):2908-2911. PMID: 36289349; PMCID: PMC9607786.
Haas OA, Borkhardt A. Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children. Leukemia. 2022 12; 36(12):2769-2783. PMID: 36266323; PMCID: PMC9712104.
Bielack SS, Blattmann C, Borkhardt A, Cs?ka M, Hassenpflug W, Kab?ckov? E, Kager L, Kessler T, Kratz C, K?hne T, Kevric M, Lehrnbecher T, Mayer-Steinacker R, Mettmann V, Metzler M, Reichardt P, Rossig C, Sorg B, von Luettichau I, Windhager R, Hecker-Nolting S. Osteosarcoma and causes of death: A report of 1520 deceased patients from the Cooperative Osteosarcoma Study Group (COSS). Eur J Cancer. 2022 Nov; 176:50-57. PMID: 36191386.
Mezger K, Ebert S, Muhle HE, Stadt UZ, Borkhardt A, Dilloo D, Faber J, Feuchtinger T, Imschweiler T, Jorch N, Pekrun A, Schmid I, Schramm F, Zimmermann M, Horstmann MA, Escherich G. Amsacrine combined with etoposide and methylprednisolone is a feasible and safe component in first-line intensified treatment of pediatric patients with high-risk acute lymphoblastic leukemia in CoALL08-09 trial. Pediatr Blood Cancer. 2022 12; 69(12):e29997. PMID: 36129234.
Bl?mel L, Qin N, Berlandi J, Paisana E, Casc?o R, Cust?dia C, Pauck D, Picard D, Langini M, St?hler K, Meyer FD, G?bbels S, Malzkorn B, Liebau MC, Barata JT, Jeibmann A, Kerl K, Erkek S, Kool M, Pfister SM, Johann PD, Fr?hwald MC, Borkhardt A, Reifenberger G, Faria CC, Fischer U, Hasselblatt M, Bartl J, Remke M. Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors. Cell Death Dis. 2022 Sep 20; 13(9):806. PMID: 36127323; PMCID: PMC9489777.
Loizou L, Demetriou A, Erdmann F, Borkhardt A, Brozou T, Sharp L, McNally R. Patterns and temporal trends in the incidence of childhood and adolescence cancer in Cyprus 1998-2017: A population-based study from the Cyprus Paediatric Oncology Registry. Cancer Epidemiol. 2022 10; 80:102239. PMID: 35994888.
Fazio G, Bresolin S, Silvestri D, Quadri M, Saitta C, Vendramini E, Buldini B, Palmi C, Bardini M, Grioni A, Rigamonti S, Galbiati M, Mecca S, Savino AM, Peloso A, Tu JW, Bhatia S, Borkhardt A, Micalizzi C, Lo Nigro L, Locatelli F, Conter V, Rizzari C, Valsecchi MG, Te Kronnie G, Biondi A, Cazzaniga G. PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. EBioMedicine. 2022 Sep; 83:104224. PMID: 35985167; PMCID: PMC9403348.
Escudero A, Takagi M, Friedrich UA, Miyamoto S, Ogawa A, Imai K, Pascual B, Stepensky P, Yasin L, Elitzur S, Borkhardt A, Auer F, Vela M, P?rez-Mart?nez A, Hauer J. Clinical and immunophenotypic characteristics of familial leukemia predisposition caused by PAX5 germline variants. Leukemia. 2022 09; 36(9):2338-2342. PMID: 35902733.
Wellbrock M, Zeeb H, Spix C, Grabow D, Borkhardt A, Erdmann F. Survival in Children Below the Age of 15 Years With Leukemia: Temporal Patterns in Eastern and Western Germany Since German Reunification. Hemasphere. 2022 Aug; 6(8):e755. PMID: 35935611; PMCID: PMC9351893.
Citations:
Zanini M, Bernardi F, Forget A, Talbot J, Cancila G, Gao Q, Yu H, Souphron J, Rotblat B, Diederichs S, Ramaswamy V, Suzuki H, Oro A, Buell A, Lichter P, Northcott PA, Taylor MD, Ayrault O, Bartl J, Bl?mel L, Picard D, Qin N, Nath S, Koumba IM, Wolter M, Kuonen F, Langini M, Beez T, Munoz C, Pauck D, Marquardt V, Korsch M, M?lders C, Berger D, G?bbels S, Meyer FD, Scheffler B, St?hler K, Stefanski A, Fischer U, Leprivier G, Willbold D, Steger G, Kool M, Pfister SM, Borkhardt A, Reifenberger G, Remke M. The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nat Commun. 2022 07 13; 13(1):4061. PMID: 35831316; PMCID: PMC9279496.
Rohde M, Dave S, Tzankov A, Dugas M, Haferlach T, Kern W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Siebert R, Strahm B, Woessmann W, Zimmermann M, Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Borkhardt A, Burmeister T, Sandmann S, Fend F, Finger J, Mueller S, G?kbuget N, Hartmann W, Rosenwald A, von Stackelberg A, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 07 06; 13(1):3881. PMID: 35794096; PMCID: PMC9259584.
Erdmann F, Spix C, Schrappe M, Borkhardt A, Sch?z J. Temporal changes of the incidence of childhood cancer in Germany during the COVID-19 pandemic: Updated analyses from the German Childhood Cancer Registry. Lancet Reg Health Eur. 2022 Jun; 17:100398. PMID: 35573974; PMCID: PMC9091810.
Yoshimi A, Grinstein L, Escherich G, Naami N, Borkhardt A. Thirteen-month-old girl with hyporegenerative macrocytic anemia due to Brown-Vialetto-Van Laere syndrome 2. Am J Hematol. 2022 Nov; 97(11):1495-1496. PMID: 35441393.
Wagener R, Brandes D, Soura S, Alzoubi D, Yasin L, Fischer U, Borkhardt A, Brozou T, Walter C, Surowy HM, Dugas M. Noncancer-related Secondary Findings in a Cohort of 231 Children With Cancer and Their Parents. J Pediatr Hematol Oncol. 2023 03 01; 45(2):e244-e248. PMID: 35537032.
Escherich G, Zur Stadt U, Borkhardt A, Dilloo D, Feuchtinger T, Imschweiler T, Jorch N, Pekrun A, Schmid I, Schramm F, Spohn M, Zimmermann M, Horstmann MA, Faber J. Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group. Haematologica. 2022 05 01; 107(5):1026-1033. PMID: 34348455; PMCID: PMC9052901.
Hauer J, Hansen FK, Bhatia S, Spanier L, Bickel D, Dienstbier N, Woloschin V, Vogt M, Pols H, Lungerich B, Reiners J, Aghaallaei N, Diedrich D, Frieg B, Schliehe-Diecks J, Bopp B, Lang F, Gopalswamy M, Loschwitz J, Bajohgli B, Skokowa J, Borkhardt A, Smits SHJ, Jose J, Gohlke H, Kurz T. Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization. ACS Cent Sci. 2022 May 25; 8(5):636-655. PMID: 35647282; PMCID: PMC9136973.
Pastorczak A, Attarbaschi A, Bomken S, van der Werff Ten Bosch J, Elitzur S, Gennery AR, Hlavackova E, Mlynarski W, Szczepanski T, Wassenberg T, Borkhardt A, Kerekes A, Krenov? Z, Loeffen J. Consensus Recommendations for the Clinical Management of Hematological Malignancies in Patients with DNA Double Stranded Break Disorders. Cancers (Basel). 2022 Apr 14; 14(8). PMID: 35454905; PMCID: PMC9029535.
Bouaoun L, Erdmann F, Sch?z J, Borkhardt A. The impact of the COVID-19 pandemic on the future incidence of acute lymphoblastic leukaemia in children: Projections for Germany under a COVID-19 related scenario. Int J Cancer. 2022 07 01; 151(1):153-155. PMID: 35253908; PMCID: PMC9087532.
R?chel N, Jepsen VH, Hein D, Fischer U, Borkhardt A, G?ssling KL. In Utero Development and Immunosurveillance of B Cell Acute Lymphoblastic Leukemia. Curr Treat Options Oncol. 2022 04; 23(4):543-561. PMID: 35294722; PMCID: PMC8924576.
von Bredow L, Tretbar M, Stopper D, Kraft FB, Hansen FK, Sch?fer TM, Hogenkamp J, Schliehe-Diecks J, Sch?ler A, Borkhardt A, Bhatia S, Held J. Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin-HDAC Inhibitor Hybrids as Multitarget Drugs. Pharmaceuticals (Basel). 2022 Mar 09; 15(3). PMID: 35337131; PMCID: PMC8952208.
Geron I, Savino AM, Fishman H, Tal N, Brown J, Turati VA, James C, Sarno J, Hameiri-Grossman M, Lee YN, Rein A, Maniriho H, Birger Y, Zemlyansky A, Muler I, Davis KL, Marcu-Malina V, Mattson N, Parnas O, Jamieson CHM, Chen CW, Kirsch IR, Nagler A, Enver T, Izraeli S, Wagener R, Fischer U, Barata JT, M?schen M, Borkhardt A. An instructive role for Interleukin-7 receptor a in the development of human B-cell precursor leukemia. Nat Commun. 2022 02 03; 13(1):659. PMID: 35115489; PMCID: PMC8814001.
Schmitz AK, Munoz-Bendix C, Remke M, Brozou T, Borkhardt A, H?nggi D, Beez T. Second-look surgery after pediatric brain tumor resection - Single center analysis of morbidity and volumetric efficacy. Brain Spine. 2022; 2:100865. PMID: 36248154; PMCID: PMC9560669.
Haas OA, Borkhardt A. Chromosomal risk classification in high hyperdiploid acute lymphocytic leukaemia: the beginning of a new chapter. Lancet Haematol. 2022 01; 9(1):e9. PMID: 34971585.
Lang KS, Roesch A, Lang PA, Liu W, Stachura P, Xu HC, V?raljai R, Shinde P, Ganesh NU, Mack M, Van Lierop A, Huang A, Sundaram B, Picard D, Fischer U, Remke M, Homey B, H?ussinger D, Borkhardt A, Pandyra AA. BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment. Cancer Res. 2022 01 15; 82(2):264-277. PMID: 34810198; PMCID: PMC9397630.
McHardy AC, L?hnemann D, K?ster J, Fischer U, Borkhardt A, Sch?nhuth A. Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo. Nat Commun. 2021 11 18; 12(1):6744. PMID: 34795237; PMCID: PMC8602313.
