"DNA Polymerase gamma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.
| Descriptor ID |
D000074002
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.169 D12.776.575.280
|
| Concept/Terms |
DNA Polymerase gamma- DNA Polymerase gamma
- Polymerase gamma, DNA
- Mitochondrial DNA Polymerase
- DNA Polymerase, Mitochondrial
- Polymerase, Mitochondrial DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase gamma".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase gamma".
This graph shows the total number of publications written about "DNA Polymerase gamma" by people in this website by year, and whether "DNA Polymerase gamma" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 3 | 3 |
| 2010 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase gamma" by people in Profiles.
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Linear mitochondrial DNA is rapidly degraded by components of the replication machinery. Nat Commun. 2018 04 30; 9(1):1727.
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Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease. Hum Mol Genet. 2014 Dec 01; 23(23):6147-62.
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POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts. Biochim Biophys Acta. 2011 Mar; 1812(3):321-5.
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Mitochondrial dysfunction in neurological disorders with epileptic phenotypes. J Bioenerg Biomembr. 2010 Dec; 42(6):443-8.
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Proof of progression over time: finally fulminant brain, muscle, and liver affection in Alpers syndrome associated with the A467T POLG1 mutation. Seizure. 2009 Apr; 18(3):232-4.
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Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma. J Neuropathol Exp Neurol. 2008 Sep; 67(9):857-66.
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Apraxia of lid opening mimicking ptosis in compound heterozygosity for A467T and W748S POLG1 mutations. Mov Disord. 2008 Jul 15; 23(9):1286-8.
MeSH information
