"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Descriptor ID |
D007515
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MeSH Number(s) |
A03.734.414 A06.407.414
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Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
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Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2013 | 0 | 1 | 1 |
2015 | 0 | 2 | 2 |
2017 | 1 | 1 | 2 |
2018 | 1 | 0 | 1 |
2021 | 3 | 0 | 3 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nat Metab. 2021 07; 3(7):1017-1031.
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The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells. Diabetologia. 2021 06; 64(6):1358-1374.
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SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab. 2021 02; 3(2):149-165.
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Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet. 2018 11; 50(11):1505-1513.
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Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nat Commun. 2017 06 06; 8:15652.
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CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage. Sci Rep. 2017 03 16; 7:44661.
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet. 2015 Dec; 47(12):1415-25.
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Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia. 2016 Jan; 59(1):139-150.
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The systemic immune network in recent onset type 1 diabetes: central role of interleukin-1 receptor antagonist (DIATOR Trial). PLoS One. 2013; 8(8):e72440.
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Catabolism of proinsulin and insulin. Proteolytic activities in Langerhans islets of rat and mice pancreas in vitro. Acta Biol Med Ger. 1974; 33(4):407-18.