"Tangier Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.
| Descriptor ID |
D013631
|
| MeSH Number(s) |
C10.668.829.800.875 C16.320.565.398.500.330.750 C18.452.584.500.875.330.750 C18.452.648.398.500.330.750
|
| Concept/Terms |
Tangier Disease- Tangier Disease
- High Density Lipoprotein Deficiency, Type 1
- High-Density Lipoprotein Deficiency, Tangier Type
- High Density Lipoprotein Deficiency, Tangier Type
- Alpha High Density Lipoprotein Deficiency Disease
- Analphalipoproteinemia
- Analphalipoproteinemias
- Cholesterol Thesaurismosis
- Cholesterol Thesaurismoses
- Thesaurismoses, Cholesterol
- Thesaurismosis, Cholesterol
- HDLDT1
- High-Density Lipoprotein Deficiency, Type I
- High Density Lipoprotein Deficiency, Type I
Tangier Disease Neuropathy- Tangier Disease Neuropathy
- Neuropathy of Tangier Disease
- Tangier Hereditary Neuropathy
- A-alphalipoprotein Neuropathy
- A-alphalipoprotein Neuropathies
- Neuropathies, A-alphalipoprotein
- Neuropathy, A-alphalipoprotein
|
Below are MeSH descriptors whose meaning is more general than "Tangier Disease".
Below are MeSH descriptors whose meaning is more specific than "Tangier Disease".
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MeSH information
