"Histone Deacetylase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.
Descriptor ID |
D000073864
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MeSH Number(s) |
D08.811.277.087.520.350
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histone Deacetylase 6".
Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylase 6".
This graph shows the total number of publications written about "Histone Deacetylase 6" by people in this website by year, and whether "Histone Deacetylase 6" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2018 | 0 | 1 | 1 |
2020 | 1 | 0 | 1 |
2021 | 0 | 1 | 1 |
2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Histone Deacetylase 6" by people in Profiles.
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Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J Med Chem. 2022 Nov 24; 65(22):15457-15472.
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Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity. ChemMedChem. 2021 06 07; 16(11):1798-1803.
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Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 2020 09 24; 63(18):10339-10351.
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Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 11 21; 61(22):10299-10309.