Michler P, Schedel A, Witschas M, Friedrich UA, Wagener R, Mehtonen J, Brozou T, Menzel M, Walter C, Pearce G, Erlacher M, Dugas M, Borkhardt A, Hauer J, Auer F, Nabi D, G?hring G, Hein?niemi M, St?lzel F. Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood. Int J Mol Sci. 2021 Oct 26; 22(21). PMID: 34769003; PMCID: PMC8583981.
Debisarun PA, Bulut O, Kilic G, Zoodsma M, Liu Z, Oldenburg M, Zhang B, Xu CJ, Struycken P, Koeken VACM, Moorlag SJCFM, Taks E, Ostermann PN, Schaal H, Adams O, Borkhardt A, Ten Oever J, van Crevel R, Li Y, Netea MG, G?ssling KL, R?chel N, Dom?nguez-Andr?s J, M?ller L. Induction of trained immunity by influenza vaccination - impact on COVID-19. PLoS Pathog. 2021 10; 17(10):e1009928. PMID: 34695164; PMCID: PMC8568262.
Hauer J, Fischer U, Borkhardt A. Toward prevention of childhood ALL by early-life immune training. Blood. 2021 10 21; 138(16):1412-1428. PMID: 34010407; PMCID: PMC8532195.
Sch?ker-H?bner L, Warstat R, Ahlert H, Mishra P, Kraft FB, Schliehe-Diecks J, Sch?ler A, Borkhardt A, Breit B, Bhatia S, H?gle M, G?nther S, Hansen FK. 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J Med Chem. 2021 10 14; 64(19):14620-14646. PMID: 34582215.
Ahmadov U, Picard D, Bartl J, Silginer M, Trajkovic-Arsic M, Qin N, Pauck D, Winkelkotte AM, Marquardt V, Sander F, Hassiepen C, Kaufhold A, Meyer FD, Kleinesudeik L, Schramm A, Fulda S, Siveke JT, Borkhardt A, Weller M, Roth P, Reifenberger G, Remke M, Bl?mel L, Wolter M, Lim JKM, Melcher M, Langini M, Stefanski A, Steltgens S, Seibt A, Hain A, M?nk C, Knobbe-Thomsen CB, Fischer U, Leprivier G, St?hler K, Distelmaier F. The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma. Cell Death Dis. 2021 09 28; 12(10):885. PMID: 34584066; PMCID: PMC8478910.
Dinkelbach L, Hillebrecht M, Adams O, Dechert O, Trocan L, Neubert J, Borkhardt A, B?tticher B, Jan?en G. High rate of clinically unrecognized SARS-CoV-2 infections in pediatric palliative care patients. Eur J Pediatr. 2022 Feb; 181(2):847-851. PMID: 34467455; PMCID: PMC8408038.
van Tilburg CM, Pfaff E, Pajtler KW, Fiesel P, Jones BC, Balasubramanian GP, Stark S, Johann PD, Blattner-Johnson M, Schramm K, Dikow N, Hirsch S, Sutter C, Grund K, von Stackelberg A, Kulozik AE, Lissat A, Borkhardt A, Meisel R, Reinhardt D, Klusmann JH, Fleischhack G, Tippelt S, von Schweinitz D, Schmid I, Calaminus G, Vorwerk P, Graf N, Westermann F, Fischer M, Eggert A, Nathrath M, Hecker-Nolting S, Schneider DT, Brecht IB, Ketteler P, Fulda S, Koscielniak E, Meister MT, Scheer M, Hettmer S, Schwab M, Tremmel R, Hutter C, Gerber NU, Lohi O, Kazanowska B, Kattamis A, Filippidou M, Milde T, Wolf S, Reuss D, Sahm F, von Deimling A, Dirksen U, Freitag A, Witt R, Lichter P, Kopp-Schneider A, Jones DTW, Capper D, Pfister SM, Witt O, Langenberg KPS, Kramm CM, von Bueren AO, Burkhardt B, W??mann W, Fr?hwald MC, ?ra I, Goemans B, Zwaan CM, J?ger N, Molenaar JJ. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov. 2021 11; 11(11):2764-2779. PMID: 34373263.
Loizou L, Demetriou A, Erdmann F, Borkhardt A, Brozou T, Sharp L, McNally R. Increasing incidence and survival of paediatric and adolescent thyroid cancer in Cyprus 1998-2017: A population-based study from the Cyprus Pediatric Oncology Registry. Cancer Epidemiol. 2021 10; 74:101979. PMID: 34247065.
Janssen S, Zeus M, Laws HJ, Fischer U, Borkhardt A, Oommen PT. Results from a?pilot study on the oral microbiome in children and adolescents with chronic nonbacterial osteomyelitis. Z Rheumatol. 2023 Mar; 82(2):123-133. PMID: 34196794; PMCID: PMC9981501.
Wellbrock M, Spix C, Grabow D, Borkhardt A, Zeeb H, Erdmann F. 28-year incidence and time trends of childhood leukaemia in former East Germany compared to West Germany after German reunification: A study from the German Childhood Cancer Registry. Cancer Epidemiol. 2021 08; 73:101968. PMID: 34174725.
Lausberg E, Dewulf JP, Wiame E, Salvarinova R, van Karnebeek CD, Klemm P, Ohl K, Mull M, Braunschweig T, Weis J, Sommer CJ, Stollbrink-Peschgens C, Choukair D, Oommen PT, Borkhardt A, Wagner N, Meyer R, Eggermann T, Begemann M, Van Schaftingen E, Tenbrock K, van den Heuvel L, Elbracht M, Kurth I, Kraft F, Gie?elmann S, Holz A, Demuth S, Haase C, Debray FG, Libioulle C, Surowy H, Wieczorek D, H?usler M. C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation. J Clin Invest. 2021 06 15; 131(12). PMID: 33945503; PMCID: PMC8203463.
Bartenhagen C, Attarbaschi A, Classen CF, Kontny U, Wagener R, Taeubner J, Walter C, Yasin L, Alzoubi D, Hauer J, Fischer U, Dugas M, Kuhlen M, Borkhardt A, Brozou T. Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer. Eur J Hum Genet. 2021 08; 29(8):1301-1311. PMID: 33840814; PMCID: PMC8385053.
Yoshimi A, Cario H, Fisch A, Gross-Wieltsch U, Timmermann K, Kontny U, Lobitz S, Schmid I, Uetz B, Borkhardt A, Hohnecker A, Metzler M, Karall D, Niemeyer CM, Gr?nert SC, Odenthal HS, H?ll T, R?tig A, L?cke T, Strau? G. Haematological characteristics and spontaneous haematological recovery in Pearson syndrome. Br J Haematol. 2021 06; 193(6):1283-1287. PMID: 33837965.
Kather JN, Lang KS, Werner J, Kronberg RM, Stachura P, Ostermann PN, M?ller L, Schaal H, Bhatia S, Borkhardt A, Pandyra AA, Lang PA. Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2. Viruses. 2021 04 02; 13(4). PMID: 33918368; PMCID: PMC8066066.
Hansen FK, Pflieger M, S?nnichsen M, Horstick-Muche N, Yang J, Schliehe-Diecks J, Sch?ler A, Borkhardt A, Hamacher A, Kassack MU, Bhatia S, Kurz T. Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity. ChemMedChem. 2021 06 07; 16(11):1798-1803. PMID: 33629513; PMCID: PMC8251746.
Hein D, Borkhardt A, Fischer U. Genomic Inverse PCR for Screening of Preleukemic Cells in Newborns (GIPFEL Technology). Methods Mol Biol. 2021; 2185:113-134. PMID: 33165846.
Nieper P, Pfeiffer P, Holzem A, Kochanek M, Kisis I, Pelzer BW, da Palma Guerreiro A, Riabinska A, Wiederstein J, Deckert M, Frenzel LP, Sander S, Brunn A, Lohneis P, Persigehl T, Peifer M, Knittel G, Klein S, Ryan JA, Klatt AR, Pasqualucci L, Melnick AM, Montesinos-Rongen M, Kashkar H, Letai A, Reinhardt HC, Fl?mann R, Rehk?mper T, Bhatia S, Ahlert H, Hauer J, Reimann M, Kr?ger M, Altm?ller J, B?guelin W, B?ttner R, Borkhardt A, Schmitt CA. An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov. 2021 01; 2(1):70-91. PMID: 33447829; PMCID: PMC7806186.
Alves Avelar LA, Schrenk C, S?nnichsen M, Hamacher A, Hansen FK, Schliehe-Diecks J, Borkhardt A, Bhatia S, Kassack MU, Kurz T. Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors. Eur J Med Chem. 2021 Feb 05; 211:113095. PMID: 33360560.
Niehues T, Bucher M, Endesfelder D, Roessler U, Borkhardt A, D?ckers G, Kirlum HJ, Lankisch P, Oommen PT, R?be CE, Baumgartner I, Bunk F, Moertl S, Hornhardt S, Gomolka M. Analysis of chromosomal aberrations and ?H2A.X foci to identify radiation-sensitive ataxia-telangiectasia patients. Mutat Res Genet Toxicol Environ Mutagen. 2021 Jan-Feb; 861-862:503301. PMID: 33551102.
Jamra RA, Muschke P, Popp B, Zenker M, F?hrenbach M, Borkhardt A, Brozou T, Rey LK, Schaper J, Surowy H, Zweier C, Wieczorek D, Redler S. QRICH1 variants in Ververi-Brady syndrome-delineation of the genotypic and phenotypic spectrum. Clin Genet. 2021 01; 99(1):199-207. PMID: 33009816.
Yang JJ, Ikawa T, Fischer U, Hein D, Vicente-Due?as C, Borkhardt A, S?nchez-Garc?a I. Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and Leukemia. Blood Cancer Discov. 2020 11; 1(3):224-233. PMID: 33392513; PMCID: PMC7774874.
Hauer J, Auer F, Fischer U, Borkhardt A. Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia. Leukemia. 2020 08; 34(8):2217-2219. PMID: 32555367; PMCID: PMC7301049.
Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Alonso MEV, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Conter V, Stary J, Schrappe M, Rives S, Del Pozo Carlavilla M, Dom?nguez-Pinilla N, Escherich G, Lauten M, Ottoffy G, Felice MS, Buldini B. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Eur J Cancer. 2020 06; 132:11-16. PMID: 32305831; PMCID: PMC7141482.
Hein D, Borkhardt A, Fischer U. Insights into the prenatal origin of childhood acute lymphoblastic leukemia. Cancer Metastasis Rev. 2020 03; 39(1):161-171. PMID: 31902036; PMCID: PMC7098935.
