"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
| Descriptor ID |
D016335
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.985
|
| Concept/Terms |
Zinc Fingers- Zinc Fingers
- Finger, Zinc
- Fingers, Zinc
- Zinc Finger
- Zinc Finger Motifs
- Motif, Zinc Finger
- Motifs, Zinc Finger
- Zinc Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "Zinc Fingers".
Below are MeSH descriptors whose meaning is more specific than "Zinc Fingers".
This graph shows the total number of publications written about "Zinc Fingers" by people in this website by year, and whether "Zinc Fingers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Fingers" by people in Profiles.
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Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. J Am Soc Nephrol. 2021 03; 32(3):580-596.
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Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo. Cell Prolif. 2020 Oct; 53(10):e12892.
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A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking. Elife. 2015 May 18; 4.
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Variant 1859G-->A (Arg620Gln) of the "hairless" gene: absence of association with papular atrichia or androgenic alopecia. Am J Hum Genet. 2001 Jul; 69(1):235-7.
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Silencing of developmental genes in Hydra. Dev Biol. 1999 Oct 01; 214(1):211-4.
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Head-specific gene expression in Hydra: complexity of DNA- protein interactions at the promoter of ks1 is inversely correlated to the head activation potential. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1445-50.
MeSH information
