"Calreticulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
| Descriptor ID |
D037282
|
| MeSH Number(s) |
D12.644.360.372.374 D12.776.157.125.412.374 D12.776.476.387.374 D12.776.503.303
|
| Concept/Terms |
Calreticulin- Calreticulin
- CAB-63
- CBP3 (Liver)
- ERp60
- cC1qR Protein
- Calcium-Binding Protein-3
- Calcium Binding Protein 3
- Calregulin
- 55-kDa High-Affinity Calcium Binding Protein
- 55 kDa High Affinity Calcium Binding Protein
- HACBP
|
Below are MeSH descriptors whose meaning is more general than "Calreticulin".
Below are MeSH descriptors whose meaning is more specific than "Calreticulin".
This graph shows the total number of publications written about "Calreticulin" by people in this website by year, and whether "Calreticulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calreticulin" by people in Profiles.
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CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes. Stem Cell Reports. 2021 11 09; 16(11):2768-2783.
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JAK2V617F but not CALR mutations confer increased molecular responses to interferon-a via JAK1/STAT1 activation. Leukemia. 2019 04; 33(4):995-1010.
MeSH information