Schramm F, Zur Stadt U, Zimmermann M, Jorch N, Pekrun A, Borkhardt A, Imschweiler T, Christiansen H, Schmid I, Feuchtinger T, Beron G, Horstmann MA, Janka-Schaub GE, Escherich G, Faber J, den Boer ML, Pieters R. Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity. Blood Adv. 2019 11 26; 3(22):3688-3699. PMID: 31765480; PMCID: PMC6880907.
Kloetgen A, Borkhardt A, Hoell JI, McHardy AC, M?nch PC. Corrigendum to: Biochemical and bioinformatic methods for elucidating the role of RNA-protein interactions in posttranscriptional regulation. Brief Funct Genomics. 2019 11 19; 18(6):433. PMID: 31169895; PMCID: PMC6920523.
Riabinska A, Lehrmann D, Jachimowicz RD, Knittel G, Fritz C, Schmitt A, Geyer A, Heneweer C, Wittersheim M, Frenzel LP, Torgovnick A, Wiederstein JL, Wunderlich CM, Ortmann M, Paillard A, Burdach S, Hansmann ML, Mall G, Klapper W, Merseburg A, Persigehl T, Wunderlich FT, Peifer M, Beleggia F, Reinhardt HC, W??mann W, Borkhardt A, Rosenwald A, Perner S, Kr?ger M, Gr?ll H, Uterm?hlen O, B?ttner R. ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020 03; 34(3):771-786. PMID: 31690822.
Demir S, Stanulla M, Schrappe M, Zur Stadt U, Bader P, Strahm B, Alten J, Moericke A, Escherich G, Thiele R, McHardy AC, Peters C, Hoell JI, Ginzel S, Kuhlen M, Kloetgen A, Gombert M, Fischer U, Hein D, Babor F, Schuster F, von Stackelberg A, Bornhauser B, Bourquin JP, Krause S, Enczmann J, Meyer LH, Eckert C, Borkhardt A, Meisel R. Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets. Blood Adv. 2019 10 22; 3(20):3143-3156. PMID: 31648313; PMCID: PMC6849953.
Dreisig K, Metzler M, Izraeli S, Schmiegelow K, Hein D, Borkhardt A, Fischer U. The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ?0.6% of healthy newborns. Blood. 2019 10 17; 134(16):1355-1358. PMID: 31434706; PMCID: PMC7005361.
Varon M, Levy T, Mazor G, Ben David H, Marciano R, Krelin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Remke M, Rotblat B, Borkhardt A, Reifenberger G, Leprivier G. The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Int J Cancer. 2019 12 15; 145(12):3402-3413. PMID: 31081944.
Peters C, Glogova E, Sauer M, Cario G, Gruhn B, Horn PA, Kremens B, Mytilineos J, Pichler H, Stachel D, Strahm B, Escherich G, Zimmermann M, Schrappe M, Bader P, Babor F, Manser AR, P?tschger U, Ahlmann M, Feuchtinger T, G?ng?r T, Lang P, Mezger M, M?ller I, Oevermann L, Scherenschlich N, Schuster FR, Siepermann M, W?ssmann W, Borkhardt A, Eckert C, Uhrberg M, Meisel R. Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL. Bone Marrow Transplant. 2019 11; 54(11):1847-1858. PMID: 31089287.
Kohns Vasconcelos M, Laws HJ, Borkhardt A, Neubert J. Medical history and clinical examinations are insufficient to exclude vertical human immunodeficiency virus transmission in healthy, at-risk adolescents. Acta Paediatr. 2019 06; 108(6):994-997. PMID: 30901119.
Nebral K, Ganmore I, Haas OA, Izraeli S, Trka J, Hu J, Lin M, Gertzen CGW, Bhatia S, Fischer U, Kuhlen M, Gohlke H, Borkhardt A, Hauer J, Auer F. JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility. Leukemia. 2019 09; 33(9):2331-2335. PMID: 30967616; PMCID: PMC6756027.
Eiz-Vesper B, G?ssling KL, Fouz H, Kyrillopoulou O, Aubin M, Maecker-Kolhoff B, Adams O, Borkhardt A, Babor F, Schuster FR, Siepermann M, Schumm M, Lang P, Meisel R. Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After a?TCR-CD19-Depleted Stem Cell Transplantation. Clin Infect Dis. 2019 04 08; 68(8):1406-1409. PMID: 30357314.
Mazor G, Levin L, Picard D, Ahmadov U, Remke M, Rotblat B, Car?n H, Borkhardt A, Reifenberger G, Leprivier G. The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Cell Death Dis. 2019 03 13; 10(3):246. PMID: 30867410; PMCID: PMC6416247.
Bomken S, van der Werff Ten Bosch J, Attarbaschi A, Bacon CM, Boztug K, Hauck F, Lammens T, Quinti I, Seidel MG, Warnatz K, Wehr C, Lankester AC, Gennery AR, Borkhardt A, Fischer U, Kuiper RP, Loeffen J, Neven B, Pan-Hammarstr?m Q. Current Understanding and Future Research Priorities in Malignancy Associated With Inborn Errors of Immunity and DNA Repair Disorders: The Perspective of an Interdisciplinary Working Group. Front Immunol. 2018; 9:2912. PMID: 30619276; PMCID: PMC6299915.
Paltiel O, Lemeshow S, Phillips GS, Tikellis G, Linet MS, Ponsonby AL, Magnus P, Olsen SF, Klebanoff M, Golding J, Herceg Z, Ghantous A, Hirst JE, Borkhardt A, Ward MH, Dwyer T, H?berg SE, Granstr?m C, Holst S?egaard S. The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C). Int J Cancer. 2019 01 01; 144(1):26-33. PMID: 30098208.
Martignetti L, Calzone L, Brabetz S, Montagud A, Sta A, Dingli F, Arras G, Rivera J, Loew D, Dufour C, Leboucher S, Sieber L, Chavez L, Okonechnikov K, Sharma T, Thatikonda V, Bourdeaut F, Ramaswamy V, Korshunov A, Poullet P, Taylor MD, Kool M, Pfister SM, Kawauchi D, Barillot E, Forget A, Puget S, Picard D, Liva S, Besnard A, Lacombe J, Pag?s M, Varlet P, Yu H, Mercier AL, Indersie E, Chivet A, Beccaria K, Gombert M, Meyer FD, Qin N, Bartl J, Pouponnot C, Borkhardt A, Reifenberger G, Remke M, Ayrault O. Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell. 2018 09 10; 34(3):379-395.e7. PMID: 30205043.
Bader P, Sauer M, Gruhn B, Kropshofer G, Lawitschka A, Metzler M, Schrappe M, Schrum J, Schulz A, Schwinger W, Strahm B, Poetschger U, Glogova E, Peters C, Kuhlen M, Albert MH, G?ng?r T, Lang P, Pentek F, Rossig C, Schlegel PG, von Stackelberg A, Suttorp M, Luettichau IT, W??mann W, Borkhardt A, Meisel R. Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial. Br J Haematol. 2018 10; 183(1):104-109. PMID: 30028016.
Hoell JI, Warfsmann J, Distelmaier F, Borkhardt A, Kuhlen M, Jan?en G. Challenges of palliative care in children with inborn metabolic diseases. Orphanet J Rare Dis. 2018 07 09; 13(1):112. PMID: 29986738; PMCID: PMC6038293.
Schramm F, Zimmermann M, Jorch N, Pekrun A, Borkhardt A, Christiansen H, Feuchtinger T, Schmid I, Beron G, Horstmann MA, Escherich G, Imschweiler T, Faber J. Daunorubicin during delayed intensification decreases the incidence of infectious complications - a randomized comparison in trial CoALL 08-09. Leuk Lymphoma. 2019 01; 60(1):60-68. PMID: 29966458.
Suttorp M, Schulze P, Glauche I, von Neuhoff N, Metzler M, Sedlacek P, de Bont ESJM, Lausen B, Aleinikova O, Sufliarska S, Kremens B, Berthold F, Klein C, Sykora KW, Kulozik AE, Schrappe M, Nowasz C, Krumbholz M, Tauer JT, Claviez A, Harbott J, Kreipe HH, Schlegelberger B, Thiede C, G?hring G, Balduzzi A, Henze G, Strauss G, Eggert A, Groll AH, Gro?-Wieltsch U, Borkhardt A. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia. 2018 07; 32(7):1657-1669. PMID: 29925908.
Bhatia S, Walter C, Parvin S, Haas O, Woessmann W, Stanulla M, Schrappe M, Dugas M, Natkunam Y, Orfao A, Blanco O, De Las Rivas J, Lossos IS, Borkhardt A, Hauer J, Garc?a-Ram?rez I, Rodr?guez-Hern?ndez G, Gonz?lez-Herrero I, Gonz?lez de Tena-D?vila S, Dom?nguez V, Pintado B, Alonso-L?pez D, Mart?n-Lorenzo A, Jim?nez R, Garc?a Criado FJ, Garc?a Cenador MB, Vicente-Due?as C, S?nchez-Garc?a I. Lmo2 expression defines tumor cell identity during T-cell leukemogenesis. EMBO J. 2018 07 13; 37(14). PMID: 29880602; PMCID: PMC6043907.
Bhatia S, Ahlert H, Stein S, Lang F, Ernst T, Kunkel H, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Hauer J, Diedrich D, Frieg B, Bopp B, Zang T, Kr?ger T, K?gler G, Krieg A, L?deke S, Rodrigues Moita AJ, Kassack MU, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response. Blood. 2018 07 19; 132(3):307-320. PMID: 29724897; PMCID: PMC6225350.
Krull K, Kunstreich M, Bronsema A, Bleckmann K, Classen CF, Erdlenbruch B, Jorch N, Kolb R, Leipold A, Moser O, Prokop A, Steinbach D, Klasen-Sansone J, Klee D, Escherich G, Moericke A, Schrappe M, Borkhardt A, Kuhlen M, Scheurlen W. Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy. Leuk Lymphoma. 2019 01; 60(1):78-84. PMID: 29718744.
Hoell JI, Weber HL, Balzer S, Danneberg M, Gagnon G, Trocan L, Borkhardt A, Kuhlen M, Jan?en G. Advance care planning and outcome in pediatric palliative home care. Oncotarget. 2018 Apr 03; 9(25):17867-17875. PMID: 29707152; PMCID: PMC5915160.
van de Loo K, Balzer S, MacKenzie CR, Boemers TM, Ortmann M, Borkhardt A, Kuhlen M, Schaper J, Laws HJ. Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report. BMC Infect Dis. 2018 03 05; 18(1):105. PMID: 29506484; PMCID: PMC5839039.
