"Centrosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).
Descriptor ID |
D018385
|
MeSH Number(s) |
A11.284.430.214.190.750.585.160 A11.284.430.214.190.750.820.500.500
|
Concept/Terms |
Pericentriolar Region- Pericentriolar Region
- Pericentriolar Regions
- Region, Pericentriolar
- Regions, Pericentriolar
|
Below are MeSH descriptors whose meaning is more general than "Centrosome".
Below are MeSH descriptors whose meaning is more specific than "Centrosome".
This graph shows the total number of publications written about "Centrosome" by people in this website by year, and whether "Centrosome" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2010 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2014 | 1 | 0 | 1 |
2015 | 1 | 1 | 2 |
2016 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Centrosome" by people in Profiles.
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Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells. J Cell Biol. 2022 12 05; 221(12).
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A Homozygous AKNA Frameshift Variant Is Associated with Microcephaly in a Pakistani Family. Genes (Basel). 2021 09 24; 12(10).
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CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Mol Genet Genomics. 2017 Apr; 292(2):365-383.
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The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS Genet. 2015 Dec; 11(12):e1005749.
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TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). Elife. 2015 Sep 19; 4.
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Coiled-coil proteins facilitated the functional expansion of the centrosome. PLoS Comput Biol. 2014 Jun; 10(6):e1003657.
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CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. Hum Mol Genet. 2013 Dec 20; 22(25):5199-214.
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A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function. Am J Hum Genet. 2012 May 04; 90(5):871-8.
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A flexible multiwell format for immunofluorescence screening microscopy of small-molecule inhibitors. Assay Drug Dev Technol. 2010 Oct; 8(5):571-80.