"Integrin alpha Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
| Descriptor ID |
D039001
|
| MeSH Number(s) |
D12.776.543.750.705.408.100
|
| Concept/Terms |
Integrin alpha Chains- Integrin alpha Chains
- alpha Chains, Integrin
- Integrin alpha Subunits
- alpha Integrins
- Integrins, alpha
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha Chains".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha Chains".
This graph shows the total number of publications written about "Integrin alpha Chains" by people in this website by year, and whether "Integrin alpha Chains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha Chains" by people in Profiles.
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Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat Immunol. 2015 Jul; 16(7):718-28.
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Organization of the mouse and human DC network. Curr Opin Immunol. 2014 Feb; 26:90-9.
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Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog. 2013 Jan; 9(1):e1003115.
MeSH information