Auer F, Chan LN, Bartenhagen C, Dugas M, Gombert M, Ginzel S, Rivas JL, Borkhardt A, Hauer J, Mart?n-Lorenzo A, Garc?a-Ram?rez I, Gonz?lez-Herrero I, Rodr?guez-Hern?ndez G, Blanco O, Orfao A, Alonso-L?pez D, Garc?a-Cenador MB, Garc?a-Criado FJ, M?schen M, S?nchez-Garc?a I, Vicente-Due?as C. Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL. Cancer Res. 2018 05 15; 78(10):2669-2679. PMID: 29490943; PMCID: PMC6245574.
Hain A, Kr?mer M, Linka RM, Nakhaei-Rad S, Ahmadian MR, H?ussinger D, Borkhardt A, M?nk C. IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells. Sci Rep. 2018 02 16; 8(1):3217. PMID: 29453458; PMCID: PMC5816632.
Namineni S, Shaabani N, Trilling M, van Rooijen N, Crocker PR, Tanaka M, Heikenwalder M, Mak TW, Brenner D, Pandyra AA, Lang KS, Shinde PV, Xu HC, Maney SK, Kloetgen A, Zhuang Y, Honke N, Bellora N, Doerrenberg M, Pozdeev VI, Scheu S, Pfeffer K, Duggimpudi S, Knolle P, Ruland J, Hoell JI, Borkhardt A, H?ussinger D, Lang PA. Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J Virol. 2018 02 01; 92(3). PMID: 29142134; PMCID: PMC5774891.
Olsen M, Stanulla M, Slany R, Schmiegelow K, Sch?fer D, L?hnemann D, Borkhardt A, Fischer U. Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening. Blood. 2018 02 15; 131(7):821-826. PMID: 29311095; PMCID: PMC5909885.
Wimmer K, Fauth C, Felsberg J, Riemer J, Taeubner J, Muleris M, Lascols O, Colas C, Brozou T, Gombert M, Ginzel S, Hoell JI, Borkhardt A, Kuhlen M. Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6. Eur J Hum Genet. 2018 03; 26(3):440-444. PMID: 29302048; PMCID: PMC5839041.
Brozou T, Taeubner J, Velleuer E, Dugas M, Wieczorek D, Borkhardt A, Kuhlen M. Correction to: Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES. Eur J Pediatr. 2018 01; 177(1):61. PMID: 29105029; PMCID: PMC6828017.
Kuhlen M, Willasch AM, Wachowiak J, Yaniv I, Ifversen M, Sedlacek P, Lang P, Bader P, Sufliarska S, Strahm B, Hoell JI, Borkhardt A, Klingebiel T, Schrappe M, Glogova E, Poetschger U, Meisel R, Peters C, Dalle JH, Guengoer T, Balduzzi A, von Luettichau I, von Stackelberg A. Outcome of relapse after allogeneic HSCT in children with ALL enrolled in the ALL-SCT 2003/2007 trial. Br J Haematol. 2018 01; 180(1):82-89. PMID: 29193007.
Schmidt E, Fischer U, Biskup W, Haferlach C, Meisel R, Kuhlen M, Borkhardt A. Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome. Klin Padiatr. 2017 11; 229(6):352-354. PMID: 29132167.
Offenmueller S, Classen CF, Corbacioglu S, Dirksen U, Ebetsberger-Dachs G, Heinzerling L, Jorch N, Kuhlen M, Lawlor J, Streiter M, Brecht I, Leiter U, Bernbeck B, Garbe C, Eigentler T, Borkhardt A, Niggli F, Schneider DT. Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP). Klin Padiatr. 2017 Nov; 229(6):322-328. PMID: 29017184.
Kuhlen M, Taeubner J, Wieczorek D, Borkhardt A. Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated? Mol Cell Pediatr. 2017 Oct 05; 4(1):8. PMID: 28983852; PMCID: PMC5629188.
Citations:
Rodr?guez-Hern?ndez G, Sch?fer D, Gavil?n A, Vicente-Due?as C, Hauer J, Borkhardt A, S?nchez-Garc?a I. Modeling the process of childhood ETV6-RUNX1 B-cell leukemias. Oncotarget. 2017 Nov 24; 8(60):102674-102680. PMID: 29254279; PMCID: PMC5731989.
Hoell JI, Warfsmann J, Balzer S, Borkhardt A, Janssen G, Kuhlen M. End-of-life care in children with hematologic malignancies. Oncotarget. 2017 Oct 27; 8(52):89939-89948. PMID: 29163800; PMCID: PMC5685721.
Brozou T, Taeubner J, Velleuer E, Dugas M, Wieczorek D, Borkhardt A, Kuhlen M. Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES. Eur J Pediatr. 2018 Jan; 177(1):53-60. PMID: 28929227; PMCID: PMC5748429.
Hoell JI, Warfsmann J, Gagnon G, Trocan L, Balzer S, Oommen PT, Borkhardt A, Kuhlen M, Jan?en G. Palliative care for children with a yet undiagnosed syndrome. Eur J Pediatr. 2017 Oct; 176(10):1319-1327. PMID: 28808789.
Hansson N, Oommen-Halbach A, Borkhardt A, Fangerau H. Nobel Prize nominees hundred years ago: Abraham Jacobi (1830-1919) and Otto Heubner (1843-1926). Eur J Pediatr. 2017 Oct; 176(10):1411-1413. PMID: 28804857.
Kuhlen M, Bleckmann K, Schrappe M, Vieth S, Escherich G, Bronsema A, Vonalt A, Queudeville M, Zwaan CM, Ebinger M, Debatin KM, Klingebiel T, Koscielniak E, Rossig C, Burkhardt B, Kolb R, Borkhardt A, M?ricke A, Eckert C, von Stackelberg A, Chen-Santel C. Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy. Br J Haematol. 2017 10; 179(2):272-283. PMID: 28771662.
Michalsky N, Borkhardt A, Neubert J, Laws HJ, Jensen B, L?bke N. HIV-1 Subtype Diversity and Prevalence of Primary Drug Resistance in a Single-Center Pediatric Cohort in Germany. Intervirology. 2016; 59(5-6):301-306. PMID: 28675900.
Amberger DC, Doraneh-Gard F, Sutanto W, Guenther T, Schmohl J, Schuster F, Salih H, Babor F, Borkhardt A, Schmetzer H, Boeck CL. Significance of Frequencies, Compositions, and/or Antileukemic Activity of (DC-stimulated) Invariant NKT, NK and CIK Cells on the Outcome of Patients With AML, ALL and CLL. J Immunother. 2017 Jul/Aug; 40(6):224-248. PMID: 28557814.
Fremerey J, Balzer S, Brozou T, Schaper J, Borkhardt A, Kuhlen M. Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome. Fam Cancer. 2017 07; 16(3):401-405. PMID: 27896549.
Bartenhagen C, Dugas M, Blanco O, De Las Rivas J, Rodr?guez-Hern?ndez G, Hauer J, Mart?n-Lorenzo A, Sch?fer D, Garc?a-Ram?rez I, Auer F, Gonz?lez-Herrero I, Ruiz-Roca L, Gombert M, Okpanyi V, Fischer U, Chen C, Bhatia S, Linka RM, Garcia-Suquia M, Rasc?n-Trincado MV, Garcia-Sanchez A, Garc?a-Cenador MB, Garc?a-Criado FJ, Cobaleda C, Alonso-L?pez D, M?schen M, Vicente-Due?as C, S?nchez-Garc?a I, Borkhardt A. Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases. Cancer Res. 2017 08 15; 77(16):4365-4377. PMID: 28630052.
Kuhlen M, Kunstreich M, Krull K, Meisel R, Borkhardt A. Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge. Blood Adv. 2017 Jun 13; 1(14):981-994. PMID: 29296741; PMCID: PMC5737600.
Schwartzman O, Savino AM, Gombert M, Cario G, Schrappe M, Huang JY, Hameiri-Grossman M, Avigad S, Te Kronnie G, Geron I, Birger Y, Rein A, Zarfati G, Fischer U, Mukamel Z, Stanulla M, Vetere A, Wagner BK, Chen Z, Chen SJ, Tanay A, Borkhardt A, Izraeli S, Palmi C, Eckert C, von Stackelberg A, Biondi A, Cazzaniga G. Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4030-E4039. PMID: 28461505; PMCID: PMC5441776.
van den Bruck R, Weil PP, Vogel S, Schuster F, Orth V, Pembaur D, Zirngibl H, Wirth S, Jenke ACW, Postberg J, Boy N, Heringer J, Haege G, Glahn EM, Hoffmann GF, Garbade SF, Burgard P, Staufner C, Hoffmann GF, Seeliger S, Hippe A, Zierk J, Arzideh F, Rascher W, Rauh M, Metzler M, Thieme S, Bandola J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Hedrich CM, Bonifacio E, Berner R, Brenner S, Hammersen J, Has C, Naumann-Bartsch N, Stachel D, Kiritsi D, Metzler M, Bruckner-Tuderman L, Schneider H, Bohne F, Langer D, Cencic R, Eggermann T, Zechner U, Pelletier J, Zepp F, Enklaar T, Prawitt D, Heinsen FA, Franke A, Happle C, Dittrich AM, Hansen G, Fuchs O, von Mutius E, Oliver BG, Paret C, Russo A, Theruvath J, Keller B, El Malki K, Lehmann N, Wingerter A, Neu MA, Aslihan GA, Wagner W, Sommer C, Pietsch T, Seidmann L, Schreiner F, Ackermann M, Michalik M, Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Zimmer A, Woelfle J, Hagenbuchner J, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ, Loges NT, Frommer AT, Wallmeier J, Omran H, Nemes K, Siebert R, Kool M, Hardy H, Refai O, Barwick KES, Zimmerman HH, Baple EL, Crosby AH, Liebau MC, Tews D, Wabitsch M, Fischer-Posovszky P, Westhoff MA, Nonnenmacher L, Langhans J, Schneele L, Trenkler N, Debatin KM, Ziegenhals T, Schreiner P, Juranek S, G?dde D, D?rner J, R?per M, St?rkel S, K?lker S, Chao CM, Yahya F, Moiseenko A, Shrestha A, Ahmadvand N, Quantius J, Wilhelm J, El-Agha E, Zimmer KP, Bellusci S, K?lker S, Prokisch H, M?ller M, Steinkraus H, Wauer R, Lachmann B, Hofmann SR, Hedrich CM, Haeckel R, S?der S, Tardieu M, Pech M, Weckmann M, Kopp MV, Faber J, D?tsch J, Fischer HS, Ullrich TL, B?hrer C, Czernik C, Schmalisch G, Stein R, ?ner-Sieben S, Gimpfl M, Rozman J, Irmler M, Beckers J, De Angelis MH, Roscher A, Wolf E, Ensenauer R, Fr?hwald M, Hasselblatt M, Kordes U, Wang H, Weis J, Cirak S, Hellmuth C, Uhl O, Standl M, Heinrich J, Thiering E, Koletzko B, Bl?mel L, Kerl K, Picard D, Fr?hwald MC, Reifenberger G, Borkhardt A, Hasselblatt M, Remke M. Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016. Mol Cell Pediatr. 2017 May; 4(Suppl 1):5. PMID: 28516419; PMCID: PMC5435609.
