"Uncoupling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
| Descriptor ID |
D014475
|
| MeSH Number(s) |
D27.505.519.389.936
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Agents".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Agents".
This graph shows the total number of publications written about "Uncoupling Agents" by people in this website by year, and whether "Uncoupling Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Uncoupling Agents" by people in Profiles.
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Complex III-dependent superoxide production of brain mitochondria contributes to seizure-related ROS formation. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):1163-70.
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Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats. Brain Res. 1999 May 01; 826(2):236-42.
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Use of NAD(P)H and flavoprotein fluorescence signals to characterize the redox state of pyridine nucleotides in epididymal bull spermatozoa. Biochim Biophys Acta. 1991 Feb 08; 1056(3):273-8.
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Long-chain fatty acids act as protonophoric uncouplers of oxidative phosphorylation in rat liver mitochondria. Biochim Biophys Acta. 1989 Dec 07; 977(3):266-72.
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[ATP-metabolizing enzymes in suspensions of isolated coupled rat brain mitochondria]. Biomed Biochim Acta. 1987; 46(5):331-40.
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Control of mitochondrial respiration. FEBS Lett. 1983 Jan 10; 151(1):1-9.
MeSH information
