"Ophthalmoplegia, Chronic Progressive External" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
Descriptor ID |
D017246
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MeSH Number(s) |
C05.651.460.700 C10.292.562.750.250 C10.597.622.447.511 C10.668.491.500.700 C11.590.472.250 C18.452.660.560.700 C23.888.592.636.447.511
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Concept/Terms |
Ophthalmoplegia, Chronic Progressive External- Ophthalmoplegia, Chronic Progressive External
- Graefe Disease
- Disease, Graefe
- Mitochondrial Ocular Myopathy
- Myopathy, Mitochondrial Ocular
- Ocular Myopathy, Mitochondrial
- Chronic Progressive External Ophthalmoplegia
- Graefe's Disease
- Ocular Myopathy of Von Graefe-Fuchs
- Ocular Myopathy of Von Graefe Fuchs
- Ophthalmoplegia, Progressive External
- External Ophthalmoplegia, Progressive
- Progressive External Ophthalmoplegia
- CPEO
- Ocular Muscular Dystrophy
- Dystrophy, Ocular Muscular
- Muscular Dystrophies, Ocular
- Muscular Dystrophy, Ocular
- Ocular Muscular Dystrophies
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Below are MeSH descriptors whose meaning is more general than "Ophthalmoplegia, Chronic Progressive External".
Below are MeSH descriptors whose meaning is more specific than "Ophthalmoplegia, Chronic Progressive External".
This graph shows the total number of publications written about "Ophthalmoplegia, Chronic Progressive External" by people in this website by year, and whether "Ophthalmoplegia, Chronic Progressive External" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 2 | 0 | 2 |
1997 | 1 | 0 | 1 |
2000 | 1 | 2 | 3 |
2004 | 3 | 0 | 3 |
2005 | 1 | 0 | 1 |
2008 | 2 | 1 | 3 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ophthalmoplegia, Chronic Progressive External" by people in Profiles.
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Distinct segregation of the pathogenic m.5667G>A mitochondrial tRNAAsn mutation in extraocular and skeletal muscle in chronic progressive external ophthalmoplegia. Neuromuscul Disord. 2019 05; 29(5):358-367.
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Apraxia of lid opening mimicking ptosis in compound heterozygosity for A467T and W748S POLG1 mutations. Mov Disord. 2008 Jul 15; 23(9):1286-8.
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[Chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome : interdisciplinary diagnosis and therapy]. Ophthalmologe. 2008 Jun; 105(6):550-6.
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Concerted action of two novel tRNA mtDNA point mutations in chronic progressive external ophthalmoplegia. Biosci Rep. 2008 Apr; 28(2):89-96.
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Dopamine transporter SPECT in patients with mitochondrial disorders. J Neurol Neurosurg Psychiatry. 2005 Jan; 76(1):118-20.
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[Diagnostic value of mitochondrial DNA analysis in chronic progressive external ophthalmoplegia (CPEO)]. Klin Monbl Augenheilkd. 2004 Dec; 221(12):1057-61.
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Tissue dependent co-segregation of the novel pathogenic G12276A mitochondrial tRNALeu(CUN) mutation with the A185G D-loop polymorphism. J Med Genet. 2004 Dec; 41(12):e124.
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Diagnostic value of mitochondrial DNA mutation analysis in juvenile unilateral ptosis. Graefes Arch Clin Exp Ophthalmol. 2005 Apr; 243(4):380-2.
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Flux control of cytochrome c oxidase in human skeletal muscle. J Biol Chem. 2000 Sep 08; 275(36):27741-5.
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New insights into the metabolic consequences of large-scale mtDNA deletions: a quantitative analysis of biochemical, morphological, and genetic findings in human skeletal muscle. J Neuropathol Exp Neurol. 2000 May; 59(5):353-60.