Citations:
Kunstreich M, Kreth JH, Oommen PT, Schaper J, Karenfort M, Aktas O, Tibussek D, Distelmaier F, Borkhardt A, Kuhlen M. Paraneoplastic limbic encephalitis with SOX1 and PCA2 antibodies and relapsing neurological symptoms in an adolescent with Hodgkin lymphoma. Eur J Paediatr Neurol. 2017 Jul; 21(4):661-665. PMID: 28389060.
Ripperger T, Bielack SS, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Dirksen U, Erlacher M, Fleischhack G, Gnekow A, Goehring G, Graf N, Hero B, Hettmer S, von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler R, Kerl K, Klingebiel T, Kontny U, Kordes U, Koscielniak E, Kramm CM, Kulozik AE, Lamottke B, Leuschner I, Lohmann DR, Meinhardt A, Metzler M, Moser O, Nathrath M, Niemeyer CM, Nustede R, Pajtler KW, Paret C, Rasche M, Reinhardt D, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, von Bueren AO, Vorwerk P, Witt O, Wlodarski M, Zenker M, Zimmermann S, Pfister SM, Kratz CP, Borkhardt A, Deubzer H, Eckert C, Eggert A, Fr?hwald MC, Hanenberg H, Hauer J, K?rholz D, Kuhlen M, Meyer LH, Rie? O, W?ssmann W. Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. Am J Med Genet A. 2017 Apr; 173(4):1017-1037. PMID: 28168833.
Korn K, Pfister SM, Rinaldi A, Bourquin JP, Hu J, Ensser A, Bartenhagen C, Fischer U, Gombert M, Chen C, Okpanyi V, Hauer J, Eckert C, Dugas M, Borkhardt A. Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing. Haematologica. 2017 05; 102(5):e179-e183. PMID: 28154091; PMCID: PMC5685284.
Krull K, Kunstreich M, Klasen-Sansone J, Kloetgen A, Gruener F, Escherich G, Bleckmann K, Moericke A, Schrappe M, Jorch N, Steinbach D, Classen CF, Guggemos A, Kolb R, Klee D, Borkhardt A, Kuhlen M. Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial. Leuk Lymphoma. 2017 Oct; 58(10):2363-2369. PMID: 28140726.
Kempkes B, Klapper W, Niehues T, Schneider D, Speckmann C, Ghosh S, H?nscheid A, D?ckers G, Ginzel S, Gohlke H, Gombert M, Kuhlen M, Laws HJ, Linka RM, Meisel R, Mielke C, Schindler D, Schuster FR, Borkhardt A. Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency. Haematologica. 2017 02; 102(2):e69-e72. PMID: 27979922; PMCID: PMC5286958.
von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L. Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia. J Clin Oncol. 2016 12 20; 34(36):4381-4389. PMID: 27998223.
Kloetgen A, Borkhardt A, Hoell JI, McHardy AC. The PARA-suite: PAR-CLIP specific sequence read simulation and processing. PeerJ. 2016; 4:e2619. PMID: 27812418; PMCID: PMC5088580.
Bleckmann K, Stanulla M, Schrappe M, McHardy AC, Doerrenberg M, Kloetgen A, Hezaveh K, W?ssmann W, Borkhardt A, Hoell JI. T-cell acute lymphoblastic leukemia in infants has distinct genetic and epigenetic features compared to childhood cases. Genes Chromosomes Cancer. 2017 02; 56(2):159-167. PMID: 27717083.
Kunstreich M, Kummer S, Laws HJ, Borkhardt A, Kuhlen M. Osteonecrosis in children with acute lymphoblastic leukemia. Haematologica. 2016 11; 101(11):1295-1305. PMID: 27742768; PMCID: PMC5394877.
Bhatia S, Daschkey S, Lang F, Borkhardt A, Hauer J. Mouse models for pre-clinical drug testing in leukemia. Expert Opin Drug Discov. 2016 Nov; 11(11):1081-1091. PMID: 27562952.
Kuhlen M, Hoell JI, Gagnon G, Balzer S, Oommen PT, Borkhardt A, Jan?en G. Effective treatment of spasticity using dronabinol in pediatric palliative care. Eur J Paediatr Neurol. 2016 Nov; 20(6):898-903. PMID: 27506815.
Worst BC, van Tilburg CM, Balasubramanian GP, Fiesel P, Witt R, Freitag A, Boudalil M, Previti C, Wolf S, Schmidt S, Chotewutmontri S, Bewerunge-Hudler M, Schick M, Schlesner M, Hutter B, Taylor L, Borst T, Sutter C, Bartram CR, Milde T, Pfaff E, Kulozik AE, Reinhardt D, Klusmann JH, Fleischhack G, Tippelt S, Westermann F, Fischer M, Bielack SS, Fulda S, Klingebiel T, Koscielniak E, Brors B, von Deimling A, Lichter P, Capper D, Pfister SM, Jones DT, Witt O, von Stackelberg A, Meisel R, Borkhardt A, Dirksen U, J?rgens H, Kramm CM, von Bueren AO, Burkhardt B, W??mann W, Nathrath M, Fr?hwald MC, Schwab M, Tremmel R, Driever PH, Schulte JH, Eggert A. Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur J Cancer. 2016 09; 65:91-101. PMID: 27479119.
Simanovsky N, Kfir-Erenfeld S, Assayag-Asherie N, Revel-Vilk S, Yefenof E, Stepensky P, Schipp C, Nabhani S, Bienemann K, Oommen PT, H?nscheid A, Gombert M, Ginzel S, Sch?fer D, Laws HJ, Fleckenstein B, Borkhardt A, Fischer U. Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans. Haematologica. 2016 10; 101(10):e392-e396. PMID: 27365489; PMCID: PMC5046658.
Thiele R, Joosten M, Ginzel S, Blex C, Schmidt D, Gombert M, Chen C, Linka RM, Gr?bner O, Hain A, Hirsch B, Sommerfeld A, Seegebarth A, Gruber U, Maneck C, Zhang L, Stenin K, Dieks H, Sefkow M, M?nk C, Baldus CD, Borkhardt A, Hummel M, K?ster H, Fischer U, Dreger M, Seitz V. A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma. Mol Oncol. 2016 10; 10(8):1232-44. PMID: 27324824; PMCID: PMC5423193.
Alawi M, Kutsche K, Vogel M, Velleuer E, Schmidt-Jim?nez LF, Mayatepek E, Borkhardt A, Kort?m F. Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis. Am J Med Genet A. 2016 07; 170(7):1813-9. PMID: 27144914.
Schwabe D, Klingebiel T, Bienemann K, Daschkey S, S?rensen J, H?nscheid A, Gombert M, Ginzel S, Borkhardt A. A novel homozygous mutation in UNC13D presenting as Epstein-Barr-virus-associated lymphoproliferative disease at 9?years of age. Leuk Lymphoma. 2016 12; 57(12):2949-2951. PMID: 27123661.
Dasenbrock C, Ravazzani P, Erdmann F, Fedrowitz M, Hamnerius Y, Sanchez-Garcia I, Seger R, Schmiegelow K, Ziegelberger G, Manser M, Schmid CD, Struchen B, Sch?z J, R??sli M, Sch?r P, Bounds PL, Borkhardt A, Cobaleda C, Capstick M, M?ller M, Sch?rmann D, Kuster N. Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium. Bioelectromagnetics. 2016 Apr; 37(3):183-189. PMID: 26991812.
Kuhlen M, Hoell J, Balzer S, Borkhardt A, Janssen G. Symptoms and management of pediatric patients with incurable brain tumors in palliative home care. Eur J Paediatr Neurol. 2016 Mar; 20(2):261-269. PMID: 26753538.
Kuhlen M, Schemme J, Merz H, Borkhardt A, Troeger A, H?nscheid A, Mauz-K?rholz C. Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome. Eur J Pediatr. 2016 Apr; 175(4):593-7. PMID: 26526666.
Kuhlen M, Loizou L, Nabhani S, Fischer U, Stepensky P, Klapper W, Siepermann M, Schuster F, Meisel R, Borkhardt A, H?nscheid A, Schaper J. De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly. Clin Immunol. 2016 Jan; 162:27-30. PMID: 26529633.
Kuhlen M, Sabir H, Borkhardt A, H?ll JI, Jan?en G. Experiences in palliative home care of infants with life-limiting conditions. Eur J Pediatr. 2016 Mar; 175(3):321-7. PMID: 26411975.
Hauer J, Auer F, Ginzel S, Thiele R, Bartenhagen C, Dugas M, Gombert M, Rivas Jde L, Borkhardt A, Mart?n-Lorenzo A, Vicente-Due?as C, Gonz?lez-Herrero I, Garc?a-Ram?rez I, Constantinescu SN, Sch?fer D, Blanco O, Mayado A, Orfao A, Alonso-L?pez D, Cobaleda C, Garc?a-Cenador MB, Garc?a-Criado FJ, S?nchez-Garc?a I. Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility. Cancer Discov. 2015 Dec; 5(12):1328-43. PMID: 26408659.
Doose G, Haake A, Bernhart SH, Wojciech F, Bergmann AK, Claviez A, Karsch D, Klapper W, Kretzmer H, Kreuz M, Lawerenz C, Loeffler M, Ott G, Richter J, Rohde M, Rosenstiel P, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Weniger MA, ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I, L?pez C, Duggimpudi S, Borkhardt A, Burkhardt B, Dimitrova L, Haas S, Hoell JI, Hummel M, Kleo K, K?ppers R, Lenze D, Mantovani-L?ffler L, M?ller P, Rosenwald A, Tr?mper L. MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5261-70. PMID: 26351698; PMCID: PMC4586867.
Troeger A, Koster KL, Laws HJ, Meisel R, Borkhardt A, Oommen PT. Visceral Leishmaniasis as a Possible Reason for Pancytopenia. Front Pediatr. 2015; 3:59. PMID: 26176005; PMCID: PMC4483513.
Bhatia S, Reister S, Mahotka C, Meisel R, Borkhardt A, Grinstein E. Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin. Leukemia. 2015 Nov; 29(11):2208-20. PMID: 26183533.
Laehnemann D, Borkhardt A, McHardy AC. Denoising DNA deep sequencing data-high-throughput sequencing errors and their correction. Brief Bioinform. 2016 Jan; 17(1):154-79. PMID: 26026159; PMCID: PMC4719071.
Kuhlen M, Borkhardt A. Cancer susceptibility syndromes in children in the area of broad clinical use of massive parallel sequencing. Eur J Pediatr. 2015 Aug; 174(8):987-97. PMID: 25982339; PMCID: PMC4516864.
Bienemann K, Borkhardt A, Klapper W, Oschlies I. High incidence of Epstein-Barr virus (EBV)-positive Hodgkin lymphoma and Hodgkin lymphoma-like B-cell lymphoproliferations with EBV latency profile 2 in children with interleukin-2-inducible T-cell kinase deficiency. Histopathology. 2015 Nov; 67(5):607-16. PMID: 25728094.
Kuhlen M, Balzer S, Friedland C, Borkhardt A, Jan?en G. Critical Situations in Children, Adolescents and Young Adults with Terminal Cancer within the Home Setting. Klin Padiatr. 2015 May; 227(3):137-43. PMID: 25811741.
Duggimpudi S, Larsson E, Nabhani S, Borkhardt A, Hoell JI. The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS. PLoS One. 2015; 10(3):e0119066. PMID: 25751255; PMCID: PMC4353705.
Lankisch P, Schiffner J, Ghosh S, Babor F, Borkhardt A, Laws HJ. The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules? J Clin Immunol. 2015 Apr; 35(3):273-9. PMID: 25749910.
Mohammadinejad P, Abolhassani H, Aghamohammadi A, Pourhamdi S, Ghosh S, Sadeghi B, Nasiri Kalmarzi R, Durandy A, Borkhardt A. Class switch recombination process in ataxia telangiectasia patients with elevated serum levels of IgM. J Immunoassay Immunochem. 2015; 36(1):16-26. PMID: 24568663.
Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Lindhofer H, Borkhardt A, Buhmann R, Hess J. Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. Br J Haematol. 2015 Apr; 169(1):90-102. PMID: 25495919.
Hoell JI, Gombert M, Ginzel S, Loth S, Landgraf P, Streiter M, Prokop A, Weiss M, Thiele R, Borkhardt A, K?fer V. Constitutional mismatch repair-deficiency and whole-exome sequencing as the means of the rapid detection of the causative MSH6 defect. Klin Padiatr. 2014 Nov; 226(6-7):357-61. PMID: 25431869.
Fleckenstein B, Nabhani S, H?nscheid A, Oommen PT, Schaper J, Kuhlen M, Laws HJ, Borkhardt A, Fischer U. A novel homozygous Fas ligand mutation leads to early protein truncation, abrogation of death receptor and reverse signaling and a severe form of the autoimmune lymphoproliferative syndrome. Clin Immunol. 2014 Dec; 155(2):231-7. PMID: 25451160.
Chazara O, Moffett A, Babor F, Manser AR, Fischer JC, Scherenschlich N, Enczmann J, Borkhardt A, Meisel R, Uhrberg M. KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse. Blood. 2014 Oct 02; 124(14):2248-51. PMID: 25163702.
Fueller E, Stanulla M, Slany RK, Schaefer D, Fischer U, Krell PF, Borkhardt A. Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia. PLoS One. 2014; 9(8):e104419. PMID: 25137060; PMCID: PMC4138100.
Binder V, Bartenhagen C, Okpanyi V, Gombert M, Moehlendick B, Behrens B, Klein HU, Rieder H, Ida Krell PF, Dugas M, Stoecklein NH, Borkhardt A. A new workflow for whole-genome sequencing of single human cells. Hum Mutat. 2014 Oct; 35(10):1260-70. PMID: 25066732.
Serwas NK, Cagdas D, Ban SA, Salzer E, Tezcan I, Sanal O, Boztug K, Bienemann K, Borkhardt A. Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia. Blood. 2014 Jul 24; 124(4):655-7. PMID: 25061172; PMCID: PMC4110665.
Rohde M, Richter J, Schlesner M, Betts MJ, Claviez A, Bonn BR, Zimmermann M, Damm-Welk C, Russell RB, Borkhardt A, Eils R, Hoell JI, Szczepanowski M, Oschlies I, Klapper W, Burkhardt B, Siebert R, German ICGC MMML-Seq-Project, NHL-BFM Study Group. Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols. Genes Chromosomes Cancer. 2014 Nov; 53(11):911-6. PMID: 25044415.
Kloetgen A, Borkhardt A, Hoell JI, McHardy AC, M?nch PC. Biochemical and bioinformatic methods for elucidating the role of RNA-protein interactions in posttranscriptional regulation. Brief Funct Genomics. 2015 Mar; 14(2):102-14. PMID: 24951655; PMCID: PMC4471435.
Linka Y, Ginzel S, Borkhardt A, Landgraf P. Identification of TEL-AML1 (ETV6-RUNX1) associated DNA and its impact on mRNA and protein output using ChIP, mRNA expression arrays and SILAC. Genom Data. 2014 Dec; 2:85-8. PMID: 26484077; PMCID: PMC4536161.
Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Ryzhova M, Ralser M, Brun S, Bunt J, Kleinheinz K, Erkek S, Weber UD, Bartholomae CC, von Kalle C, Lawerenz C, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Taylor MD, Brors B, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P, Stachurski K, Warnatz HJ, J?ger N, Eils J, Scheurlen W, Felsberg J, Reifenberger G, Borkhardt A, Landgraf P. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 2014 Jun 26; 510(7506):537-41. PMID: 24847876.
Kuhlen M, Moldovan A, Krull K, Meisel R, Borkhardt A. Osteonecrosis in paediatric patients with acute lymphoblastic leukaemia treated on Co-ALL-07-03 trial: a single centre analysis. Klin Padiatr. 2014 May; 226(3):154-60. PMID: 24710762.
Ghosh S, Schuster FR, Adams O, Babor F, Borkhardt A, Comoli P, Handgretinger R, Lang P, Siepermann M, Meisel R, Laws HJ. Haploidentical stem cell transplantation in DOCK8 deficiency - Successful control of pre-existing severe viremia with a TCRa?/CD19-depleted graft and antiviral treatment. Clin Immunol. 2014 May-Jun; 152(1-2):111-4. PMID: 24667686.
Sczyrba A, Dietrich R, Gerlach W, Stoye J, Henrich B, Rumming M, Velleuer E, Gombert M, Rahn S, Borkhardt A, Fischer U. Mycoplasma salivarium as a dominant coloniser of Fanconi anaemia associated oral carcinoma. PLoS One. 2014; 9(3):e92297. PMID: 24642836; PMCID: PMC3958540.
Laws HJ, Adams O, Feiterna-Sperling C, Notheis G, Buchholz B, Borkhardt A, Neubert J, Asang C, Enczmann J. HIV-1 seroreversion in HIV-1-infected children: do genetic determinants play a role? AIDS. 2014 Feb 20; 28(4):543-7. PMID: 24056069.
Vicente-Due?as C, Hauer J, Ruiz-Roca L, Ingenhag D, Rodr?guez-Meira A, Auer F, Borkhardt A, S?nchez-Garc?a I. Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy. Semin Cancer Biol. 2015 Jun; 32:3-9. PMID: 24530939.
Hauer J, Borkhardt A, S?nchez-Garc?a I, Cobaleda C. Genetically engineered mouse models of human B-cell precursor leukemias. Cell Cycle. 2014; 13(18):2836-46. PMID: 25486471; PMCID: PMC4613455.
Izraeli S, Harit M, Weintraub M, Weinstein OY, Lerer I, Stepensky P, Auer F, R?schendorf F, Gombert M, Husemann P, Ginzel S, Borkhardt A, Hauer J. Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A. Leukemia. 2014 May; 28(5):1136-8. PMID: 24287434.
Linka Y, Ginzel S, Novosel A, Gombert M, Kremmer E, Harbott J, Thiele R, Borkhardt A, Landgraf P, Kr?ger M. The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. Blood Cancer J. 2013 Oct 11; 3:e151. PMID: 24121163; PMCID: PMC3816209.
Lankisch P, Borkhardt A, H?nscheid A, Schaper J, Laws HJ. COL2A1 mutation as a cause of premature osteoarthritis in a 13-year-old child. Joint Bone Spine. 2014 Jan; 81(1):83-5. PMID: 23928235.
Seeger K, Hagedorn N, Mann G, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Escherich G, Sramkova L, Niggli F, Hitzler J, von Stackelberg A, Eckert C, Henze G, Panzer-Gr?mayer R, Schrauder A. Use of allogeneic hematopoietic stem-cell transplantation based on minimal residual disease response improves outcomes for children with relapsed acute lymphoblastic leukemia in the intermediate-risk group. J Clin Oncol. 2013 Jul 20; 31(21):2736-42. PMID: 23775972.
Stepensky P, Saada A, Cowan M, Tabib A, Fischer U, Berkun Y, Saleh H, Simanovsky N, Kogot-Levin A, Weintraub M, Ganaiem H, Shaag A, Zenvirt S, Borkhardt A, Elpeleg O, Bryant NJ, Mevorach D. The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy. Blood. 2013 Jun 20; 121(25):5078-87. PMID: 23599270.
Bartenhagen C, Gombert M, Okpanyi V, Binder V, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A, Chen C, R?ttgers S. Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia. Genes Chromosomes Cancer. 2013 Jun; 52(6):564-79. PMID: 23508829.
Lankisch P, Adler H, Borkhardt A. Testing for herpesvirus infection is essential in children with chromosomal-instability syndromes. J Virol. 2013 Mar; 87(6):3616-7. PMID: 23436901; PMCID: PMC3592146.
Giri A, Bradtke J, Teigler-Schlegel A, Meister G, Borkhardt A, Landgraf P, Daschkey S, R?ttgers S. MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways. PLoS One. 2013; 8(2):e56334. PMID: 23418555; PMCID: PMC3572007.
Pfeffer M, Borkhardt A, Niehues T, Adams O, Bolten M, Reuter S, Stannigel H, Laws HJ, Neubert J. Risk adapted transmission prophylaxis to prevent vertical HIV-1 transmission: effectiveness and safety of an abbreviated regimen of postnatal oral zidovudine. BMC Pregnancy Childbirth. 2013 Jan 24; 13:22. PMID: 23347580; PMCID: PMC3568057.
von Stackelberg A, Seeger K, Groeneveld TW, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Escherich G, Eckert C, Henze G. Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed acute lymphoblastic leukaemia - long-term results of trial ALL-REZ BFM P95/96. Eur J Cancer. 2013 Apr; 49(6):1346-55. PMID: 23265714.
Babor F, Manser A, Borkhardt A, Meisel R, Uhrberg M, Sch?nberg K, Enczmann J. Lack of association between KIR genes and acute lymphoblastic leukemia in children. Blood. 2012 Sep 27; 120(13):2770-2; author reply 2772. PMID: 23019206.
Adams O, Schuster FR, Borkhardt A, Meisel R, Ghosh S. Efficient control of pandemic 2009 H1N1 virus infection with intravenous zanamivir despite the lack of immune function. Transpl Infect Dis. 2012 Dec; 14(6):657-9. PMID: 23013415.
Borkhardt A, Chomienne C, Fibbe WE, Hagenbeek A, Skoda RC, Smand CR, de Wit TD, D?hner H, Fo? R, J?ger U. Raising hematology's European voice: the importance of calling yourself a hematologist. Haematologica. 2012 Apr; 97(4):476-8. PMID: 22492289; PMCID: PMC3347677.
Ruckert C, Hubner B, Eckermann O, Binder V, Bakchoul T, Schuster FR, Merk S, Klein HU, Dugas M, Borkhardt A, Fischer U, F?hrer M. CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL. Haematologica. 2012 Sep; 97(9):1304-11. PMID: 22315490; PMCID: PMC3436230.
Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A, K?hrer K. Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases. Leukemia. 2012 May; 26(5):963-71. PMID: 22289921.
Hoell JI, Larsson E, Runge S, Nusbaum JD, Duggimpudi S, Farazi TA, Hafner M, Borkhardt A, Sander C, Tuschl T. RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1428-31. PMID: 22081015; PMCID: PMC3230689.
Kuhlen M, Schneider K, Richter U, Borkhardt A, Janssen G. Palliative sedation in 2 children with terminal cancer - an effective treatment of last resort in a home care setting. Klin Padiatr. 2011 Nov; 223(6):374-5. PMID: 22052636.
Bienemann K, Iouannidou K, Schoenberg K, Krux F, Reuther S, Feyen O, Bienemann K, Schuster F, Uhrberg M, Laws HJ, Borkhardt A. iNKT cell frequency in peripheral blood of Caucasian children and adolescent: the absolute iNKT cell count is stable from birth to adulthood. Scand J Immunol. 2011 Oct; 74(4):406-11. PMID: 21671972.
Burkhardt B, Modlich S, Meyer U, Bienemann K, Escherich G, Zimmermann M, Janka-Schaub G, Schrappe M, Reiter A, Borkhardt A, Bienemann K, M?ricke A, Mauz-K?rholz C, K?rholz D. Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): a retrospective survey. Br J Haematol. 2011 Nov; 155(4):468-76. PMID: 21923652.
Neubert J, Niehues T, Adams O, Morali-Karzei N, Borkhardt A, Laws HJ, Ghosh S. Induction maintenance concept for HAART as initial treatment in HIV infected infants. Eur J Med Res. 2011 Jun 21; 16(6):243-8. PMID: 21810557; PMCID: PMC3353398.
Mullighan C, Morillon E, Wang G, Bruneau J, Brousse N, Lelorc'h M, Romana S, Boudil A, Tiedau D, Kracker S, Bushmann FD, Borkhardt A, Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Hauer J. Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia. Blood. 2011 Jul 21; 118(3):544-53. PMID: 21622646; PMCID: PMC3142899.
Mahotka C, Borkhardt A, Grinstein E. Rb and nucleolin antagonize in controlling human CD34 gene expression. Cell Signal. 2011 Aug; 23(8):1358-65. PMID: 21440621.
Simon T, Berthold F, Borkhardt A, Kremens B, De Carolis B, Hero B. Treatment and outcomes of patients with relapsed, high-risk neuroblastoma: results of German trials. Pediatr Blood Cancer. 2011 Apr; 56(4):578-83. PMID: 21298742.
Sarikaya-Seiwert S, Borkhardt A, Gierga K, Turowski B, Heiroth HJ, Steiger HJ, Stummer W, Eicker S. ALA-induced porphyrin accumulation in medulloblastoma and its use for fluorescence-guided surgery. Cent Eur Neurosurg. 2011 May; 72(2):101-3. PMID: 20931449.
Neubert J, Enczmann J, Krux F, Hower M, Borkhardt A, Laws HJ. Dizygotic twins discordant for HIV-1 despite vertical transmission prophylaxis: was human leukocyte antigen homozygosity of disadvantage to the infected twin? AIDS. 2010 Sep 10; 24(14):2295-6. PMID: 20736685.
Schuster FR, Pierstorff K, Karenfort M, Laws HJ, Borkhardt A, Saleh A, Miese FR. Magnetization transfer imaging provides no evidence of demyelination in methotrexate-induced encephalopathy. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):E110-2. PMID: 20651019; PMCID: PMC8013136.
Burkhardt B, Zimmermann M, Borkhardt A, Kontny U, Klingebiel T, Berthold F, Janka-Schaub G, Klein C, Kabickova E, Klapper W, Attarbaschi A, Schrappe M, Reiter A, Meinhardt A, Berlin-Frankfurt-M?nster group. Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J Clin Oncol. 2010 Jul 01; 28(19):3115-21. PMID: 20516455.
Neubert J, Laws HJ, Adams O, Niehues T, Korn K, Fleckenstein B, Petri E, Borkhardt A, M?nk C, Kr?mer M. HIV-1 seroreversion following antiretroviral therapy in an HIV-infected child initially presenting with acquired immunodeficiency syndrome. AIDS. 2010 Jan 16; 24(2):327-8. PMID: 20029271.
Hertzberg L, Vendramini E, Ganmore I, Cazzaniga G, Schmitz M, Chalker J, Shiloh R, Iacobucci I, Shochat C, Zeligson S, Cario G, Stanulla M, Strehl S, Russell LJ, Harrison CJ, Bornhauser B, Yoda A, Rechavi G, Bercovich D, Borkhardt A, Kempski H, te Kronnie G, Bourquin JP, Domany E, Izraeli S. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood. 2010 Feb 04; 115(5):1006-17. PMID: 19965641.
Balzer S, Richter U, Fritsche-Kansy M, Friedland C, Borkhardt A, Janssen G, Kuhlen M. [Development of a specialised paediatric palliative home care service]. Klin Padiatr. 2009 May-Jun; 221(3):186-92. PMID: 19437372.
Bader P, Kreyenberg H, Eckert C, Reising M, Willasch A, Barth A, Borkhardt A, Peters C, Handgretinger R, Sykora KW, Holter W, Kabisch H, Klingebiel T, von Stackelberg A, ALL-REZ BFM Study Group, Henze GH. Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J Clin Oncol. 2009 Jan 20; 27(3):377-84. PMID: 19064980.
Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, Elimelech A, Shochat C, Cazzaniga G, Biondi A, Basso G, Cario G, Schrappe M, Stanulla M, Strehl S, Haas OA, Mann G, Binder V, Borkhardt A, Kempski H, Trka J, Bielorei B, Avigad S, Stark B, Smith O, Dastugue N, Bourquin JP, Tal NB, Green AR, Izraeli S. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet. 2008 Oct 25; 372(9648):1484-92. PMID: 18805579.
Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, Clappier E, Caccavelli L, Delabesse E, Beldjord K, Asnafi V, MacIntyre E, Dal Cortivo L, Radford I, Brousse N, Moshous D, Hauer J, Borkhardt A, Belohradsky BH, Wintergerst U, Velez MC, Leiva L, Sorensen R, Wulffraat N, Bushman FD, Fischer A, Cavazzana-Calvo M, Hacein-Bey-Abina S, Sigaux F, Blanche S. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008 Sep; 118(9):3132-42. PMID: 18688285; PMCID: PMC2496963.
Schuetz C, Huck K, Gudowius S, Megahed M, Feyen O, Hubner B, Schneider DT, Manfras B, Pannicke U, Willemze R, Schulz A, Borkhardt A, Friedrich W, Schwarz K, Niehues T, Kn?chel R, G?bel U. An immunodeficiency disease with RAG mutations and granulomas. N Engl J Med. 2008 May 08; 358(19):2030-8. PMID: 18463379.
Hauer J, Tosi S, Schuster FR, Harbott J, Kolb HJ, Borkhardt A. Graft versus leukemia effect after haploidentical HSCT in a MLL-negative infant AML with HLXB9/ETV6 rearrangement. Pediatr Blood Cancer. 2008 Apr; 50(4):921-3. PMID: 17960638.
Busch DH, Eppinger E, Kremmer E, Milosevic S, Hennard C, Kuttler C, Ellwart JW, Frankenberger B, Salat C, Bogner C, Borkhardt A, Kolb HJ, Krackhardt AM, Schuster IG, N?ssner E. Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies. Blood. 2007 Oct 15; 110(8):2931-9. PMID: 17626842.
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Schliwka J, Fuchs U, Novosel A, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T, Pfeffer S, Fo? R, M?ller RU. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007 Jun 29; 129(7):1401-14. PMID: 17604727; PMCID: PMC2681231.
Busch K, Keller T, Fuchs U, Yeh RF, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A, Borkhardt A. Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma. Leukemia. 2007 Aug; 21(8):1739-51. PMID: 17541401.
Attarbaschi A, Mann G, Steiner M, Strehl S, Schreiberhuber A, Meyer C, Marschalek R, Borkhardt A, Pickl WF, Lion T, Gadner H, Haas OA, Dworzak MN, K?nig M, Schneider B. Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity. Clin Cancer Res. 2006 May 15; 12(10):2988-94. PMID: 16707593.
Verschoyle RD, Greaves P, Cai H, Borkhardt A, Broggini M, D'Incalci M, Riccio E, Doppalapudi R, Kapetanovic IM, Steward WP, Gescher AJ. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Cancer Chemother Pharmacol. 2006 Jan; 57(1):1-6. PMID: 16001171.
Wilda M, Perez AV, Bruch J, Woessmann W, Metzler M, Fuchs U, Borkhardt A. Use of MLL/GRAF fusion mRNA for measurement of minimal residual disease during chemotherapy in an infant with acute monoblastic leukemia (AML-M5). Genes Chromosomes Cancer. 2005 Aug; 43(4):424-6. PMID: 15852479.
Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, Friedrich W, Ebell W, Borkhardt A, Bender-Goetze C, F?hrer M. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood. 2005 Sep 15; 106(6):2102-4. PMID: 15933058.
Heidenreich O, Borkhardt A. RNA interference as a potential tool in the treatment of leukaemia. Expert Opin Biol Ther. 2004 Dec; 4(12):1921-9. PMID: 15571454.
Wilda M, Busch K, Klose I, Keller T, Woessmann W, Kreuder J, Harbott J, Borkhardt A. Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus. Genes Chromosomes Cancer. 2004 Oct; 41(2):178-82. PMID: 15287031.
Wilda M, Bruch J, Harder L, Rawer D, Reiter A, Borkhardt A, Woessmann W. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children. Leukemia. 2004 Mar; 18(3):584-8. PMID: 14712292.
Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer. 2004 Feb; 39(2):167-9. PMID: 14695998.
Woessmann W, Zwanzger D, Borkhardt A. ERK signaling pathway is differentially involved in erythroid differentiation of K562 cells depending on time and the inducing agent. Cell Biol Int. 2004; 28(5):403-10. PMID: 15193284.
Callebaut I, Prieur AM, Bodemer C, Lepore L, Derfalvi B, Benjaponpitak S, Vesely R, Sauvain MJ, Oertle S, Allen R, Morgan G, Borkhardt A, Hill C, Gardner-Medwin J, Fischer A, Neven B, Feldmann J, de Saint Basile G. Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood. 2004 Apr 01; 103(7):2809-15. PMID: 14630794.
Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A. The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. FEBS Lett. 2003 Nov 06; 554(1-2):10-6. PMID: 14596906.
Ruf B, Heckmann M, Schroth I, Reiss I, Borkhardt A, Gortner L, H?gens-Penzel M, J?dicke A. Early decompressive craniectomy and duraplasty for refractory intracranial hypertension in children: results of a pilot study. Crit Care. 2003 Dec; 7(6):R133-8. PMID: 14624687; PMCID: PMC374370.
Borkhardt A, Wilda M, Fuchs U, Gortner L, Reiss I. Congenital leukaemia after heavy abuse of permethrin during pregnancy. Arch Dis Child Fetal Neonatal Ed. 2003 Sep; 88(5):F436-7. PMID: 12937054; PMCID: PMC1721623.
Damm-Welk C, Fuchs U, Borkhardt A, W?ssmann W. Targeting oncogenic fusion genes in leukemias and lymphomas by RNA interference. Semin Cancer Biol. 2003 Aug; 13(4):283-92. PMID: 14563123.
Bruch J, Wilda M, Teigler-Schlegel A, Harbott J, Borkhardt A, Metzler M. Occurrence of an MLL/LAF4 fusion gene caused by the insertion ins(11;2)(q23;q11.2q11.2) in an infant with acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2003 May; 37(1):106-9. PMID: 12661012.
Langer T, Metzler M, Reinhardt D, Viehmann S, Borkhardt A, Reichel M, Stanulla M, Schrappe M, Creutzig U, Leis T, Jacobs U, Harbott J, Rascher W, Repp R, Ritter J, Beck JD. Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Genes Chromosomes Cancer. 2003 Apr; 36(4):393-401. PMID: 12619163.
Strehl S, Borkhardt A, Slany R, Fuchs UE, Haas OA, K?nig M. The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). Oncogene. 2003 Jan 09; 22(1):157-60. PMID: 12527918.
Ritter U, Damm-Welk C, Fuchs U, Bohle RM, Borkhardt A, Woessmann W. Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL). Oligonucleotides. 2003; 13(5):365-73. PMID: 15000827.
Wilda M, Fuchs U, Borkhardt A, W?ssmann W. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene. 2002 Aug 22; 21(37):5716-24. PMID: 12173041.
Tuschl T, Borkhardt A. Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Mol Interv. 2002 Jun; 2(3):158-67. PMID: 14993376.
Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O. Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). FEBS Lett. 2002 May 22; 519(1-3):50-8. PMID: 12023017.
Fuchs U, Rehkamp G, Haas OA, Slany R, Konig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8756-61. PMID: 11438682; PMCID: PMC37508.
Ferrari T, Weber B, Pils S, Harbott J, Borkhardt A. Absence of point mutations within the AML-1 gene in patients with MDS/AML and loss of chromosome 5q or 7. Ann Hematol. 2001 Feb; 80(2):72-3. PMID: 11261327.
Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9168-73. PMID: 10908648; PMCID: PMC16840.
Weber B, Borkhardt A, Stoll-Becker S, Reiss I, Gortner L. Polymorphisms of surfactant protein A genes and the risk of bronchopulmonary dysplasia in preterm infants. Turk J Pediatr. 2000 Jul-Sep; 42(3):181-5. PMID: 11105614.
Viehmann S, Borkhardt A, Lampert F, Harbott J. Multiplex PCR--a rapid screening method for detection of gene rearrangements in childhood acute lymphoblastic leukemia. Ann Hematol. 1999 Apr; 78(4):157-62. PMID: 10348146.
Borkhardt A, Harbott J, Lampert F. Biology and clinical significance of the TEL/AML1 rearrangement. Curr Opin Pediatr. 1999 Feb; 11(1):33-8. PMID: 10084082.
Leis T, Repp R, Borkhardt A, Metzler M, Harbott J, Lampert F, Schl?ger F. A new fingerprint method for sequence analysis of chromosomal translocations at the genomic DNA level. Leukemia. 1998 May; 12(5):758-63. PMID: 9593275.
Harbott J, Viehmann S, Borkhardt A, Henze G, Lampert F. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse. Blood. 1997 Dec 15; 90(12):4933-7. PMID: 9389711.
Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L, Mangioni S, Schrappe M, Riehm H, Lampert F, Basso G, Masera G, Harbott J, Biondi A. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-M?nster Study Group. Blood. 1997 Jul 15; 90(2):571-7. PMID: 9226156.
Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). Oncogene. 1997 Jan 16; 14(2):195-202. PMID: 9010221.
Schlieben S, Borkhardt A, Reinisch I, Ritterbach J, Janssen JW, Ratei R, Schrappe M, Repp R, Zimmermann M, Kabisch H, Janka-Schaub G, Bartram CR, Ludwig WD, Riehm H, Lampert F, Harbott J. Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92. Leukemia. 1996 Jun; 10(6):957-63. PMID: 8667652.
Kreuder J, Borkhardt A, Repp R, Pekrun A, Gottschalk U, Reichmann H, Schachenmayr W, Schlegel K, Lampert F, G?ttsche B. Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase A. N Engl J Med. 1996 Apr 25; 334(17):1100-4. PMID: 8598869.
Borkhardt A, Brettreich S, Borkhardt AK, Repp R, Harbott J, Kreuder J, Lampert F. Low frequency of RAS gene mutations and absence of mutations within the FLR exon of NF1 in patients with therapy-related leukemias. Leukemia. 1995 Oct; 9(10):1790-1. PMID: 7564528.
Borkhardt A, Grathwohl J, Repp R, Rheinisch-Becker I, Bohle RM, Lampert F, Bl?tters-Sawatzki R. Secondary acute myeloid leukemia with translocation (4;11) and MLL/AF4 rearrangement in a 15-year-old boy treated for common acute lymphoblastic leukemia 11 years earlier. Ann Hematol. 1995 Jan; 70(1):31-5. PMID: 7827204.
Repp R, Borkhardt A, Haupt E, Kreuder J, Brettreich S, Hammermann J, Nishida K, Harbott J, Lampert F. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia. 1995 Jan; 9(1):210-5. PMID: 7845020.
Borkhardt A, Repp R, Haupt E, Brettreich S, Buchen U, Gossen R, Lampert F. Molecular analysis of MLL-1/AF4 recombination in infant acute lymphoblastic leukemia. Leukemia. 1994 Apr; 8(4):549-53. PMID: 8152249.
Heidemann A, Borkhardt A, Velcovsky HG, Altmannsberger HM, Bohle RM. [Detection of mycobacterial DNA from paraffin-embedded tissue in lung and lymphoid epithelial granulomas]. Verh Dtsch Ges Pathol. 1994; 78:189-94. PMID: 7533984.
Borkhardt A, Repp R, Harbott J, Lakomek M, Janssen JW, Schlieben S, Bartram CR, Lampert F. BCR-ABL rearrangement in a child with acute myelogenous leukaemia without a Philadelphia chromosome. Br J Haematol. 1993 Jun; 84(2):341-2. PMID: 8398840.
Borkhardt A, Repp R, Harbott J, Kreuder J, Lampert F. Quantification of leukaemic cells based on heteroduplex formation of tal-1 gene sequences after PCR coamplification. Br J Haematol. 1993 Jan; 83(1):39-44. PMID: 8435335.
Repp R, Csecke A, Kreuder J, Borkhardt A, Willems WR, Lampert F, Gerlich WH, von H?rsten B. Clinical and immunological aspects of hepatitis B virus infection in children receiving multidrug cancer chemotherapy. Arch Virol Suppl. 1993; 8:103-11. PMID: 8260857.
Borkhardt A, Repp R, Harbott J, Keller C, Berner F, Ritterbach J, Lampert F. Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia. Ann Hematol. 1992 Jun; 64(6):305-8. PMID: 1637887.
Repp R, Keller C, Borkhardt A, Csecke A, Schaefer S, Gerlich WH, Lampert F. Detection of a hepatitis B virus variant with a truncated X gene and enhancer II. Arch Virol. 1992; 125(1-4):299-304. PMID: 1642555.
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year
Publications
1994
2
1995
5
1996
3
1997
3
1998
1
1999
3
2000
2
2001
2
2002
4
2003
10
2004
10
2005
3
2006
5
2007
4
2008
7
2009
5
2010
9
2011
10
2012
17
2013
16
2014
21
2015
21
2016
18
2017
26
2018
33
2019
17
2020
14
2021
24
2022
30
2023
19
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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